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Q6SW70 (DUT_HCMVM) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:UL72
OrganismHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) [Reference proteome]
Taxonomic identifier295027 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Subcellular location

Virion By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   Cellular componentVirion
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentvirion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000416708

Sequences

Sequence LengthMass (Da)Tools
Q6SW70 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4B04A9E1909D9882

FASTA38843,459
        10         20         30         40         50         60 
MLTMLTDRID SQLVLSRLPR SRFQRFWETP TLIMKEESAP SSGSIILAEK SVNMRYCVRF 

        70         80         90        100        110        120 
ASDSDFQTTF TLPQSTEEKY DKEQHPGEDE ASSPLPSPLK VPYKWMPSSF IVKQCHTQLA 

       130        140        150        160        170        180 
FYNKHIIWLS RERKVPTSLG VSLYIPEGFF GITFYKCLDA QFVCMPELLE SGLQVPQLDV 

       190        200        210        220        230        240 
VNLNDTFQSI FPGTIEGDIG VFPCFVPEPW QLMNLPPPNE HRFFSLRTRQ TLVIGPGHTQ 

       250        260        270        280        290        300 
TVYFDAAYVH APGICALIVG VRQFSQSDLI IRPTIWLPGT AAGVTVVNTS HTTVCISPHT 

       310        320        330        340        350        360 
TVAKAVFTTH RFTYLPVGSH PLGQMIVPPT PDIGFTHTPE HALLQRTPSP VDDDVDETEE 

       370        380 
DEKSSDAESP VNTSDVIFDV GPKPPRHP 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY446894 Genomic DNA. Translation: AAR31625.1.
RefSeqYP_081520.1. NC_006273.2.

3D structure databases

ProteinModelPortalQ6SW70.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3077454.

Phylogenomic databases

ProtClustDBPHA3128.

Enzyme and pathway databases

UniPathwayUPA00610; UER00666.

Family and domain databases

InterProIPR006882. Herpes_Orf11.
[Graphical view]
PfamPF04797. Herpes_ORF11. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_HCMVM
AccessionPrimary (citable) accession number: Q6SW70
Secondary accession number(s): D2K3M9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2004
Last modified: October 16, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways