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Protein

Protein IRS1

Gene

IRS1

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts as a transactivator along with IE2, and is required for oriLyt-dependent DNA replication in the transient transfection replication assay using native promoters.

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host PKR by virus, Transcription, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein IRS1
Gene namesi
Name:IRS1
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004178311 – 847Protein IRS1Add BLAST847

Interactioni

Subunit structurei

Interacts (via N-terminus) with the viral DNA polymerase accessory subunit UL44. Interacts (via C-terminus) with host EIF2AK2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi426 – 438Poly-AlaAdd BLAST13
Compositional biasi612 – 615Poly-Pro4
Compositional biasi791 – 797Poly-Pro7

Sequence similaritiesi

Belongs to the herpesviridae US22 family.Curated

Phylogenomic databases

OrthoDBiVOG0900003V.

Family and domain databases

InterProiView protein in InterPro
IPR003360. US22-like.
PfamiView protein in Pfam
PF02393. US22. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform IRS1 (identifier: Q6SW04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQRNGMSPR PPPLGRGRGA GGPSGVGSSP PSSCVPMGAT STAGTGASAA
60 70 80 90 100
PTATPGHGVH RVEPRGPPGA PPSSGNNSNF WHGPERLLLS QIPVERQALT
110 120 130 140 150
ELEYQAMGAV WRAAFLANST GRAMRKWSQR DAGTLLPLGR PYGFYARVTP
160 170 180 190 200
RSQMNGVGAT DLRQLSPRDA WIVLVATVVH EVDPAADPTV GDKAGHPEGL
210 220 230 240 250
CAQDGLYLAL GAGFRVFVYD LANNTLILAA RDADEWFRHG AGEVVRLYRC
260 270 280 290 300
NRLGVGTPRA TLLPQPALRQ TLLRAEEATA LGRELRRRWA GTTVALQTPG
310 320 330 340 350
RRLQPMVLLG AWQELAQYEP FASAPHPASL LTAVRRHLNQ RLCCGWLALG
360 370 380 390 400
AVLPARWLGC AAGPATGTTS PPAASGTETE AAGGDAPCAM AGAVGSAVTI
410 420 430 440 450
PPQPYGGAGG SAICVPNADA HAVVGADATA AAAAAAAAPT VMVGPTAMAG
460 470 480 490 500
PAASGTVPRA MLVVVLDELG AVFGYCPLDG HVYPLAAELS HFLRAGVLGA
510 520 530 540 550
LALGRESAPA AEAARRLLPE LDREQWERPR WDALHLHPRA ALWAREPHGQ
560 570 580 590 600
WEFMFREQRG DPIHDPVAFR LSDARTLGLD LTTVMTERQS QLPEKYIGFY
610 620 630 640 650
QIRKPPWLME QPPPPSRQTK PDAATMPPPL SAQASVSYAL RYDDESWRPL
660 670 680 690 700
STVDDHKAWL DLDESHWVLG DSRPDDIKQR RLLKATQRRG AEIDRPMPVV
710 720 730 740 750
PEECYDQRFT TEGHQVIPLC ASEPEDDDED PTYDELPSRP PQKHKPPDKP
760 770 780 790 800
PRLCKTGPGP PPLPPKQRHG STDGKVSAPR QSEHHKRQTR PPRPPPPKFG
810 820 830 840
DRTAAHLSQN MRDMYLDMCT SSGHRPRPPA PPRPKKCQTH APHHVHH
Length:847
Mass (Da):91,190
Last modified:July 5, 2004 - v1
Checksum:i2B699C571D00C980
GO
Isoform IRS1-263 (identifier: Q6SW04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-584: Missing.

Show »
Length:263
Mass (Da):30,102
Checksum:iFCB346DC5B5F6B55
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0439211 – 584Missing in isoform IRS1-263. CuratedAdd BLAST584

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31691.1.
RefSeqiYP_081587.1. NC_006273.2.

Genome annotation databases

GeneIDi3077574.
KEGGivg:3077574.

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiIRS1_HCMVM
AccessioniPrimary (citable) accession number: Q6SW04
Secondary accession number(s): D2K3U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: July 5, 2004
Last modified: February 15, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families