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Q6T310

- RSLBA_HUMAN

UniProt

Q6T310 - RSLBA_HUMAN

Protein

Ras-like protein family member 11A

Gene

RASL11A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 418GTPBy similarity
    Nucleotide bindingi81 – 855GTPBy similarity
    Nucleotide bindingi147 – 1504GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. GTP catabolic process Source: InterPro
    2. positive regulation of transcription from RNA polymerase I promoter Source: UniProtKB
    3. small GTPase mediated signal transduction Source: InterPro
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi3.6.5.2. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-like protein family member 11A
    Gene namesi
    Name:RASL11AImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:23802. RASL11A.

    Subcellular locationi

    Nucleusnucleolus By similarity
    Note: Associates with rDNA transcription unit throughout the cell cycle.By similarity

    GO - Cellular componenti

    1. membrane Source: InterPro
    2. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134906253.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242Ras-like protein family member 11APRO_0000308360Add
    BLAST

    Proteomic databases

    PaxDbiQ6T310.
    PRIDEiQ6T310.

    PTM databases

    PhosphoSiteiQ6T310.

    Expressioni

    Tissue specificityi

    Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells.2 Publications

    Developmental stagei

    Down-regulated during development of THP-1 monocytes into macrophages.1 Publication

    Inductioni

    Down-regulated by TGFB1.1 Publication

    Gene expression databases

    BgeeiQ6T310.
    CleanExiHS_RASL11A.
    GenevestigatoriQ6T310.

    Organism-specific databases

    HPAiHPA004859.

    Interactioni

    Subunit structurei

    Interacts with UBF/UBTF.By similarity

    Protein-protein interaction databases

    BioGridi132307. 1 interaction.
    MINTiMINT-5005255.
    STRINGi9606.ENSP00000241463.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6T310.
    SMRiQ6T310. Positions 27-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni17 – 241225Small GTPase-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Ras family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233973.
    HOVERGENiHBG108422.
    InParanoidiQ6T310.
    KOiK07852.
    OMAiVHPDSRA.
    OrthoDBiEOG70W3F5.
    PhylomeDBiQ6T310.
    TreeFamiTF318030.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6T310-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPLSMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGRVGK SAMIVRFLTK    50
    RFIGDYEPNT GKLYSRLVYV EGDQLSLQIQ DTPGGVQIQD SLPQVVDSLS 100
    KCVQWAEGFL LVYSITDYDS YLSIRPLYQH IRKVHPDSKA PVIIVGNKGD 150
    LLHARQVQTQ DGIQLANELG SLFLEISTSE NYEDVCDVFQ HLCKEVSKMH 200
    GLSGERRRAS IIPRPRSPNM QDLKRRFKQA LSPKVKAPSA LG 242
    Length:242
    Mass (Da):27,006
    Last modified:July 5, 2004 - v1
    Checksum:i0AC5B11854666BC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY439004 mRNA. Translation: AAS07577.1.
    AL159977 Genomic DNA. Translation: CAH73746.1.
    CH471075 Genomic DNA. Translation: EAX08402.1.
    BC132703 mRNA. Translation: AAI32704.1.
    BC136761 mRNA. Translation: AAI36762.1.
    CCDSiCCDS9321.1.
    RefSeqiNP_996563.1. NM_206827.1.
    UniGeneiHs.192131.

    Genome annotation databases

    EnsembliENST00000241463; ENSP00000241463; ENSG00000122035.
    GeneIDi387496.
    KEGGihsa:387496.
    UCSCiuc001urd.1. human.

    Polymorphism databases

    DMDMi74749333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY439004 mRNA. Translation: AAS07577.1 .
    AL159977 Genomic DNA. Translation: CAH73746.1 .
    CH471075 Genomic DNA. Translation: EAX08402.1 .
    BC132703 mRNA. Translation: AAI32704.1 .
    BC136761 mRNA. Translation: AAI36762.1 .
    CCDSi CCDS9321.1.
    RefSeqi NP_996563.1. NM_206827.1.
    UniGenei Hs.192131.

    3D structure databases

    ProteinModelPortali Q6T310.
    SMRi Q6T310. Positions 27-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132307. 1 interaction.
    MINTi MINT-5005255.
    STRINGi 9606.ENSP00000241463.

    PTM databases

    PhosphoSitei Q6T310.

    Polymorphism databases

    DMDMi 74749333.

    Proteomic databases

    PaxDbi Q6T310.
    PRIDEi Q6T310.

    Protocols and materials databases

    DNASUi 387496.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000241463 ; ENSP00000241463 ; ENSG00000122035 .
    GeneIDi 387496.
    KEGGi hsa:387496.
    UCSCi uc001urd.1. human.

    Organism-specific databases

    CTDi 387496.
    GeneCardsi GC13P027844.
    HGNCi HGNC:23802. RASL11A.
    HPAi HPA004859.
    MIMi 612403. gene.
    neXtProti NX_Q6T310.
    PharmGKBi PA134906253.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233973.
    HOVERGENi HBG108422.
    InParanoidi Q6T310.
    KOi K07852.
    OMAi VHPDSRA.
    OrthoDBi EOG70W3F5.
    PhylomeDBi Q6T310.
    TreeFami TF318030.

    Enzyme and pathway databases

    BRENDAi 3.6.5.2. 2681.

    Miscellaneous databases

    GenomeRNAii 387496.
    NextBioi 101340.
    PROi Q6T310.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6T310.
    CleanExi HS_RASL11A.
    Genevestigatori Q6T310.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors."
      Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M., Verjovski-Almeida S., Reis E.M.
      Biochem. Biophys. Res. Commun. 316:618-627(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    5. "Cloning, genomic organization, and tissue-specific expression of the RASL11B gene."
      Stolle K., Schnoor M., Fuellen G., Spitzer M., Cullen P., Lorkowski S.
      Biochim. Biophys. Acta 1769:514-524(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.

    Entry informationi

    Entry nameiRSLBA_HUMAN
    AccessioniPrimary (citable) accession number: Q6T310
    Secondary accession number(s): B2RN97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3