Reviewed,
UniProtKB/Swiss-Prot Q6T310 (RSLBA_HUMAN)
Last modified
June 16, 2009.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ras-like protein family member 11A | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 242 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Tissue specificity | Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells. Ref.1 Ref.5 |
| Developmental stage | Down-regulated during development of THP-1 monocytes into macrophages. Ref.5 |
| Induction | Down-regulated by TGFB1. Ref.5 |
| Sequence similarities | Belongs to the small GTPase superfamily. Ras family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | GTP-binding Nucleotide-binding |
| Gene Ontology (GO) | |
| Biological process | small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 242 | 242 | Ras-like protein family member 11A | PRO_0000308360 | |||||
Regions | |||||||||
| Nucleotide binding | 34 – 41 | 8 | GTP By similarity UniProtKB Q96A58 | ||||||
| Nucleotide binding | 81 – 85 | 5 | GTP By similarity UniProtKB Q96A58 | ||||||
| Nucleotide binding | 147 – 150 | 4 | GTP By similarity UniProtKB Q96A58 | ||||||
| Region | 17 – 241 | 225 | Small GTPase-like | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AY439004 mRNA. Translation: AAS07577.1. AL159977 Genomic DNA. Translation: CAH73746.1. CH471075 Genomic DNA. Translation: EAX08402.1. BC132703 mRNA. Translation: AAI32704.1. BC136761 mRNA. Translation: AAI36762.1. | |
| IPI | IPI00156120. |
| RefSeq | NP_996563.1. |
| UniGene | Hs.192131 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KAO based on UniProtKB P10114. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q6T310. |
Genome annotation databases | |
| Ensembl | ENSG00000122035. Homo sapiens. [Contig view] |
| GeneID | 387496. |
| KEGG | hsa:387496. |
Organism-specific databases | |
| GeneCards | GC13P026742. |
| HGNC | HGNC:23802. RASL11A. |
| MIM | 612403. gene. |
| PharmGKB | PA134906253. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q6T310. |
| HOVERGEN | Q6T310. |
| OMA | Q6T310. EGLQLAN. |
Enzyme and pathway databases | |
| BRENDA | 3.6.5.2. 247. |
Gene expression databases | |
| ArrayExpress | Q6T310. |
| Bgee | Q6T310. |
| CleanEx | HS_RASL11A. |
Family and domain databases | |
| InterPro | IPR013753. Ras. IPR001806. Ras_GTPase. IPR005225. Small_GTP_bd. [Graphical view] |
| Pfam | PF00071. Ras. 2 hits. [Graphical view] |
| PRINTS | PR00449. RASTRNSFRMNG. |
| TIGRFAMs | TIGR00231. small_GTP. 1 hit. |
| PROSITE | PS51421. RAS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 101340. |
| SOURCE | Search... |
Entry information
| Entry name | RSLBA_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6T310 Secondary accession number(s): B2RN97 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 13 Human chromosome 13: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


