Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G-protein coupled receptor homolog UL33

Gene

UL33

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

G-protein-coupled receptor (vGPCR) that constitutively activates multiple signaling pathways in a ligand independent manner. For example, promotes phospholipase C and cAMP-responsive element (CRE) pathway activation. Therefore, greatly contributes to viral pathogenesis. Inhibits US28-mediated NF-kappa-B activation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processHost-virus interaction, Inhibition of host chemokines by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor homolog UL33
Gene namesi
Name:UL33
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35Virion surfaceSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini57 – 80IntravirionSequence analysisAdd BLAST24
Transmembranei81 – 101Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini102 – 106Virion surfaceSequence analysis5
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 147IntravirionSequence analysisAdd BLAST20
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 206Virion surfaceSequence analysisAdd BLAST38
Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini228 – 244IntravirionSequence analysisAdd BLAST17
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 292Virion surfaceSequence analysisAdd BLAST27
Transmembranei293 – 313Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini314 – 412IntravirionSequence analysisAdd BLAST99

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004164411 – 412G-protein coupled receptor homolog UL33Add BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi23N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Disulfide bondi105 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Heterodimerizes with US28.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6SW98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000NY.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6SW98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTIIHNTTN RSTDTPHVNI TCNITEPLSA IRTTEAVINT FIIFVGGPLN
60 70 80 90 100
AIVLITQLLT NRVLGYSTPT IYMTNLYSTN FLTLTVLPFI VLSNQWLLPA
110 120 130 140 150
SVASCKFLSV IYYSSCTVGF ATVALIAADR YRVLHKRTYA RQSYRSTYII
160 170 180 190 200
LLLTWFAGLI FSMPAAVYTT VVIHNGTNGQ SSNGHATCVL YFIADEVYTV
210 220 230 240 250
LLSWKVLLTL VWGAAPVIMM TWFYAFFYST VQRASQKQRS RTLTFVSVLL
260 270 280 290 300
ISFVALQTPY VSIMIFNSYA TAAWPMDCEH LTLRRTIGTL SRLVPHLHCL
310 320 330 340 350
INPILYALLG HDFLQRMRQC FRGQLLDRRA FLRSQQNQRA TAETNLAAGN
360 370 380 390 400
NSQSVATSLD TSSKNCNQHA KRSVSFNFPS GTWKGGQKTA SNDTSTKIPH
410
RLSQSHHNLS GV
Length:412
Mass (Da):46,080
Last modified:July 5, 2004 - v1
Checksum:i6ADD072CF5E5C928
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31598.1.
RefSeqiYP_081492.1. NC_006273.2.

Genome annotation databases

GeneIDi3077468.
KEGGivg:3077468.

Similar proteinsi

Entry informationi

Entry nameiUL33_HCMVM
AccessioniPrimary (citable) accession number: Q6SW98
Secondary accession number(s): D2K3K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families