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Q6SW70

- DUT_HCMVM

UniProt

Q6SW70 - DUT_HCMVM

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

UL72

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium.By similarity

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:UL72
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000938: Genome

Subcellular locationi

Virion By similarity

GO - Cellular componenti

  1. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000416708Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6SW70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

InterProiIPR029054. dUTPase-like.
IPR006882. Herpes_Orf11.
[Graphical view]
PfamiPF04797. Herpes_ORF11. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6SW70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTMLTDRID SQLVLSRLPR SRFQRFWETP TLIMKEESAP SSGSIILAEK
60 70 80 90 100
SVNMRYCVRF ASDSDFQTTF TLPQSTEEKY DKEQHPGEDE ASSPLPSPLK
110 120 130 140 150
VPYKWMPSSF IVKQCHTQLA FYNKHIIWLS RERKVPTSLG VSLYIPEGFF
160 170 180 190 200
GITFYKCLDA QFVCMPELLE SGLQVPQLDV VNLNDTFQSI FPGTIEGDIG
210 220 230 240 250
VFPCFVPEPW QLMNLPPPNE HRFFSLRTRQ TLVIGPGHTQ TVYFDAAYVH
260 270 280 290 300
APGICALIVG VRQFSQSDLI IRPTIWLPGT AAGVTVVNTS HTTVCISPHT
310 320 330 340 350
TVAKAVFTTH RFTYLPVGSH PLGQMIVPPT PDIGFTHTPE HALLQRTPSP
360 370 380
VDDDVDETEE DEKSSDAESP VNTSDVIFDV GPKPPRHP
Length:388
Mass (Da):43,459
Last modified:July 5, 2004 - v1
Checksum:i4B04A9E1909D9882
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY446894 Genomic DNA. Translation: AAR31625.1.
RefSeqiYP_081520.1. NC_006273.2.

Genome annotation databases

GeneIDi3077454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY446894 Genomic DNA. Translation: AAR31625.1 .
RefSeqi YP_081520.1. NC_006273.2.

3D structure databases

ProteinModelPortali Q6SW70.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3077454.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .

Family and domain databases

InterProi IPR029054. dUTPase-like.
IPR006882. Herpes_Orf11.
[Graphical view ]
Pfami PF04797. Herpes_ORF11. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_HCMVM
AccessioniPrimary (citable) accession number: Q6SW70
Secondary accession number(s): D2K3M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3