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Protein

Serine/threonine protein kinase UL97

Gene

UL97

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine protein kinase that plays important roles in several processes including nuclear viral egress, viral replication or regulation of host cell cycle progression. Participates in the acquisition of tegument during virion morphogenesis in the nucleus. Redistributes the host nuclear lamina by phosphorylating cellular Lamins-A/C. Plays a role in viral DNA synthesis by phosphorylating the DNA polymerase processivity factor UL44. Stimulates host cell cycle to support viral DNA synthesis by phosphorylating host retinoblastoma/RB1 protein. Additional substrates have been identified including host EF1D or H2B (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei456Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processHost-virus interaction, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine protein kinase UL97 (EC:2.7.1.-)
Gene namesi
Name:UL97
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004167071 – 707Serine/threonine protein kinase UL97Add BLAST707

Post-translational modificationi

Autophosphorylates on serine and threonine residues.By similarity

PTM databases

iPTMnetiQ6SW46.

Interactioni

Subunit structurei

Interacts with UL83.By similarity

Protein-protein interaction databases

BioGridi1678070. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ6SW46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi52 – 58Poly-Ala7

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG09000040.

Family and domain databases

InterProiView protein in InterPro
IPR010615. Herpes_UL97.
IPR011009. Kinase-like_dom.
IPR008266. Tyr_kinase_AS.
PfamiView protein in Pfam
PF06734. UL97. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6SW46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSALRSRAR SASLGTTTQG WDPPPLRRPS RARRRQWMRE AAQAAAQAAV
60 70 80 90 100
QAAQAAAAQV AQAHVDEDEV VDLMTDEAGG GVTTLTTLSS VSTTTVLGHA
110 120 130 140 150
TFSACVRSDV MRDGEKEDAA SDKENQRRPV VPSTSSRGSA ASGDGYHGLR
160 170 180 190 200
CRETSAMWSF EYDRDGDVTS VRRALFTGGS DPSDSVSGVR GGRKRPLRPP
210 220 230 240 250
LVSLARTPLC RRRVGGVDAV LEENDVELRA ESQDSAVASG PGRVPQPLSG
260 270 280 290 300
SSGEESATAV EADSTSHDDV HCTCSNDQII TTSIRGLTCD PRMFLRLTHP
310 320 330 340 350
ELCELSISYL LVYVPKEDDF CHKICYAVDM SDESYRLGQG SFGEVWPLDR
360 370 380 390 400
YRVVKVARKH SETVLTVWMS GLIRTRAAGE QQQPPSLVGT GVHRGLLTAT
410 420 430 440 450
GCCLLHNVTV HRRFHTDMFH HDQWKLACID SYRRAFCTLA DAIKFLNHQC
460 470 480 490 500
RVCHFDITPM NVLIDVNPHN PSEIVRAALC DYSLSEPYPD YNERCVAVFQ
510 520 530 540 550
ETGTARRIPN CSHRLRECYH PAFRPMPLQK LLICDPHARF PVAGLRRYCM
560 570 580 590 600
SELSALGNVL GFCLMRLLDR RGLDEVRMGT EALLFKHAGA ACRALENGKL
610 620 630 640 650
THCSDACLLI LAAQMSYGAC LLGEHGAALV SHTLRFVEAK MSSCRVRAFR
660 670 680 690 700
RFYHECSQTM LHEYVRKNVE RLLATSDGLY LYNAFRRTTS IICEEDLDGD

CRQLFPE
Length:707
Mass (Da):78,265
Last modified:July 5, 2004 - v1
Checksum:i6E036BF7F7A27094
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31648.1.
RefSeqiYP_081544.1. NC_006273.2.

Genome annotation databases

GeneIDi3077517.
KEGGivg:3077517.

Similar proteinsi

Entry informationi

Entry nameiUL97_HCMVM
AccessioniPrimary (citable) accession number: Q6SW46
Secondary accession number(s): D2K3Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2004
Last modified: February 15, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families