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Protein

Envelope glycoprotein H

Gene

gH

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.UniRule annotation

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell
LigandSialic acid

Protein family/group databases

TCDBi1.G.22.1.1 the cytomegalovirus (human herpesvirus 5) glycoprotein go (go) family

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein HUniRule annotation
Short name:
gHUniRule annotation
Gene namesi
Name:gHUniRule annotation
Synonyms:UL75
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

  • Virion membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
  • Host cell membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
  • Host endosome membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
  • Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 719Virion surfaceUniRule annotationAdd BLAST696
Transmembranei720 – 740HelicalUniRule annotationAdd BLAST21
Topological domaini741 – 742IntravirionUniRule annotation2

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host endosome, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_000043665424 – 742Envelope glycoprotein HUniRule annotationAdd BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi62N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi67N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi192N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi641N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi700N-linked (GlcNAc...) asparagine; by hostUniRule annotation1

Post-translational modificationi

N-glycosylated, O-glycosylated, and sialylated.UniRule annotation

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6SW67

Interactioni

Subunit structurei

Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.UniRule annotation

Structurei

Secondary structure

1742
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi45 – 47Combined sources3
Beta strandi49 – 51Combined sources3
Beta strandi64 – 71Combined sources8
Beta strandi75 – 83Combined sources9
Beta strandi86 – 92Combined sources7
Helixi94 – 97Combined sources4
Helixi100 – 106Combined sources7
Helixi115 – 122Combined sources8
Helixi128 – 131Combined sources4
Turni147 – 150Combined sources4
Beta strandi152 – 155Combined sources4
Turni172 – 175Combined sources4
Beta strandi181 – 183Combined sources3
Beta strandi193 – 197Combined sources5
Turni198 – 200Combined sources3
Beta strandi202 – 205Combined sources4
Beta strandi207 – 217Combined sources11
Beta strandi219 – 222Combined sources4
Beta strandi224 – 241Combined sources18
Beta strandi246 – 251Combined sources6
Helixi264 – 267Combined sources4
Beta strandi268 – 271Combined sources4
Beta strandi276 – 280Combined sources5
Helixi285 – 287Combined sources3
Helixi290 – 292Combined sources3
Turni295 – 298Combined sources4
Helixi299 – 302Combined sources4
Helixi309 – 315Combined sources7
Helixi317 – 327Combined sources11
Helixi335 – 352Combined sources18
Helixi354 – 358Combined sources5
Helixi363 – 384Combined sources22
Helixi388 – 390Combined sources3
Helixi397 – 408Combined sources12
Beta strandi409 – 412Combined sources4
Helixi416 – 428Combined sources13
Helixi432 – 434Combined sources3
Helixi437 – 453Combined sources17
Helixi461 – 475Combined sources15
Helixi481 – 493Combined sources13
Helixi497 – 505Combined sources9
Beta strandi508 – 510Combined sources3
Helixi515 – 518Combined sources4
Helixi521 – 523Combined sources3
Beta strandi524 – 528Combined sources5
Helixi532 – 536Combined sources5
Helixi548 – 557Combined sources10
Turni567 – 571Combined sources5
Beta strandi576 – 581Combined sources6
Beta strandi584 – 594Combined sources11
Beta strandi597 – 603Combined sources7
Beta strandi614 – 619Combined sources6
Helixi645 – 647Combined sources3
Beta strandi650 – 661Combined sources12
Beta strandi663 – 669Combined sources7
Helixi672 – 679Combined sources8
Helixi682 – 684Combined sources3
Beta strandi692 – 697Combined sources6
Beta strandi703 – 705Combined sources3
Helixi707 – 710Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VOBX-ray3.02A1-715[»]
5VOCX-ray3.99A1-715[»]
5VODX-ray5.90A1-715[»]
SMRiQ6SW67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni217 – 280Interaction with gLUniRule annotationAdd BLAST64

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein H family.UniRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG0900004Y

Family and domain databases

Gene3Di2.60.40.3190, 1 hit
HAMAPiMF_04033 HSV_GH, 1 hit
InterProiView protein in InterPro
IPR003493 Herpes_gH
IPR035305 Herpes_glycoH_C
IPR038172 Herpes_glycoH_C_sf
PfamiView protein in Pfam
PF17488 Herpes_glycoH_C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6SW67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPGLPSYLI ILAVCLFSHL LSSRYGAEAV SEPLDKAFHL LLNTYGRPIR
60 70 80 90 100
FLRENTTQCT YNSSLRNSTV VRENAISFNF FQSYNQYYVF HMPRCLFAGP
110 120 130 140 150
LAEQFLNQVD LTETLERYQQ RLNTYALVSK DLASYRSFSQ QLKAQDSLGE
160 170 180 190 200
QPTTVPPPID LSIPHVWMPP QTTPHGWTES HTTSGLHRPH FNQTCILFDG
210 220 230 240 250
HDLLFSTVTP CLHQGFYLID ELRYVKITLT EDFFVVTVSI DDDTPMLLIF
260 270 280 290 300
GHLPRVLFKA PYQRDNFILR QTEKHELLVL VKKDQLNRHS YLKDPDFLDA
310 320 330 340 350
ALDFNYLDLS ALLRNSFHRY AVDVLKSGRC QMLDRRTVEM AFAYALALFA
360 370 380 390 400
AARQEEAGAQ VSVPRALDRQ AALLQIQEFM ITCLSQTPPR TTLLLYPTAV
410 420 430 440 450
DLAKRALWTP NQITDITSLV RLVYILSKQN QQHLIPQWAL RQIADFALKL
460 470 480 490 500
HKTHLASFLS AFARQELYLM GSLVHSMLVH TTERREIFIV ETGLCSLAEL
510 520 530 540 550
SHFTQLLAHP HHEYLSDLYT PCSSSGRRDH SLERLTRLFP DATVPATVPA
560 570 580 590 600
ALSILSTMQP STLETFPDLF CLPLGESFSA LTVSEHVSYI VTNQYLIKGI
610 620 630 640 650
SYPVSTTVVG QSLIITQTDS QTKCELTRNM HTTHSITVAL NISLENCAFC
660 670 680 690 700
QSALLEYDDT QGVINIMYMH DSDDVLFALD PYNEVVVSSP RTHYLMLLKN
710 720 730 740
GTVLEVTDVV VDATDSRLLM MSVYALSAII GIYLLYRMLK TC
Length:742
Mass (Da):84,321
Last modified:July 5, 2004 - v1
Checksum:iA4E837BA88DFF4DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31627.1
RefSeqiYP_081523.1, NC_006273.2

Genome annotation databases

GeneIDi3077450
KEGGivg:3077450

Similar proteinsi

Entry informationi

Entry nameiGH_HCMVM
AccessioniPrimary (citable) accession number: Q6SW67
Secondary accession number(s): D2K3N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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