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Protein

ADP-ribosylation factor-like protein 9

Gene

ARL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 32GTPBy similarity8
Nucleotide bindingi69 – 73GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.2 2681

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 9
Gene namesi
Name:ARL9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000196503.2
HGNCiHGNC:23592 ARL9
MIMi612405 gene
neXtProtiNX_Q6T311

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196503
PharmGKBiPA134987258

Polymorphism and mutation databases

BioMutaiARL9
DMDMi74749334

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002074751 – 187ADP-ribosylation factor-like protein 9Add BLAST187

Proteomic databases

MaxQBiQ6T311
PaxDbiQ6T311
PeptideAtlasiQ6T311
PRIDEiQ6T311
TopDownProteomicsiQ6T311-1 [Q6T311-1]

PTM databases

iPTMnetiQ6T311
PhosphoSitePlusiQ6T311

Expressioni

Gene expression databases

BgeeiENSG00000196503
CleanExiHS_ARL9
ExpressionAtlasiQ6T311 baseline and differential
GenevisibleiQ6T311 HS

Organism-specific databases

HPAiHPA072942

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353210

Structurei

3D structure databases

ProteinModelPortaliQ6T311
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00910000144193
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiQ6T311
KOiK07957
OMAiAYCITDI
OrthoDBiEOG091G0RFE
PhylomeDBiQ6T311
TreeFamiTF105469

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6T311-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPTWKALSH PAWPEEKNKQ ILVLGLDGAG KTSVLHSLAS NRVQHSVAPT
60 70 80 90 100
QGFHAVCINT EDSQMEFLEI GGSKPFRSYW EMYLSKGLLL IFVVDSADHS
110 120 130 140 150
RLPEAKKYLH QLIAANPVLP LVVFANKQDL EAAYHITDIH EALALSEVGN
160 170 180
DRKMFLFGTY LTKNGSEIPS TMQDAKDLIA QLAADVQ
Length:187
Mass (Da):20,755
Last modified:July 5, 2004 - v1
Checksum:i620432EC357013EA
GO
Isoform 2 (identifier: Q6T311-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):13,784
Checksum:i2D93520881AD20A5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0554131 – 64Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY439003 mRNA Translation: AAS07576.1
AC114766 Genomic DNA No translation available.
AC108215 Genomic DNA No translation available.
BM854066 mRNA No translation available.
CCDSiCCDS59474.1 [Q6T311-2]
RefSeqiNP_996802.1, NM_206919.1 [Q6T311-2]
XP_005265777.1, XM_005265720.3 [Q6T311-2]
XP_006714099.1, XM_006714036.3 [Q6T311-2]
UniGeneiHs.444449

Genome annotation databases

EnsembliENST00000360096; ENSP00000353210; ENSG00000196503 [Q6T311-2]
GeneIDi132946
KEGGihsa:132946
UCSCiuc003hby.2 human [Q6T311-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARL9_HUMAN
AccessioniPrimary (citable) accession number: Q6T311
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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