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Protein

Ras-like protein family member 11A

Gene

RASL11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 418GTPBy similarity
Nucleotide bindingi81 – 855GTPBy similarity
Nucleotide bindingi147 – 1504GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. GTP catabolic process Source: InterPro
  2. positive regulation of transcription from RNA polymerase I promoter Source: UniProtKB
  3. small GTPase mediated signal transduction Source: InterPro
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.2. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein family member 11A
Gene namesi
Name:RASL11AImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:23802. RASL11A.

Subcellular locationi

Nucleusnucleolus By similarity
Note: Associates with rDNA transcription unit throughout the cell cycle.By similarity

GO - Cellular componenti

  1. membrane Source: InterPro
  2. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134906253.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Ras-like protein family member 11APRO_0000308360Add
BLAST

Proteomic databases

PaxDbiQ6T310.
PRIDEiQ6T310.

PTM databases

PhosphoSiteiQ6T310.

Expressioni

Tissue specificityi

Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells.2 Publications

Developmental stagei

Down-regulated during development of THP-1 monocytes into macrophages.1 Publication

Inductioni

Down-regulated by TGFB1.1 Publication

Gene expression databases

BgeeiQ6T310.
CleanExiHS_RASL11A.
GenevestigatoriQ6T310.

Organism-specific databases

HPAiHPA004859.

Interactioni

Subunit structurei

Interacts with UBF/UBTF.By similarity

Protein-protein interaction databases

BioGridi132307. 1 interaction.
MINTiMINT-5005255.
STRINGi9606.ENSP00000241463.

Structurei

3D structure databases

ProteinModelPortaliQ6T310.
SMRiQ6T310. Positions 27-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 241225Small GTPase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG108422.
InParanoidiQ6T310.
KOiK07852.
OMAiYLCKEVS.
OrthoDBiEOG70W3F5.
PhylomeDBiQ6T310.
TreeFamiTF318030.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6T310-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPLSMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGRVGK SAMIVRFLTK
60 70 80 90 100
RFIGDYEPNT GKLYSRLVYV EGDQLSLQIQ DTPGGVQIQD SLPQVVDSLS
110 120 130 140 150
KCVQWAEGFL LVYSITDYDS YLSIRPLYQH IRKVHPDSKA PVIIVGNKGD
160 170 180 190 200
LLHARQVQTQ DGIQLANELG SLFLEISTSE NYEDVCDVFQ HLCKEVSKMH
210 220 230 240
GLSGERRRAS IIPRPRSPNM QDLKRRFKQA LSPKVKAPSA LG
Length:242
Mass (Da):27,006
Last modified:July 5, 2004 - v1
Checksum:i0AC5B11854666BC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY439004 mRNA. Translation: AAS07577.1.
AL159977 Genomic DNA. Translation: CAH73746.1.
CH471075 Genomic DNA. Translation: EAX08402.1.
BC132703 mRNA. Translation: AAI32704.1.
BC136761 mRNA. Translation: AAI36762.1.
CCDSiCCDS9321.1.
RefSeqiNP_996563.1. NM_206827.1.
UniGeneiHs.192131.

Genome annotation databases

EnsembliENST00000241463; ENSP00000241463; ENSG00000122035.
GeneIDi387496.
KEGGihsa:387496.
UCSCiuc001urd.1. human.

Polymorphism databases

DMDMi74749333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY439004 mRNA. Translation: AAS07577.1.
AL159977 Genomic DNA. Translation: CAH73746.1.
CH471075 Genomic DNA. Translation: EAX08402.1.
BC132703 mRNA. Translation: AAI32704.1.
BC136761 mRNA. Translation: AAI36762.1.
CCDSiCCDS9321.1.
RefSeqiNP_996563.1. NM_206827.1.
UniGeneiHs.192131.

3D structure databases

ProteinModelPortaliQ6T310.
SMRiQ6T310. Positions 27-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132307. 1 interaction.
MINTiMINT-5005255.
STRINGi9606.ENSP00000241463.

PTM databases

PhosphoSiteiQ6T310.

Polymorphism databases

DMDMi74749333.

Proteomic databases

PaxDbiQ6T310.
PRIDEiQ6T310.

Protocols and materials databases

DNASUi387496.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241463; ENSP00000241463; ENSG00000122035.
GeneIDi387496.
KEGGihsa:387496.
UCSCiuc001urd.1. human.

Organism-specific databases

CTDi387496.
GeneCardsiGC13P027844.
HGNCiHGNC:23802. RASL11A.
HPAiHPA004859.
MIMi612403. gene.
neXtProtiNX_Q6T310.
PharmGKBiPA134906253.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG108422.
InParanoidiQ6T310.
KOiK07852.
OMAiYLCKEVS.
OrthoDBiEOG70W3F5.
PhylomeDBiQ6T310.
TreeFamiTF318030.

Enzyme and pathway databases

BRENDAi3.6.5.2. 2681.

Miscellaneous databases

GenomeRNAii387496.
NextBioi101340.
PROiQ6T310.
SOURCEiSearch...

Gene expression databases

BgeeiQ6T310.
CleanExiHS_RASL11A.
GenevestigatoriQ6T310.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors."
    Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M., Verjovski-Almeida S., Reis E.M.
    Biochem. Biophys. Res. Commun. 316:618-627(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  5. "Cloning, genomic organization, and tissue-specific expression of the RASL11B gene."
    Stolle K., Schnoor M., Fuellen G., Spitzer M., Cullen P., Lorkowski S.
    Biochim. Biophys. Acta 1769:514-524(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.

Entry informationi

Entry nameiRSLBA_HUMAN
AccessioniPrimary (citable) accession number: Q6T310
Secondary accession number(s): B2RN97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.