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Q6T1W8

- FDTA_ANETH

UniProt

Q6T1W8 - FDTA_ANETH

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Protein

TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase

Gene

fdtA

Organism
Aneurinibacillus thermoaerophilus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Mediates the isomerization of dTDP-6-deoxy-D-xylohex-4-ulose into dTDP-6-deoxy-D-xylohex-3-ulose in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose, a glycan chain of the S-layer.2 Publications

Catalytic activityi

dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton acceptor1 Publication

GO - Molecular functioni

  1. isomerase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17003.

Names & Taxonomyi

Protein namesi
Recommended name:
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (EC:5.3.2.3)
Alternative name(s):
dTDP-6-deoxy-3,4-keto-hexulose isomerase
Gene namesi
Name:fdtA
OrganismiAneurinibacillus thermoaerophilus
Taxonomic identifieri143495 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeAneurinibacillus groupAneurinibacillus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi49 – 491H → N: Loss of catalytic activity. 1 Publication
Mutagenesisi51 – 511H → N: Retains some catalytic activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerasePRO_0000421823Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1
139
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74
Beta strandi10 – 134
Beta strandi16 – 227
Turni23 – 253
Beta strandi26 – 294
Beta strandi33 – 397
Beta strandi46 – 538
Beta strandi56 – 638
Beta strandi65 – 706
Beta strandi75 – 806
Beta strandi85 – 895
Beta strandi94 – 985
Beta strandi105 – 1128
Helixi116 – 1183
Helixi123 – 13513

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PA7X-ray1.50A/B1-139[»]
2PAEX-ray2.50A/B1-139[»]
2PAKX-ray2.40A/B1-139[»]
2PAMX-ray2.50A/B1-139[»]
ProteinModelPortaliQ6T1W8.
SMRiQ6T1W8. Positions 2-136.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6T1W8.

Family & Domainsi

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
IPR008894. WxcM_C.
[Graphical view]
PfamiPF05523. FdtA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6T1W8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENKVINFKK IIDSRGSLVA IEENKNIPFS IKRVYYIFDT KGEEPRGFHA
60 70 80 90 100
HKKLEQVLVC LNGSCRVILD DGNIIQEITL DSPAVGLYVG PAVWHEMHDF
110 120 130
SSDCVMMVLA SDYYDETDYI RQYDNFKKYI AKINLEKEG
Length:139
Mass (Da):16,042
Last modified:July 5, 2004 - v1
Checksum:iEC32CB06F863F137
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY442352 Genomic DNA. Translation: AAS55720.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY442352 Genomic DNA. Translation: AAS55720.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PA7 X-ray 1.50 A/B 1-139 [» ]
2PAE X-ray 2.50 A/B 1-139 [» ]
2PAK X-ray 2.40 A/B 1-139 [» ]
2PAM X-ray 2.50 A/B 1-139 [» ]
ProteinModelPortali Q6T1W8.
SMRi Q6T1W8. Positions 2-136.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17003.

Miscellaneous databases

EvolutionaryTracei Q6T1W8.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
IPR008894. WxcM_C.
[Graphical view ]
Pfami PF05523. FdtA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T."
    Pfoestl A., Hofinger A., Kosma P., Messner P.
    J. Biol. Chem. 278:26410-26417(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY.
    Strain: L420-91T.
  2. "The x-ray structure of dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase."
    Davis M.L., Thoden J.B., Holden H.M.
    J. Biol. Chem. 282:19227-19236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS), SUBUNIT, ACTIVE SITE, FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF HIS-49 AND HIS-51.

Entry informationi

Entry nameiFDTA_ANETH
AccessioniPrimary (citable) accession number: Q6T1W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3