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Protein

Capsid vertex component 2

Gene

CVC2

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.UniRule annotation

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral genome packaging, Viral penetration into host nucleus, Virus entry into host cell, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid vertex component 2UniRule annotation
Gene namesi
Name:CVC2UniRule annotation
Ordered Locus Names:UL77
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004183171 – 636Capsid vertex component 2Add BLAST636

Interactioni

Subunit structurei

Heterodimerizes with CVC1. Interacts with major capsid protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices. Interacts with the large tegument protein/LTP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6SW65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 48Interaction with major capsid protein/MCPUniRule annotationAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi434 – 437Poly-Leu4

Sequence similaritiesi

Belongs to the herpesviridae CVC2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900005N.

Family and domain databases

HAMAPiMF_04025. HSV_CVC2. 1 hit.
InterProiView protein in InterPro
IPR002493. Herpes_UL25.
PfamiView protein in Pfam
PF01499. Herpes_UL25. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6SW65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLHTFWRL PVAVFFEPHE ENVLRCPERV LRRLLEDAAV AMRGGGWRED
60 70 80 90 100
VLMDRVRKRY LRQELRDLGH RVQTYCEDLE GRVSEAEALL NQQCELDEGP
110 120 130 140 150
SPRTLLQPPC RPRSSSPGTG VAGASAVPHG LYSRHDAITG PVAAPSDAVA
160 170 180 190 200
ASAAAGASST WLAQCAEQPL PGNVPNYFGI TQNDPFIRFH TDFRGEVVNT
210 220 230 240 250
MFENASTWTF SFGIWYYRLK RGLYTQPRWK RVYHLAQMDN FSISQELLLG
260 270 280 290 300
VVNALENVTV YPTYDCVLSD LEAAACLLVA YGHALWEGRD PPDSVTAVLS
310 320 330 340 350
ELPQLLPRLA DDVSREIAAW EGPVAAGNNY YAYRDSPDLR YYMPLSGGRH
360 370 380 390 400
YHPGTFDRHV LVRLFHKRGV LQHLPGYGTI TEELVQERLS GQVRDDVLSL
410 420 430 440 450
WSRRLLVGKL GRDVPVFVHE QQYLRSGLTC LAGLLLLWKV TNADSVFAPR
460 470 480 490 500
TGKFTLADLL GSDAVAGGGL PGGRAGGEEK GYGGRHGRVR NFEFLVQYYI
510 520 530 540 550
GPWYARDPAV TLSQLFPGLA LLAVTESVRS GWDPSRREDS AGGGDGGGAV
560 570 580 590 600
LMQLSKSNPV ADYMFAQSSK QYGDLRRLEV HDALLFHYEH GLGRLLSVTL
610 620 630
PRHRVSTLGS SLFNVNDIYE LLYFLVLGFL PSVAVL
Length:636
Mass (Da):70,644
Last modified:July 5, 2004 - v1
Checksum:iD2C0A57D85F33CC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31629.1.
RefSeqiYP_081525.1. NC_006273.2.

Genome annotation databases

GeneIDi3077451.
KEGGivg:3077451.

Similar proteinsi

Entry informationi

Entry nameiCVC2_HCMVM
AccessioniPrimary (citable) accession number: Q6SW65
Secondary accession number(s): D2K3N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families