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Protein

Ribonucleoside-diphosphate reductase large subunit-like protein

Gene

RIR1

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.UniRule annotation

Caution

Lacks the conserved sequence Asn-x-Cys-x-Glu essential for ribonucleotide reductase activity.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunit-like proteinUniRule annotation
Gene namesi
Name:RIR1UniRule annotation
Synonyms:UL45
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004183121 – 906Ribonucleoside-diphosphate reductase large subunit-like proteinAdd BLAST906

Proteomic databases

PRIDEiQ6SW87

Expressioni

Keywords - Developmental stagei

Late protein

Structurei

3D structure databases

ProteinModelPortaliQ6SW87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900001D

Family and domain databases

HAMAPiMF_04027 HSV_RIR1_betahv, 1 hit
InterProiView protein in InterPro
IPR034716 HSV_RIR1_betahv
IPR000788 RNR_lg_C
PfamiView protein in Pfam
PF02867 Ribonuc_red_lgC, 1 hit
PRINTSiPR01183 RIBORDTASEM1
PROSITEiView protein in PROSITE
PS00089 RIBORED_LARGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6SW87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPADADEEQ RVSSVPAHRC RPGRIPSRSA ETETEESSAE VAADTIGGDD
60 70 80 90 100
SELEEGPLPG GDKEASAGNT NVSSGVACVA GFTSGGGVVS WRPESPSPDG
110 120 130 140 150
TPSVLSLTRD SGPAVPSRGG RVSSGLSTFN PAGATRMELD SVEEEDDFGA
160 170 180 190 200
SLCKVSPPIQ AMRMLMGKKC HCHGYWGKFR FCGVQEPARE LPSDRNALWR
210 220 230 240 250
EMDTVSRHSA GLGSFRLFQL IMRHGPCLIR HSPRCDLLLG RFYFKANWAR
260 270 280 290 300
ESRTPLCYAS ELCDESVRRF VLRHMEDLPK LAEETARFVE LAGCWGLYAA
310 320 330 340 350
ILCLDKVCRQ LHGQDESPGG VFLRIAVALT AAIENSRHSR IYRFHLDARF
360 370 380 390 400
EGEVLESVLK RCRDGQLSLS TFTMSTVGFD RVPQYDFLIS ADPFSRDASW
410 420 430 440 450
AAMCKWMSTL SCGVSVSVNV TRLNADVNSV IRCLGGYCDL IREKEVHRPV
460 470 480 490 500
VRVFVDMWDV AAIRVINFIL KESTSELTGV CYAFNVPSVL MKRYRAREQR
510 520 530 540 550
YSLFGRPVSR RLSDLGQESA FEKEYSRCEQ SCPKVVVNTD DFLKKMLLCA
560 570 580 590 600
LKGRASVVFV HHVVKYSIMA DSVCLPPCLS PDMASCHFGE CDMPVQRLTV
610 620 630 640 650
NVARCVFARS DEQKLHLPDV VLGNTRRYFD LSVLRELVTE AVVWGNARLD
660 670 680 690 700
ALMSASEWWV ESALEKLRPL HIGVAGLHTA LMRLGFTYFA SWDLIERIFE
710 720 730 740 750
HMYFAAVRAS VDLCKSGLPR CEWFERTIYQ EGKFIFELYR LPRLSIASAR
760 770 780 790 800
WEALRADMLE FGLRNCQFLA VGPDDEVAHL WGVTPSVWAS RGTVFEEETV
810 820 830 840 850
WSLCPPNREC YFPTVVRRPL RVPVVNYAWL EQHQEEGKAT QCLFQAAPAI
860 870 880 890 900
QNDVEMAAVN LSVFVDQCVA LVFYYDSGMT PDVLLARMLK WYHWRFKVGV

YKYCAS
Length:906
Mass (Da):101,698
Last modified:July 5, 2004 - v1
Checksum:iB99A2500AB30F063
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31609.1
RefSeqiYP_081503.1, NC_006273.2

Genome annotation databases

GeneIDi3077444
KEGGivg:3077444

Similar proteinsi

Entry informationi

Entry nameiRIR1_HCMVM
AccessioniPrimary (citable) accession number: Q6SW87
Secondary accession number(s): D2K3L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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