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Protein

ADP-ribosylation factor-like protein 9

Gene

ARL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 32GTPBy similarity8
Nucleotide bindingi69 – 73GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.2. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 9
Gene namesi
Name:ARL9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:23592. ARL9.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196503.
PharmGKBiPA134987258.

Polymorphism and mutation databases

BioMutaiARL9.
DMDMi74749334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002074751 – 187ADP-ribosylation factor-like protein 9Add BLAST187

Proteomic databases

EPDiQ6T311.
MaxQBiQ6T311.
PaxDbiQ6T311.
PRIDEiQ6T311.
TopDownProteomicsiQ6T311-1. [Q6T311-1]

PTM databases

iPTMnetiQ6T311.
PhosphoSitePlusiQ6T311.

Expressioni

Gene expression databases

BgeeiENSG00000196503.
CleanExiHS_ARL9.
GenevisibleiQ6T311. HS.

Organism-specific databases

HPAiHPA072942.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353210.

Structurei

3D structure databases

ProteinModelPortaliQ6T311.
SMRiQ6T311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00880000137881.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ6T311.
KOiK07957.
OMAiAYCITDI.
OrthoDBiEOG091G0RFE.
PhylomeDBiQ6T311.
TreeFamiTF105469.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6T311-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPTWKALSH PAWPEEKNKQ ILVLGLDGAG KTSVLHSLAS NRVQHSVAPT
60 70 80 90 100
QGFHAVCINT EDSQMEFLEI GGSKPFRSYW EMYLSKGLLL IFVVDSADHS
110 120 130 140 150
RLPEAKKYLH QLIAANPVLP LVVFANKQDL EAAYHITDIH EALALSEVGN
160 170 180
DRKMFLFGTY LTKNGSEIPS TMQDAKDLIA QLAADVQ
Length:187
Mass (Da):20,755
Last modified:July 5, 2004 - v1
Checksum:i620432EC357013EA
GO
Isoform 2 (identifier: Q6T311-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):13,784
Checksum:i2D93520881AD20A5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0554131 – 64Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY439003 mRNA. Translation: AAS07576.1.
AC114766 Genomic DNA. No translation available.
AC108215 Genomic DNA. No translation available.
BM854066 mRNA. No translation available.
CCDSiCCDS59474.1. [Q6T311-2]
RefSeqiNP_996802.1. NM_206919.1. [Q6T311-2]
XP_005265777.1. XM_005265720.3. [Q6T311-2]
XP_006714099.1. XM_006714036.3. [Q6T311-2]
UniGeneiHs.444449.

Genome annotation databases

EnsembliENST00000360096; ENSP00000353210; ENSG00000196503. [Q6T311-2]
GeneIDi132946.
KEGGihsa:132946.
UCSCiuc003hby.2. human. [Q6T311-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiARL9_HUMAN
AccessioniPrimary (citable) accession number: Q6T311
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families