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Q6SW84

- DEN_HCMVM

UniProt

Q6SW84 - DEN_HCMVM

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Protein

Deneddylase

Gene

UL48

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei24 – 241PROSITE-ProRule annotation
Active sitei160 – 1601PROSITE-ProRule annotation
Active sitei162 – 1621PROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
Alternative name(s):
Large tegument protein
Short name:
LTP
Gene namesi
Name:UL48
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000938: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. host cell nucleus Source: UniProtKB-KW
  3. viral tegument Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22412241DeneddylasePRO_0000416709Add
BLAST

Interactioni

Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6SW84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 226223Peptidase C76PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili544 – 57128Sequence AnalysisAdd
BLAST
Coiled coili765 – 79228Sequence AnalysisAdd
BLAST
Coiled coili1167 – 120034Sequence AnalysisAdd
BLAST
Coiled coili1240 – 127233Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi244 – 2474Poly-Thr
Compositional biasi325 – 3284Poly-Ser
Compositional biasi785 – 7895Poly-Glu
Compositional biasi1921 – 193010Poly-Thr
Compositional biasi2133 – 21375Poly-Ala

Sequence similaritiesi

Belongs to the herpesviridae deneddylase family.Curated
Contains 1 peptidase C76 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR006928. Pept_C76_UL36-USP.
[Graphical view]
PfamiPF04843. Herpes_teg_N. 1 hit.
[Graphical view]
PROSITEiPS51521. HTUSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6SW84-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVTQASCHQ GDIARFGARA GNQCVCNGIM FLHALHLGGT SAVLQTEALD
60 70 80 90 100
AIMEEGARLD ARLERELQKK LPAGGRLPVY RLGDEVPRRL ESRFGRTVHA
110 120 130 140 150
LSRPFNGTTE TCDLDGYMCP GIFDFLRYAH AKPRPTYVLV TVNSLARAVV
160 170 180 190 200
FTEDHMLVFD PHSSAECHNA AVYHCEGLHQ VLMVLTGFGV QLSPAFYYEA
210 220 230 240 250
LFLYMLDVAT VPEAEIAARL VSTYRDRDID LTGVVRESAD TAATTTTAAP
260 270 280 290 300
SLPPLPDPIV DPGCPPGVAP SIPVYDPSSS PKKTPEKRRK DLSGSKHGGK
310 320 330 340 350
KKPPSTTSKT LATASSSPSA IAAASSSSAV PPSYSCGEGA LPALGRYQQL
360 370 380 390 400
VDEVEQELKA LTLPPLPANT SAWTLHAAGT ESGANAATAT APSFDEAFLT
410 420 430 440 450
DRLQQLIIHA VNQRSCLRRP CGPQSAAQQA VRAYLGLSKK LDAFLLNWLH
460 470 480 490 500
HGLDLQRMHD YLSHKTTKGT YSTLDRALLE KMQVVFDPYG RQHGPALIAW
510 520 530 540 550
VEEMLRYVES KPTNELSQRL QRFVTKRPMP VSDSFVCLRP VDFQRLTQVI
560 570 580 590 600
EQRRRVLQRQ REEYHGVYEH LAGLITSIDI HDLDASDLNR REILKALQPL
610 620 630 640 650
DDNAKQELFR LGNAKMLELQ MDLDRLSTQL LTRVHNHILN GFLPVEDLKQ
660 670 680 690 700
MERVVEQVLR LFYDLRDLKL CDGSYEEGFV VIREQLSYLM TGTVRDNVPL
710 720 730 740 750
LQEILQLRHA YQQATQQNEG RLTQIHDLLH VIETLVRDPG SRGSALTLAL
760 770 780 790 800
VQEQLAQLEA LGGLQLPEVQ QRLQNAQLAL SRLYEEEEET QRFLDGLSYD
810 820 830 840 850
DPPTEQTIKR HPQLREMLRR DEQTRLRLIN AVLSMFHTLV MRLARDESPR
860 870 880 890 900
PTFFDAVSLL LQQLPPDSHE REDLRAANAT YAQMVKKLEQ IEKAGTGASE
910 920 930 940 950
KRFQALRELV YFFRNHEYFF QHMVGRLGVG PQVTELYERY QHEMEEQHLE
960 970 980 990 1000
RLEREWQEEA GKLTVTSVED VQRVLARAPS HRVMHQMQQT LTTKMQDFLD
1010 1020 1030 1040 1050
KEKRKQEEQQ RQLLDGYQKK VQQDLQRVVD AVKGEMLSTI PHQPLEATLE
1060 1070 1080 1090 1100
LLLGLDQRAQ PLLDKFNQDL LSALQQLSKK LDGRINECLH GVLTGDVERR
1110 1120 1130 1140 1150
CHPHREAAMQ TQASLNHLDQ ILGPQLLIHE TQQALQHAVH QAQFIEKCQQ
1160 1170 1180 1190 1200
GDPTTAITGS EFESDFARYR SSQQKMEGQL QETRQQMTET SERLDRSLRQ
1210 1220 1230 1240 1250
DPGSSSVTRV PEKPFKGQEL AGRITPPPAD FQRPVFKTLL DQQADAARKA
1260 1270 1280 1290 1300
LSDEADLLNQ KVQTQLRQRD EQLSTAQNLW TDLVTRHKMS GGLDVTTPDA
1310 1320 1330 1340 1350
KALMEKPLET LRELLGKATQ QLPYLSAERT VRWMLAFLEE ALAQITADPT
1360 1370 1380 1390 1400
HPHHGSRTHY RNLQQQAVES AVTLAHQIEQ NAACENFIAQ HQEATANGAS
1410 1420 1430 1440 1450
TPRVDMVQAV EAVWQRLEPG RVAGGAARHQ KVQELLQRLG QTLGDLELQE
1460 1470 1480 1490 1500
TLATEYFALL HGIQTFSYGL DFRSQLEKIR DLRTRFAELA KRCGTRLSNE
1510 1520 1530 1540 1550
GALPNPRKPQ ATTSLGAFTR GLNALERHVQ LGHQYLLNKL NGSSLVYRLE
1560 1570 1580 1590 1600
DIPSVLPPTH ETDPALIMRD RLRRLCFARH HDTFLEVVDV FGMRQIVTQA
1610 1620 1630 1640 1650
GEPIYLVTDY GNVAFKYLAL RDDGRPLAWR RRCSGGGLKN VVTTRYKAIT
1660 1670 1680 1690 1700
VAVAVCQTLR TFWPQISQYD LRPYLTQHQS HTHPAETHTL HNLKLFCYLV
1710 1720 1730 1740 1750
STAWHQRIDT QQELTAADRV GSGEGGDVGE QRPGRGTVLR LSLQEFCVLI
1760 1770 1780 1790 1800
AALYPEYIYT VLKYPVQMSL PSLTAHLHQD VIHAVVNNTH KMPPDHLPEQ
1810 1820 1830 1840 1850
VKAFCITPTQ WPAMQLNKLF WENKLVQQLC QVGPQKSTPS LGKLWLYAMA
1860 1870 1880 1890 1900
TLVFPQDMLQ CLWLELKPQY AETYASVSEL VQTLFQIFTQ QCEMVTEGYT
1910 1920 1930 1940 1950
QPQLPTGEPV LQMIRVRRQD TTTTDTNTTT EPGLLDVFIQ TETALDYALG
1960 1970 1980 1990 2000
SWLFGIPVCL GVHVADLLKG QRVLVARHLE YTSRDRDFLR IQRSRDLNLS
2010 2020 2030 2040 2050
QLLQDTWTET PLEHCWLQAQ IRRLRDYLRF PTRLEFIPLV IYNAQDHTVV
2060 2070 2080 2090 2100
RVLRPPSTFE QDHSRLVLDE AFPTFPLYDQ DDNTSADNVA ASGAAPTPPV
2110 2120 2130 2140 2150
PFNRVPVNIQ FLRENPPPIA RVQQPPRRHR HRAAAAADDD GQIDHAQDDT
2160 2170 2180 2190 2200
SRTADSALVS TAFGGSVFQE NRLGETPLCR DELVAVAPGA ASTSFASPPI
2210 2220 2230 2240
TVLTQNVLSA LEILRLVRLD LRQLAQSVQD TIQHMRFLYL L
Length:2,241
Mass (Da):253,174
Last modified:July 5, 2004 - v1
Checksum:i83C76E6D72FA039B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31613.1.
RefSeqiYP_081506.1. NC_006273.2.

Genome annotation databases

GeneIDi3077504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31613.1 .
RefSeqi YP_081506.1. NC_006273.2.

3D structure databases

ProteinModelPortali Q6SW84.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3077504.

Family and domain databases

InterProi IPR006928. Pept_C76_UL36-USP.
[Graphical view ]
Pfami PF04843. Herpes_teg_N. 1 hit.
[Graphical view ]
PROSITEi PS51521. HTUSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDEN_HCMVM
AccessioniPrimary (citable) accession number: Q6SW84
Secondary accession number(s): D2K3L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3