Q6T310 (RSLBA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-like protein family member 11A

Gene names

Name:

RASL11A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription By similarity.
Subunit structure	Interacts with UBF/UBTF By similarity.
Subcellular location	Nucleus › nucleolus By similarity. Note: Associates with rDNA transcription unit throughout the cell cycle By similarity.
Tissue specificity	Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells. Ref.1 Ref.5
Developmental stage	Down-regulated during development of THP-1 monocytes into macrophages. Ref.5
Induction	Down-regulated by TGFB1. Ref.5
Sequence similarities	Belongs to the small GTPase superfamily. Ras family.
Caution	Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of transcription from RNA polymerase I promoter Inferred from sequence or structural similarity. Source: UniProtKB small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro nucleolus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Ras-like protein family member 11A		PRO_0000308360
Regions
	Nucleotide binding	34 – 41	8	GTP By similarity UniProtKB Q96A58
	Nucleotide binding	81 – 85	5	GTP By similarity UniProtKB Q96A58
	Nucleotide binding	147 – 150	4	GTP By similarity UniProtKB Q96A58
	Region	17 – 241	225	Small GTPase-like

Sequences

	Sequence		Length	Mass (Da)
	Q6T310 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0AC5B11854666BC1	FASTA	242	27,006
	10 20 30 40 50 60 MRPLSMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGRVGK SAMIVRFLTK RFIGDYEPNT 70 80 90 100 110 120 GKLYSRLVYV EGDQLSLQIQ DTPGGVQIQD SLPQVVDSLS KCVQWAEGFL LVYSITDYDS 130 140 150 160 170 180 YLSIRPLYQH IRKVHPDSKA PVIIVGNKGD LLHARQVQTQ DGIQLANELG SLFLEISTSE 190 200 210 220 230 240 NYEDVCDVFQ HLCKEVSKMH GLSGERRRAS IIPRPRSPNM QDLKRRFKQA LSPKVKAPSA LG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors." Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M., Verjovski-Almeida S., Reis E.M. Biochem. Biophys. Res. Commun. 316:618-627(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Cloning, genomic organization, and tissue-specific expression of the RASL11B gene." Stolle K., Schnoor M., Fuellen G., Spitzer M., Cullen P., Lorkowski S. Biochim. Biophys. Acta 1769:514-524(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY439004 mRNA. Translation: AAS07577.1. AL159977 Genomic DNA. Translation: CAH73746.1. CH471075 Genomic DNA. Translation: EAX08402.1. BC132703 mRNA. Translation: AAI32704.1. BC136761 mRNA. Translation: AAI36762.1.
IPI	IPI00156120.
RefSeq	NP_996563.1. NM_206827.1.
UniGene	Hs.192131.
3D structure databases
ProteinModelPortal	Q6T310.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-5005255.
STRING	9606.ENSP00000241463.
PTM databases
PhosphoSite	Q6T310.
Polymorphism databases
DMDM	74749333.
Proteomic databases
PaxDb	Q6T310.
PRIDE	Q6T310.
Protocols and materials databases
DNASU	387496.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000241463; ENSP00000241463; ENSG00000122035.
GeneID	387496.
KEGG	hsa:387496.
UCSC	uc001urd.1. human.
Organism-specific databases
CTD	387496.
GeneCards	GC13P027844.
HGNC	HGNC:23802. RASL11A.
HPA	HPA004859.
MIM	612403. gene.
neXtProt	NX_Q6T310.
PharmGKB	PA134906253.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233973.
HOVERGEN	HBG108422.
InParanoid	Q6T310.
KO	K07852.
OMA	VHPDSRA.
OrthoDB	EOG48GW44.
PhylomeDB	Q6T310.
Enzyme and pathway databases
BRENDA	3.6.5.2. 2681.
Gene expression databases
Bgee	Q6T310.
CleanEx	HS_RASL11A.
Genevestigator	Q6T310.
Family and domain databases
InterPro	IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR020849. Small_GTPase_Ras. [Graphical view]
PANTHER	PTHR24070. PTHR24070. 1 hit.
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51421. RAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	387496.
NextBio	101340.
SOURCE	Search...

Entry information

Entry name

RSLBA_HUMAN

Accession

Primary (citable) accession number: Q6T310
Secondary accession number(s): B2RN97

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.