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Q6T1W8

- FDTA_ANETH

UniProt

Q6T1W8 - FDTA_ANETH

Protein

TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase

Gene

fdtA

Organism
Aneurinibacillus thermoaerophilus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Mediates the isomerization of dTDP-6-deoxy-D-xylohex-4-ulose into dTDP-6-deoxy-D-xylohex-3-ulose in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose, a glycan chain of the S-layer.2 Publications

    Catalytic activityi

    dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Proton acceptor1 Publication

    GO - Molecular functioni

    1. isomerase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (EC:5.3.2.3)
    Alternative name(s):
    dTDP-6-deoxy-3,4-keto-hexulose isomerase
    Gene namesi
    Name:fdtA
    OrganismiAneurinibacillus thermoaerophilus
    Taxonomic identifieri143495 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeAneurinibacillus groupAneurinibacillus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi49 – 491H → N: Loss of catalytic activity. 1 Publication
    Mutagenesisi51 – 511H → N: Retains some catalytic activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerasePRO_0000421823Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Structurei

    Secondary structure

    1
    139
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 74
    Beta strandi10 – 134
    Beta strandi16 – 227
    Turni23 – 253
    Beta strandi26 – 294
    Beta strandi33 – 397
    Beta strandi46 – 538
    Beta strandi56 – 638
    Beta strandi65 – 706
    Beta strandi75 – 806
    Beta strandi85 – 895
    Beta strandi94 – 985
    Beta strandi105 – 1128
    Helixi116 – 1183
    Helixi123 – 13513

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PA7X-ray1.50A/B1-139[»]
    2PAEX-ray2.50A/B1-139[»]
    2PAKX-ray2.40A/B1-139[»]
    2PAMX-ray2.50A/B1-139[»]
    ProteinModelPortaliQ6T1W8.
    SMRiQ6T1W8. Positions 2-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6T1W8.

    Family & Domainsi

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    IPR008894. WxcM_C.
    [Graphical view]
    PfamiPF05523. FdtA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6T1W8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENKVINFKK IIDSRGSLVA IEENKNIPFS IKRVYYIFDT KGEEPRGFHA    50
    HKKLEQVLVC LNGSCRVILD DGNIIQEITL DSPAVGLYVG PAVWHEMHDF 100
    SSDCVMMVLA SDYYDETDYI RQYDNFKKYI AKINLEKEG 139
    Length:139
    Mass (Da):16,042
    Last modified:July 5, 2004 - v1
    Checksum:iEC32CB06F863F137
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY442352 Genomic DNA. Translation: AAS55720.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY442352 Genomic DNA. Translation: AAS55720.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PA7 X-ray 1.50 A/B 1-139 [» ]
    2PAE X-ray 2.50 A/B 1-139 [» ]
    2PAK X-ray 2.40 A/B 1-139 [» ]
    2PAM X-ray 2.50 A/B 1-139 [» ]
    ProteinModelPortali Q6T1W8.
    SMRi Q6T1W8. Positions 2-136.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-17003.

    Miscellaneous databases

    EvolutionaryTracei Q6T1W8.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    IPR008894. WxcM_C.
    [Graphical view ]
    Pfami PF05523. FdtA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T."
      Pfoestl A., Hofinger A., Kosma P., Messner P.
      J. Biol. Chem. 278:26410-26417(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY.
      Strain: L420-91T.
    2. "The x-ray structure of dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase."
      Davis M.L., Thoden J.B., Holden H.M.
      J. Biol. Chem. 282:19227-19236(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS), SUBUNIT, ACTIVE SITE, FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF HIS-49 AND HIS-51.

    Entry informationi

    Entry nameiFDTA_ANETH
    AccessioniPrimary (citable) accession number: Q6T1W8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2013
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3