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Q6T310 (RSLBA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-like protein family member 11A
Gene names
Name:RASL11A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription By similarity.

Subunit structure

Interacts with UBF/UBTF By similarity.

Subcellular location

Nucleusnucleolus By similarity. Note: Associates with rDNA transcription unit throughout the cell cycle By similarity.

Tissue specificity

Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells. Ref.1 Ref.5

Developmental stage

Down-regulated during development of THP-1 monocytes into macrophages. Ref.5

Induction

Down-regulated by TGFB1. Ref.5

Sequence similarities

Belongs to the small GTPase superfamily. Ras family.

Caution

Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Ras-like protein family member 11A
PRO_0000308360

Regions

Nucleotide binding34 – 418GTP By similarity UniProtKB Q96A58
Nucleotide binding81 – 855GTP By similarity UniProtKB Q96A58
Nucleotide binding147 – 1504GTP By similarity UniProtKB Q96A58
Region17 – 241225Small GTPase-like

Sequences

Sequence LengthMass (Da)Tools
Q6T310 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 0AC5B11854666BC1

FASTA24227,006
        10         20         30         40         50         60 
MRPLSMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGRVGK SAMIVRFLTK RFIGDYEPNT 

        70         80         90        100        110        120 
GKLYSRLVYV EGDQLSLQIQ DTPGGVQIQD SLPQVVDSLS KCVQWAEGFL LVYSITDYDS 

       130        140        150        160        170        180 
YLSIRPLYQH IRKVHPDSKA PVIIVGNKGD LLHARQVQTQ DGIQLANELG SLFLEISTSE 

       190        200        210        220        230        240 
NYEDVCDVFQ HLCKEVSKMH GLSGERRRAS IIPRPRSPNM QDLKRRFKQA LSPKVKAPSA 


LG 

« Hide

References

« Hide 'large scale' references
[1]"Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors."
Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M., Verjovski-Almeida S., Reis E.M.
Biochem. Biophys. Res. Commun. 316:618-627(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Cloning, genomic organization, and tissue-specific expression of the RASL11B gene."
Stolle K., Schnoor M., Fuellen G., Spitzer M., Cullen P., Lorkowski S.
Biochim. Biophys. Acta 1769:514-524(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY439004 mRNA. Translation: AAS07577.1.
AL159977 Genomic DNA. Translation: CAH73746.1.
CH471075 Genomic DNA. Translation: EAX08402.1.
BC132703 mRNA. Translation: AAI32704.1.
BC136761 mRNA. Translation: AAI36762.1.
CCDSCCDS9321.1.
RefSeqNP_996563.1. NM_206827.1.
UniGeneHs.192131.

3D structure databases

ProteinModelPortalQ6T310.
SMRQ6T310. Positions 27-198.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid132307. 1 interaction.
MINTMINT-5005255.
STRING9606.ENSP00000241463.

PTM databases

PhosphoSiteQ6T310.

Polymorphism databases

DMDM74749333.

Proteomic databases

PaxDbQ6T310.
PRIDEQ6T310.

Protocols and materials databases

DNASU387496.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000241463; ENSP00000241463; ENSG00000122035.
GeneID387496.
KEGGhsa:387496.
UCSCuc001urd.1. human.

Organism-specific databases

CTD387496.
GeneCardsGC13P027844.
HGNCHGNC:23802. RASL11A.
HPAHPA004859.
MIM612403. gene.
neXtProtNX_Q6T310.
PharmGKBPA134906253.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233973.
HOVERGENHBG108422.
InParanoidQ6T310.
KOK07852.
OMAVHPDSRA.
OrthoDBEOG70W3F5.
PhylomeDBQ6T310.
TreeFamTF318030.

Enzyme and pathway databases

BRENDA3.6.5.2. 2681.

Gene expression databases

BgeeQ6T310.
CleanExHS_RASL11A.
GenevestigatorQ6T310.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERPTHR24070. PTHR24070. 1 hit.
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi387496.
NextBio101340.
PROQ6T310.
SOURCESearch...

Entry information

Entry nameRSLBA_HUMAN
AccessionPrimary (citable) accession number: Q6T310
Secondary accession number(s): B2RN97
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM