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Protein

Unique short US6 glycoprotein

Gene

US6

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits peptide loading of MHC class I molecules by transporters associated with antigen processing (TAP). Does not prevent peptide binding to TAP, but binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1, but not TAP2. Also prevents the conformational rearrangement of TAP induced by peptide binding. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host adaptive immune response by virus, Inhibition of host TAP by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Unique short US6 glycoprotein
Gene namesi
Name:US6
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 143LumenalSequence analysisAdd BLAST124
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 182CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000041785220 – 182Unique short US6 glycoproteinAdd BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 126By similarity
Glycosylationi51N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed at early period of virus infection.

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with UL18.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 130Ig-like H-typeAdd BLAST101

Domaini

The ER-lumenal domain is responsible for TAP inhibition. It is sufficient to inhibit ATP binding to TAP (By similarity).By similarity

Sequence similaritiesi

Belongs to the cytomegalovirus US6 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000T1.

Family and domain databases

InterProiView protein in InterPro
IPR035129. US6.
PfamiView protein in Pfam
PF17616. US6. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD103071. PD103071. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6SW00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLIRLGFL LMCALPTPGE RSSRDPKTLL SLSPRQACVP RTKSHRPVCY
60 70 80 90 100
NDTGDCTDAD DSWKQLGEDF AHQCLQAAKK RPKTHKSRPN DRNLEGRLTC
110 120 130 140 150
QRVRRLLPCD LDIHPSHRLL TLMNNCVCDG AVWNAFRLIE RHGFFAVTLY
160 170 180
LCCGITLLVV ILALLCSITY ESTGRGIRRC GS
Length:182
Mass (Da):20,511
Last modified:July 5, 2004 - v1
Checksum:i4D0567C4F8C74AFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31695.1.
RefSeqiYP_081591.1. NC_006273.2.

Genome annotation databases

GeneIDi3077555.
KEGGivg:3077555.

Similar proteinsi

Entry informationi

Entry nameiUS06_HCMVM
AccessioniPrimary (citable) accession number: Q6SW00
Secondary accession number(s): D2K3V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families