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Protein
Submitted name:

PKHD1

Gene

Pkhd1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
PKHD1Imported
Gene namesi
Name:Pkhd1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2155808. Pkhd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3853 – 387624HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 40604042Sequence analysisPRO_5004280003Add
BLAST

Proteomic databases

PaxDbiQ6T3A5.
PRIDEiQ6T3A5.

PTM databases

iPTMnetiQ6T3A5.
PhosphoSiteiQ6T3A5.

Expressioni

Gene expression databases

GenevisibleiQ6T3A5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085794.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1928 – 2049122G8InterPro annotationAdd
BLAST
Domaini2742 – 2868127G8InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEIF. Eukaryota.
ENOG410XQ01. LUCA.
HOGENOMiHOG000115555.
HOVERGENiHBG053604.
KOiK19865.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
2.60.40.10. 6 hits.
InterProiIPR019316. G8_domain.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR028839. PKHD1.
[Graphical view]
PANTHERiPTHR11915:SF299. PTHR11915:SF299. 1 hit.
PfamiPF10162. G8. 2 hits.
PF01833. TIG. 6 hits.
[Graphical view]
SMARTiSM01225. G8. 2 hits.
SM00429. IPT. 6 hits.
SM00710. PbH1. 7 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 3 hits.
SSF81296. SSF81296. 6 hits.
PROSITEiPS51484. G8. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6T3A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLAWLVSLL SMEVLLLAKP YSSFQIEPAE GSLAGGTWIT VVFDGLDRSI
60 70 80 90 100
LYPNNGSQLQ IDLVSVAIPT LRIPCDVSPA FVDLPVVTCQ TRSLPSEADA
110 120 130 140 150
GPYSLEMRSG EQVLGTPCPG SLDSCTFKFS KDQTPVLYQV YPASGVPGEV
160 170 180 190 200
VSVYGRVITT WLETFDPDVD YIESPLILEA REDKWLTPCS LINRQTGSCF
210 220 230 240 250
PIQEEHGLGN VQCRVEGDYI GSQNVSFSVF NKGRSMVHKE AWLISAKQEL
260 270 280 290 300
FLYQTYPEIL SVFPKVGSLG GRTDIIITGD FFDPSARVTI AGIPCDIRYV
310 320 330 340 350
SPRKIECTTR APGNEARLTA PQAGNRGLRF EVGDATKDVE LTEATPGYRW
360 370 380 390 400
QIVPNASSPS GFWSKEGRPF RARLSGFFVA PQTNNYTFWI QADSQASLCF
410 420 430 440 450
SSSEEPRTKV EVASVGVGTA DWFDSWEQIG NEGSWHQKTT KLELQGGAKY
460 470 480 490 500
YLEAEQHGIA PSRGMRIGVQ IHNTWLNPDV VNTYLLEKHQ IRARAQRLPE
510 520 530 540 550
IQVLHVSGKG NFFLTWGNVS SQPVPANATA QQIQTTIEEL LVVKCNLAPF
560 570 580 590 600
SARVLLRLGF EQGLEGSRSD GVLTSSTEPF CGRFGLGQLG HLILIPEAAD
610 620 630 640 650
KGYQPDRYPY LCLAYRGHMN KTLDMTVSFL FGFQNIMKNI TCDWSLTNPH
660 670 680 690 700
PESWQFTCIN LWDTCLCHSE DLQSSLANTP LLVHRIDIRP VVPEAGLLYV
710 720 730 740 750
DEIILADTNV TVSQADSGRA CPGGNVVESV SVVGVPPVYS ISSWLAGCGS
760 770 780 790 800
ELPLITACSV STEGTGDGSE LIEVTAQRLQ RTSPPLGGHF FLYLSDTVIT
810 820 830 840 850
DVPVRMSARQ LHKLLQDSAD ESTSGYLNAG DFTVTEDLNS CYEHVWTLSW
860 870 880 890 900
TTQTGDLPNF IRVSDQNLTG VNPTVTARVV YDGGVFLGPL FGDMLATANQ
910 920 930 940 950
QTQVAVQVND IPAYCSGSCS FQYQQESTPS VDHVWYSLGS DVNLLVHFTG
960 970 980 990 1000
TGFPRDTQFL QVPVNKTSCE VLFSNETNVA CELALLPVGV HQIFMLVIPS
1010 1020 1030 1040 1050
GLAVNASGED LLLHVEPRLD AVEPSTAAEI GGRWVTLRGS SLEGVSLVLF
1060 1070 1080 1090 1100
GTQSCVIDAI RSNSQQIQCK VPPRGKVGYT VNVTVISGDH STVLARAFTY
1110 1120 1130 1140 1150
VSSLNPVIVS LSRNRSSIAG GEILFLGMSL LVNYTDLDVQ IHVQDTSAQV
1160 1170 1180 1190 1200
LSQTAWGLEV VLPPLVPGIH AISAFINGVS IRSQGVDLYI QYLTEVFSVE
1210 1220 1230 1240 1250
PCSGSLLGGT LLNLLGTGLG RDPALIRVLV DNHPCDIVDL TEVNIWCETP
1260 1270 1280 1290 1300
PAVLPPRADV LTVPASVEIW AGNTSFFHGP SLVGKGFTFT YEAAATPVVT
1310 1320 1330 1340 1350
AMWGEFRNNS VRFYVEGSNI SDSVILLGSL KCELEVQFFG DSMNLFGCFF
1360 1370 1380 1390 1400
PLHSLEAGVY TLQVRHKRMG FANMSVVPQK FELSPQIIAI FPTHGSKCGG
1410 1420 1430 1440 1450
TVLTVKGMAF SSRKRSVHVD ISGPFACMIL SLEDHTVLCQ TRFVGDQFSE
1460 1470 1480 1490 1500
ASLALNITVL VNGLTSKCKG NCTLFIEEAA TPNVDALTIS ISGSLTMVLM
1510 1520 1530 1540 1550
RGRRLATTAD EPIAFVHDQL PCHTTFFNTS HVACQIRDLA PGFHYLSAVH
1560 1570 1580 1590 1600
TSAGYACLNS VSRNFFIVPQ VLDYFPKDFS IHGGSLLTIK GTALRGWKAT
1610 1620 1630 1640 1650
VVYVGRQACL TVNFSSDFIQ CIVPAGNGSA ALEIDVDGVL YHIGLVDYSS
1660 1670 1680 1690 1700
IFTPELLSVS RSQDILTFTV ARISGAANVD IFIGTSPCLG VAGNRTVLQC
1710 1720 1730 1740 1750
MVPLLPAGEY LVTGYDHSRG WASSTLILVL RATVTSVTKN YGCLGGRLLH
1760 1770 1780 1790 1800
VLGAGFSPGN ISAAVCGAPC QVLANATVSA FSCLVLPLDV SLAFLCDLRH
1810 1820 1830 1840 1850
AEDSCKVRSS TYLQCDLTVS MGTERLPGSW PYVYLCEESS LCLFEPDHWT
1860 1870 1880 1890 1900
ESVFPSFSGL FLSPKVERDE VLIYNSSCNI TMETEAEMEC EMPNQPITAK
1910 1920 1930 1940 1950
ITEIQKNWGQ NTQGNFSFQF CRRWSRPHSW FPQRVPHDGD SVTVETGHLL
1960 1970 1980 1990 2000
LLDANTSFLN SLHIKGGKLI FMDPGPIELR AHSILITDGG ELHIGSEEKP
2010 2020 2030 2040 2050
FQGKARIKIY GSVHSTPFFP YGVKFLAVRN GTLSLHGSVP EVTVTYLQAA
2060 2070 2080 2090 2100
AHAGDKVLTL GEAVDWKPGD EAVITSGMTV AGAEATEVVV VETVHNADLH
2110 2120 2130 2140 2150
LRNPLRYSYD FRENWVAGEN PILKPSVALL SRNIIIQGNF TLERVKLLNS
2160 2170 2180 2190 2200
CQEANTAKGN LKHCLYSKSE KMLGARDLGA RVIIQSFPEE PSFVKLKGVQ
2210 2220 2230 2240 2250
FRDLGQAFHK HLSSLALVGA MRGSYIQSCS VWNSFSRGLS MHRTWGLKVD
2260 2270 2280 2290 2300
SNVFYKIVGH ALLLGLPTWT EGLALVRLLL EEKNGWWEQG STIRNNVIIS
2310 2320 2330 2340 2350
VSAAEGLSGS EMLAPAGIYT FSPTNVMEGN RVCAAGYGYV FHLVTSQTLQ
2360 2370 2380 2390 2400
APLLSFNWNT AHSCTRYGLL VYPKFQPPWN NDTGFTLFQN FMVWGSAGGA
2410 2420 2430 2440 2450
QIFRSNNLHL KNFQVYACRD FGIDILESDE NTLITDSFLL GHFTHKGSLC
2460 2470 2480 2490 2500
MSAGIKTPQR WELTISNTTF VNFDDNCVAI RTCSGCFQGQ GGYTVKTRQL
2510 2520 2530 2540 2550
KFVNSSNLVA FPFPHAAVLE DLDGSLSGKN GSHVLASMET LSDTCLTNAS
2560 2570 2580 2590 2600
FSQIVPGSVC GEAVLFHRMS IALANSLDVP KNLTITDIGN KTITVNYVED
2610 2620 2630 2640 2650
TLSNYYGWMA LLLDQETYSL QFESPWMNRS LQYSATFDSF APGNYLLIMH
2660 2670 2680 2690 2700
RDLPPYPDIL LRCGSQVGHS LPFHPLPSQD RACDWFFNRQ LRQLTYLVSG
2710 2720 2730 2740 2750
EGQVKVFLQL KPGVPPSVSA STSVPESASR WSLPETWQDV EKGWGGYNHT
2760 2770 2780 2790 2800
IPGPGDDVLI LPNKTVLVDT DLPVLRCLYV MGTLEFPVDR SNVLSVACLL
2810 2820 2830 2840 2850
IAGGELKVGT LENPLEKDQR LLIFLRASEE VVCDYFEGIH VDPGTIGVYG
2860 2870 2880 2890 2900
KLRLHSAYPK KSWVHLGADI APGNERIIVH NAVDWQPHDT IVLSSSSYEA
2910 2920 2930 2940 2950
HEAEVLTVKE VKGHHIRIYE RLKHRHIGST HIMEDGQQIH LAAEVGLLTR
2960 2970 2980 2990 3000
NIRIQPDSSC RGRLLVGSFR KSSGEDFSGV LQLLNVEIQN MGLPLYSSIE
3010 3020 3030 3040 3050
FTGVSAGSWV ISSTVHQSCS VGIHASSSHG VILTDNVVFG TNGHGIDVEG
3060 3070 3080 3090 3100
QNYSLTNNLV ILTMQSANSS PWVAGIKVNY AEDIILHGNV VAGSERLGFH
3110 3120 3130 3140 3150
VGGHGCSSEV LWSDNVVHSS LHGLHLYKKH ESNNCTGVSG FMAFKNFDYG
3160 3170 3180 3190 3200
AMVQTENSVD IQNITLVDNT VGLLAITYVS SALLSSVSTV QITLRNSVIV
3210 3220 3230 3240 3250
ATSSSFDCIH DRKAPQSANW TSTDRAPSNP RGGRIGILWP VSASEPNAWP
3260 3270 3280 3290 3300
QEPWHKVRSH HSVPGIMKLQ DVTFSSFVKS CYSNDLDVCI LPNEYSTGVM
3310 3320 3330 3340 3350
YPITAERTRM LGIKDKNKFY FPVLQSSKDL VGTICPTLVC EYPRKYLFTD
3360 3370 3380 3390 3400
LDGRTLGLPP PVSVFPRTEE EWTGSFLNTG IFREEQKCTF RAMNQGFFCK
3410 3420 3430 3440 3450
QTEHAVLILD NVDATWTIPK SHPLVSVTNG FVDTFSIVKD SDLCPPTSSL
3460 3470 3480 3490 3500
STFYSILPTR QMTKVCFPEQ TPPFLRFLLL GNQRASKLIL AVFYNEIQSP
3510 3520 3530 3540 3550
HVFLDKSFIP PTSLESAFSL LAXPSGANYF DIMNNLLYVV LQGEEPVEIH
3560 3570 3580 3590 3600
SSVSIHLALT VTFSVLEKGW ERAMLESLSD FFQIDPNQIR LTLEMPGNKE
3610 3620 3630 3640 3650
TLEAIANSER KRKRNCPSVT CGGPSIRYGQ RRPLMAEMTS LKITPATTLE
3660 3670 3680 3690 3700
TFSKVIVIEV GDLPNIRNSE PIQSLPSNRL QRLVNQVITA QQTGALENVL
3710 3720 3730 3740 3750
GMTVGALLVT QSKGVTGYRN ASSLITGNLI YTRPSELSIL VQPSDGEVGI
3760 3770 3780 3790 3800
ELPVQPRLVF LDEKNERVES LGLPSEPWII SVSLEGASES VLKGCTLAET
3810 3820 3830 3840 3850
RDGYVTFSRL AVLISGSNWH LFFTVISPPG TNFTARSRTF VVLPVASKER
3860 3870 3880 3890 3900
STIILALSLC SVASWVALSC LVCCWFKKSK TRKIKPEDIS ESQAKEQKKN
3910 3920 3930 3940 3950
THNSSKPRGL QAKTAKENTL MGEDMRMKVM QGMQSQFPQH SMDGVSKRKV
3960 3970 3980 3990 4000
SRLAVTEERT TTPAPKIPRI TCVPGSLAQQ LTLQEPGNWQ EAQQQLLRYQ
4010 4020 4030 4040 4050
LAGRNQLLLL RPDLRQERKQ GQEPSQLDKG SDCTGLSQEK ATCIPTETFS
4060
LHTAPPETIQ
Length:4,060
Mass (Da):445,053
Last modified:July 5, 2004 - v1
Checksum:i224324699319A6D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY438374 mRNA. Translation: AAS00499.1.
RefSeqiNP_694819.2. NM_153179.3.
UniGeneiMm.249253.

Genome annotation databases

GeneIDi241035.
KEGGimmu:241035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY438374 mRNA. Translation: AAS00499.1.
RefSeqiNP_694819.2. NM_153179.3.
UniGeneiMm.249253.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085794.

PTM databases

iPTMnetiQ6T3A5.
PhosphoSiteiQ6T3A5.

Proteomic databases

PaxDbiQ6T3A5.
PRIDEiQ6T3A5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi241035.
KEGGimmu:241035.

Organism-specific databases

CTDi5314.
MGIiMGI:2155808. Pkhd1.

Phylogenomic databases

eggNOGiENOG410IEIF. Eukaryota.
ENOG410XQ01. LUCA.
HOGENOMiHOG000115555.
HOVERGENiHBG053604.
KOiK19865.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevisibleiQ6T3A5. MM.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
2.60.40.10. 6 hits.
InterProiIPR019316. G8_domain.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR028839. PKHD1.
[Graphical view]
PANTHERiPTHR11915:SF299. PTHR11915:SF299. 1 hit.
PfamiPF10162. G8. 2 hits.
PF01833. TIG. 6 hits.
[Graphical view]
SMARTiSM01225. G8. 2 hits.
SM00429. IPT. 6 hits.
SM00710. PbH1. 7 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 3 hits.
SSF81296. SSF81296. 6 hits.
PROSITEiPS51484. G8. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6T3A5_MOUSE
AccessioniPrimary (citable) accession number: Q6T3A5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.