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Protein

GDP-6-deoxy-D-mannose reductase

Gene

rmd

Organism
Aneurinibacillus thermoaerophilus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Reductase that catalyzes the conversion of GDP-6-deoxy-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (GDP-D-rhamnose).2 Publications

Catalytic activityi

GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32NADP1
Binding sitei140NADP1
Binding sitei169Substrate1 Publication1
Binding sitei183Substrate1 Publication1
Binding sitei209Substrate1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 12NADP2
Nucleotide bindingi47 – 48NADP2
Nucleotide bindingi71 – 73NADP3

GO - Molecular functioni

  • GDP-4-dehydro-6-deoxy-D-mannose reductase activity Source: UniProtKB

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-6-deoxy-D-mannose reductase (EC:1.1.1.281)
Gene namesi
Name:rmd
OrganismiAneurinibacillus thermoaerophilus
Taxonomic identifieri143495 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeAneurinibacillus groupAneurinibacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004190371 – 309GDP-6-deoxy-D-mannose reductaseAdd BLAST309

Structurei

Secondary structure

1309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Turni7 – 9Combined sources3
Helixi11 – 22Combined sources12
Beta strandi26 – 32Combined sources7
Beta strandi41 – 45Combined sources5
Helixi51 – 61Combined sources11
Beta strandi64 – 68Combined sources5
Helixi75 – 78Combined sources4
Helixi82 – 103Combined sources22
Beta strandi108 – 114Combined sources7
Helixi115 – 117Combined sources3
Helixi123 – 125Combined sources3
Helixi139 – 158Combined sources20
Beta strandi161 – 167Combined sources7
Beta strandi169 – 171Combined sources3
Helixi180 – 192Combined sources13
Beta strandi198 – 203Combined sources6
Beta strandi208 – 213Combined sources6
Helixi214 – 227Combined sources14
Beta strandi233 – 237Combined sources5
Beta strandi241 – 243Combined sources3
Helixi244 – 254Combined sources11
Beta strandi255 – 257Combined sources3
Beta strandi260 – 263Combined sources4
Helixi265 – 267Combined sources3
Helixi281 – 287Combined sources7
Helixi295 – 307Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PK3X-ray1.82A/B1-309[»]
ProteinModelPortaliQ6T1X6.
SMRiQ6T1X6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6T1X6.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni114 – 115Substrate binding2
Regioni269 – 272Substrate binding4

Sequence similaritiesi

Phylogenomic databases

KOiK15856.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF16363. GDP_Man_Dehyd. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6T1X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALITGVAG FVGKYLANHL TEQNVEVFGT SRNNEAKLPN VEMISLDIMD
60 70 80 90 100
SQRVKKVISD IKPDYIFHLA AKSSVKDSWL NKKGTFSTNV FGTLHVLDAV
110 120 130 140 150
RDSNLDCRIL TIGSSEEYGM ILPEESPVSE ENQLRPMSPY GVSKASVGML
160 170 180 190 200
ARQYVKAYGM DIIHTRTFNH IGPGQSLGFV TQDFAKQIVD IEMEKQEPII
210 220 230 240 250
KVGNLEAVRD FTDVRDIVQA YWLLSQYGKT GDVYNVCSGI GTRIQDVLDL
260 270 280 290 300
LLAMANVKID TELNPLQLRP SEVPTLIGSN KRLKDSTGWK PRIPLEKSLF

EILQSYRQA
Length:309
Mass (Da):34,556
Last modified:July 5, 2004 - v1
Checksum:i737FFC9390B14868
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY442352 Genomic DNA. Translation: AAS55712.1.

Genome annotation databases

KEGGiag:AAS55712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY442352 Genomic DNA. Translation: AAS55712.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PK3X-ray1.82A/B1-309[»]
ProteinModelPortaliQ6T1X6.
SMRiQ6T1X6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAS55712.

Phylogenomic databases

KOiK15856.

Miscellaneous databases

EvolutionaryTraceiQ6T1X6.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF16363. GDP_Man_Dehyd. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRMD_ANETH
AccessioniPrimary (citable) accession number: Q6T1X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.