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Q6SW84

- DEN_HCMVM

UniProt

Q6SW84 - DEN_HCMVM

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Protein
Deneddylase
Gene
UL48
Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei24 – 241 By similarity
Active sitei160 – 1601 By similarity
Active sitei162 – 1621 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
Alternative name(s):
Large tegument protein
Short name:
LTP
Gene namesi
Name:UL48
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000938: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. viral tegument Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22412241Deneddylase
PRO_0000416709Add
BLAST

Interactioni

Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6SW84.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 226223Peptidase C76
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili544 – 57128 Reviewed prediction
Add
BLAST
Coiled coili765 – 79228 Reviewed prediction
Add
BLAST
Coiled coili1167 – 120034 Reviewed prediction
Add
BLAST
Coiled coili1240 – 127233 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi244 – 2474Poly-Thr
Compositional biasi325 – 3284Poly-Ser
Compositional biasi785 – 7895Poly-Glu
Compositional biasi1921 – 193010Poly-Thr
Compositional biasi2133 – 21375Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR006928. Pept_C76_UL36-USP.
[Graphical view]
PfamiPF04843. Herpes_teg_N. 1 hit.
[Graphical view]
PROSITEiPS51521. HTUSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6SW84-1 [UniParc]FASTAAdd to Basket

« Hide

MKVTQASCHQ GDIARFGARA GNQCVCNGIM FLHALHLGGT SAVLQTEALD     50
AIMEEGARLD ARLERELQKK LPAGGRLPVY RLGDEVPRRL ESRFGRTVHA 100
LSRPFNGTTE TCDLDGYMCP GIFDFLRYAH AKPRPTYVLV TVNSLARAVV 150
FTEDHMLVFD PHSSAECHNA AVYHCEGLHQ VLMVLTGFGV QLSPAFYYEA 200
LFLYMLDVAT VPEAEIAARL VSTYRDRDID LTGVVRESAD TAATTTTAAP 250
SLPPLPDPIV DPGCPPGVAP SIPVYDPSSS PKKTPEKRRK DLSGSKHGGK 300
KKPPSTTSKT LATASSSPSA IAAASSSSAV PPSYSCGEGA LPALGRYQQL 350
VDEVEQELKA LTLPPLPANT SAWTLHAAGT ESGANAATAT APSFDEAFLT 400
DRLQQLIIHA VNQRSCLRRP CGPQSAAQQA VRAYLGLSKK LDAFLLNWLH 450
HGLDLQRMHD YLSHKTTKGT YSTLDRALLE KMQVVFDPYG RQHGPALIAW 500
VEEMLRYVES KPTNELSQRL QRFVTKRPMP VSDSFVCLRP VDFQRLTQVI 550
EQRRRVLQRQ REEYHGVYEH LAGLITSIDI HDLDASDLNR REILKALQPL 600
DDNAKQELFR LGNAKMLELQ MDLDRLSTQL LTRVHNHILN GFLPVEDLKQ 650
MERVVEQVLR LFYDLRDLKL CDGSYEEGFV VIREQLSYLM TGTVRDNVPL 700
LQEILQLRHA YQQATQQNEG RLTQIHDLLH VIETLVRDPG SRGSALTLAL 750
VQEQLAQLEA LGGLQLPEVQ QRLQNAQLAL SRLYEEEEET QRFLDGLSYD 800
DPPTEQTIKR HPQLREMLRR DEQTRLRLIN AVLSMFHTLV MRLARDESPR 850
PTFFDAVSLL LQQLPPDSHE REDLRAANAT YAQMVKKLEQ IEKAGTGASE 900
KRFQALRELV YFFRNHEYFF QHMVGRLGVG PQVTELYERY QHEMEEQHLE 950
RLEREWQEEA GKLTVTSVED VQRVLARAPS HRVMHQMQQT LTTKMQDFLD 1000
KEKRKQEEQQ RQLLDGYQKK VQQDLQRVVD AVKGEMLSTI PHQPLEATLE 1050
LLLGLDQRAQ PLLDKFNQDL LSALQQLSKK LDGRINECLH GVLTGDVERR 1100
CHPHREAAMQ TQASLNHLDQ ILGPQLLIHE TQQALQHAVH QAQFIEKCQQ 1150
GDPTTAITGS EFESDFARYR SSQQKMEGQL QETRQQMTET SERLDRSLRQ 1200
DPGSSSVTRV PEKPFKGQEL AGRITPPPAD FQRPVFKTLL DQQADAARKA 1250
LSDEADLLNQ KVQTQLRQRD EQLSTAQNLW TDLVTRHKMS GGLDVTTPDA 1300
KALMEKPLET LRELLGKATQ QLPYLSAERT VRWMLAFLEE ALAQITADPT 1350
HPHHGSRTHY RNLQQQAVES AVTLAHQIEQ NAACENFIAQ HQEATANGAS 1400
TPRVDMVQAV EAVWQRLEPG RVAGGAARHQ KVQELLQRLG QTLGDLELQE 1450
TLATEYFALL HGIQTFSYGL DFRSQLEKIR DLRTRFAELA KRCGTRLSNE 1500
GALPNPRKPQ ATTSLGAFTR GLNALERHVQ LGHQYLLNKL NGSSLVYRLE 1550
DIPSVLPPTH ETDPALIMRD RLRRLCFARH HDTFLEVVDV FGMRQIVTQA 1600
GEPIYLVTDY GNVAFKYLAL RDDGRPLAWR RRCSGGGLKN VVTTRYKAIT 1650
VAVAVCQTLR TFWPQISQYD LRPYLTQHQS HTHPAETHTL HNLKLFCYLV 1700
STAWHQRIDT QQELTAADRV GSGEGGDVGE QRPGRGTVLR LSLQEFCVLI 1750
AALYPEYIYT VLKYPVQMSL PSLTAHLHQD VIHAVVNNTH KMPPDHLPEQ 1800
VKAFCITPTQ WPAMQLNKLF WENKLVQQLC QVGPQKSTPS LGKLWLYAMA 1850
TLVFPQDMLQ CLWLELKPQY AETYASVSEL VQTLFQIFTQ QCEMVTEGYT 1900
QPQLPTGEPV LQMIRVRRQD TTTTDTNTTT EPGLLDVFIQ TETALDYALG 1950
SWLFGIPVCL GVHVADLLKG QRVLVARHLE YTSRDRDFLR IQRSRDLNLS 2000
QLLQDTWTET PLEHCWLQAQ IRRLRDYLRF PTRLEFIPLV IYNAQDHTVV 2050
RVLRPPSTFE QDHSRLVLDE AFPTFPLYDQ DDNTSADNVA ASGAAPTPPV 2100
PFNRVPVNIQ FLRENPPPIA RVQQPPRRHR HRAAAAADDD GQIDHAQDDT 2150
SRTADSALVS TAFGGSVFQE NRLGETPLCR DELVAVAPGA ASTSFASPPI 2200
TVLTQNVLSA LEILRLVRLD LRQLAQSVQD TIQHMRFLYL L 2241
Length:2,241
Mass (Da):253,174
Last modified:July 5, 2004 - v1
Checksum:i83C76E6D72FA039B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY446894 Genomic DNA. Translation: AAR31613.1.
RefSeqiYP_081506.1. NC_006273.2.

Genome annotation databases

GeneIDi3077504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY446894 Genomic DNA. Translation: AAR31613.1 .
RefSeqi YP_081506.1. NC_006273.2.

3D structure databases

ProteinModelPortali Q6SW84.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3077504.

Family and domain databases

InterProi IPR006928. Pept_C76_UL36-USP.
[Graphical view ]
Pfami PF04843. Herpes_teg_N. 1 hit.
[Graphical view ]
PROSITEi PS51521. HTUSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDEN_HCMVM
AccessioniPrimary (citable) accession number: Q6SW84
Secondary accession number(s): D2K3L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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