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Protein

mRNA export factor ICP27 homolog

Gene

UL69

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Immediate early (EI) protein that plays many roles during productive infection including regulation of host cell cycle progression, regulation of viral gene expression or nuclear export of intronless viral RNAs. Acts as a transcriptional transactivator via interaction with the cellular transcription elongation factor SUPT6H and as a nuclear RNA export factor via interaction with UAP56, a component of the cellular mRNA export machinery (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi387ZincBy similarity1
Metal bindingi494ZincBy similarity1
Metal bindingi496ZincBy similarity1
Metal bindingi501ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri387 – 501CHC2-typeBy similarityAdd BLAST115

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processG1/S host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Modulation of host cell cycle by virus, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor ICP27 homolog
Gene namesi
ORF Names:UL69
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004167111 – 742mRNA export factor ICP27 homologAdd BLAST742

Post-translational modificationi

Phosphorylated by UL97 and host CDK1, CDK7 and CD9. Phosphorylation by CDKs impacts on UL69 nuclear localization and activity (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Self-associates and forms high-molecular-mass complexes. Interacts with host DDX39A and DDX39B; these interactions are required for UL69 function in mRNA export. Interacts with host SUPT6H, EIF4A1 AND PABPC1 (By similarity).By similarity

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi202 – 205Poly-Gln4
Compositional biasi535 – 539Poly-Thr5
Compositional biasi595 – 598Poly-Ala4
Compositional biasi704 – 707Poly-Gln4
Compositional biasi708 – 715Poly-Pro8

Sequence similaritiesi

Belongs to the HHV-1 ICP27 protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri387 – 501CHC2-typeBy similarityAdd BLAST115

Keywords - Domaini

Zinc-finger

Phylogenomic databases

OrthoDBiVOG0900007Q.

Family and domain databases

InterProiView protein in InterPro
IPR008648. ICP27-like.
PfamiView protein in Pfam
PF05459. Herpes_UL69. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6SW73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELHSRGRHD APSLSSLSER ERRARRARRF CLDYEPVPRK FRRERSPTSP
60 70 80 90 100
STRNGAAASE YHLAEDTVGA ASHHHRPCVP ARRPRYSKDD DTEGDPDHYP
110 120 130 140 150
PPLPPSSRHA LGGTGGHIIM GTAGFRGGHR ASSSFKRRVA ASASVPLNPH
160 170 180 190 200
YGKSYDNDDG EPHHHGGDST HLRRRVPSCP TTFGSSHPSS ANNHHGSSAG
210 220 230 240 250
PQQQQMLALI DDELDAMDED ELQQLSRLIE KKKRARLQRG AASSGTSPSS
260 270 280 290 300
TSPVYDLQRY TAESLRLAPY PADLKVPTAF PQDHQPRGRI LLSHDELMHT
310 320 330 340 350
DYLLHIRQQF DWLEEPLLRK LVVEKIFAVY NAPNLHTLLA IIDETLSYMK
360 370 380 390 400
YHHLHGLPVN PHDPYLETVG GMRQLLFNKL NNLDLGCILD HQDGWGDHCS
410 420 430 440 450
TLKRLVKKPG QMSAWLRDDV CDLQKRPPET FSQPMHRAMA YVCSFSRVAV
460 470 480 490 500
SLRRRALQVT GTPQFFDQFD TNNAMGTYRC GAVSDLILGA LQCHECQNEM
510 520 530 540 550
CELRIQRALA PYRFMIAYCP FDEQSLLDLT VFAGTTTTTA SNHATAGGQQ
560 570 580 590 600
RGGDQIHPTD EQCASMESRT DPATLTAYDK KDREGSHRHP SPMIAAAAPP
610 620 630 640 650
AQPPSQPQQH YSEGELEEDE DSDDASSQDL VRATDRHGDT VVYKTTAVPP
660 670 680 690 700
SPPAPLAGVR SHRGELNLMT PSPSHGGSPP QVPHKQPIIP VQSANGNHST
710 720 730 740
TATQQQQPPP PPPVPQEDDS VVMRCQTPDY EDMLCYSDDM DD
Length:742
Mass (Da):82,397
Last modified:July 5, 2004 - v1
Checksum:iD6CF0E47B935A672
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31623.1.
RefSeqiYP_081517.1. NC_006273.2.

Genome annotation databases

GeneIDi3077554.
KEGGivg:3077554.

Similar proteinsi

Entry informationi

Entry nameiICP27_HCMVM
AccessioniPrimary (citable) accession number: Q6SW73
Secondary accession number(s): D2K3M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families