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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

UL72

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+By similarity

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:UL72
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000938 Componenti: Genome

Subcellular locationi

  1. Virion By similarity

GO - Cellular componenti

  1. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000416708Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

InterProiIPR029054. dUTPase-like.
IPR006882. Herpes_Orf11.
[Graphical view]
PfamiPF04797. Herpes_ORF11. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6SW70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTMLTDRID SQLVLSRLPR SRFQRFWETP TLIMKEESAP SSGSIILAEK
60 70 80 90 100
SVNMRYCVRF ASDSDFQTTF TLPQSTEEKY DKEQHPGEDE ASSPLPSPLK
110 120 130 140 150
VPYKWMPSSF IVKQCHTQLA FYNKHIIWLS RERKVPTSLG VSLYIPEGFF
160 170 180 190 200
GITFYKCLDA QFVCMPELLE SGLQVPQLDV VNLNDTFQSI FPGTIEGDIG
210 220 230 240 250
VFPCFVPEPW QLMNLPPPNE HRFFSLRTRQ TLVIGPGHTQ TVYFDAAYVH
260 270 280 290 300
APGICALIVG VRQFSQSDLI IRPTIWLPGT AAGVTVVNTS HTTVCISPHT
310 320 330 340 350
TVAKAVFTTH RFTYLPVGSH PLGQMIVPPT PDIGFTHTPE HALLQRTPSP
360 370 380
VDDDVDETEE DEKSSDAESP VNTSDVIFDV GPKPPRHP
Length:388
Mass (Da):43,459
Last modified:July 5, 2004 - v1
Checksum:i4B04A9E1909D9882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31625.1.
RefSeqiYP_081520.1. NC_006273.2.

Genome annotation databases

GeneIDi3077454.
KEGGivg:3077454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31625.1.
RefSeqiYP_081520.1. NC_006273.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3077454.
KEGGivg:3077454.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Family and domain databases

InterProiIPR029054. dUTPase-like.
IPR006882. Herpes_Orf11.
[Graphical view]
PfamiPF04797. Herpes_ORF11. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_HCMVM
AccessioniPrimary (citable) accession number: Q6SW70
Secondary accession number(s): D2K3M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.