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Protein

Protein UL11

Gene

UL11

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the modulation of host immune response by modulating T-cell function. Interacts with host PTPRC/CD45 and thereby reduces host TCR signaling and T-cell proliferation.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL11
Gene namesi
Name:UL11
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 224ExtracellularSequence analysisAdd BLAST193
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 272CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000041831332 – 272Protein UL11Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi100N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with host PTPRC; this interaction affects T-cell signaling.1 Publication

Structurei

3D structure databases

SMRiQ6SWB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi147 – 150Poly-Thr4
Compositional biasi154 – 164Poly-ThrAdd BLAST11
Compositional biasi167 – 175Poly-Thr9

Sequence similaritiesi

Belongs to the RL11 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK21042.
OrthoDBiVOG090000SW.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6SWB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFRYITFHR EKVLYLTAAC IFGVYISLHD ACIPVVGKIG TNVTLNAVDV
60 70 80 90 100
LPPRDQVRWS YGPGGQGYML CIFTGTSTTT FNNTRFNFSC LSNYSLLLIN
110 120 130 140 150
VTTQYSTTYR TMTSLDHWLH QRHNHGSRWT LDTCYNLTVN ENGTFPTTTT
160 170 180 190 200
KKPTTTTRTT TTTTQRTTTT RTTTTAKKTT ISTTHHKHPS PKKSTTPNSH
210 220 230 240 250
VEHHVGFEAT AAETPLQPSP QHQHLATHAL WVLAVVIVII IIIIFYFRIP
260 270
QKLWLLWQHD KHGIVLIPQT DL
Length:272
Mass (Da):30,881
Last modified:July 5, 2004 - v1
Checksum:i50B9D252EB1EC5DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31577.1.
RefSeqiYP_081471.1. NC_006273.2.

Genome annotation databases

GeneIDi3077560.
KEGGivg:3077560.

Similar proteinsi

Entry informationi

Entry nameiUL11P_HCMVM
AccessioniPrimary (citable) accession number: Q6SWB9
Secondary accession number(s): D2K3I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families