Reviewed, UniProtKB/Swiss-Prot Q6T310 (RSLBA_HUMAN)

Names and origin

Protein names

Recommended name:
    Ras-like protein family member 11A

Gene names

Name:

RASL11A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells. Ref.1 Ref.5
Developmental stage	Down-regulated during development of THP-1 monocytes into macrophages. Ref.5
Induction	Down-regulated by TGFB1. Ref.5
Sequence similarities	Belongs to the small GTPase superfamily. Ras family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Gene Ontology (GO)
Biological process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Ras-like protein family member 11A		PRO_0000308360
Regions
	Nucleotide binding	34 – 41	8	GTP By similarity UniProtKB Q96A58
	Nucleotide binding	81 – 85	5	GTP By similarity UniProtKB Q96A58
	Nucleotide binding	147 – 150	4	GTP By similarity UniProtKB Q96A58
	Region	17 – 241	225	Small GTPase-like

Sequences

	Sequence		Length	Mass (Da)
	Q6T310-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0AC5B11854666BC1	FASTA	242	27,006
	10 20 30 40 50 60 MRPLSMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGRVGK SAMIVRFLTK RFIGDYEPNT 70 80 90 100 110 120 GKLYSRLVYV EGDQLSLQIQ DTPGGVQIQD SLPQVVDSLS KCVQWAEGFL LVYSITDYDS 130 140 150 160 170 180 YLSIRPLYQH IRKVHPDSKA PVIIVGNKGD LLHARQVQTQ DGIQLANELG SLFLEISTSE 190 200 210 220 230 240 NYEDVCDVFQ HLCKEVSKMH GLSGERRRAS IIPRPRSPNM QDLKRRFKQA LSPKVKAPSA LG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors." Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M., Verjovski-Almeida S., Reis E.M. Biochem. Biophys. Res. Commun. 316:618-627(2004) [PubMed: 15033445] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Cloning, genomic organization, and tissue-specific expression of the RASL11B gene." Stolle K., Schnoor M., Fuellen G., Spitzer M., Cullen P., Lorkowski S. Biochim. Biophys. Acta 1769:514-524(2007) [PubMed: 17628721] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY439004 mRNA. Translation: AAS07577.1. AL159977 Genomic DNA. Translation: CAH73746.1. CH471075 Genomic DNA. Translation: EAX08402.1. BC132703 mRNA. Translation: AAI32704.1. BC136761 mRNA. Translation: AAI36762.1.
IPI	IPI00156120.
RefSeq	NP_996563.1.
UniGene	Hs.192131
3D structure databases
HSSP	HSSP built from PDB template 1KAO based on UniProtKB P10114.
ModBase	Search...
Proteomic databases
PRIDE	Q6T310.
Genome annotation databases
Ensembl	ENSG00000122035. Homo sapiens. [Contig view]
GeneID	387496.
KEGG	hsa:387496.
Organism-specific databases
GeneCards	GC13P026742.
HGNC	HGNC:23802. RASL11A.
MIM	612403. gene.
PharmGKB	PA134906253.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q6T310.
HOVERGEN	Q6T310.
OMA	Q6T310. EGLQLAN.
Enzyme and pathway databases
BRENDA	3.6.5.2. 247.
Gene expression databases
ArrayExpress	Q6T310.
Bgee	Q6T310.
CleanEx	HS_RASL11A.
Family and domain databases
InterPro	IPR013753. Ras. IPR001806. Ras_GTPase. IPR005225. Small_GTP_bd. [Graphical view]
Pfam	PF00071. Ras. 2 hits. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51421. RAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	101340.
SOURCE	Search...

Entry information

Entry name

RSLBA_HUMAN

Accession

Primary (citable) accession number: Q6T310
Secondary accession number(s): B2RN97

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)