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Protein

Protein TRS1

Gene

TRS1

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Inhibits the establishment of the antiviral state in the infected cell. Prevents the phosphorylation of the host eukaryotic translation initiation factor eIF-2alpha/EIF2S1 and thus the shutoff of viral and cellular protein synthesis by directly interacting with EIF2AK2/PKR. Also inhibits host autophagy by interacting with host Beclin-1/BECN1 (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host autophagy by virus, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host PKR by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TRS1
Gene namesi
Name:TRS1
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004182731 – 788Protein TRS1Add BLAST788

Interactioni

Subunit structurei

Interacts with host EIF2AK2/PKR; this interaction retains EIF2AK2 to the host nucleus and prevents its activation. Interaction (via N-terminus) with host BECN1; this interaction inhibits host autophagy. Interacts with the viral DNA polymerase accessory subunit UL44. Interacts with host HSPA5 (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae US22 family.Curated

Phylogenomic databases

OrthoDBiVOG0900004A.

Family and domain databases

InterProiView protein in InterPro
IPR003360. US22-like.
PfamiView protein in Pfam
PF02393. US22. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6SVX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRNGMSPR PPPLGRGRGA GGPSGVGSSP PSSCVPMGAT STAGTGASAA
60 70 80 90 100
PTATPGHGVH RVEPRGPPGA PPSSGNNSNF WHGPERLLLS QIPVERQALT
110 120 130 140 150
ELEYQAMGAV WRAAFLANST GRAMRKWSQR DAGTLLPLGR PYGFYARVTP
160 170 180 190 200
RSQMNGVGAT DLRQLSPRDA WIVLVATVVH EVDPAADPTV GDKAGHPEGL
210 220 230 240 250
CAQDGLYLAL GAGFRVFVYD LANNTLILAA RDADEWFRHG AGEVVRLYRC
260 270 280 290 300
NRLGVGTPRA TLLPQPALRQ TLLRAEEATA LGRELRRRWA GTTVALQTPG
310 320 330 340 350
RRLQPMVLLG AWQELAQYEP FASAPHPASL LTAVRRHLNQ RLCCGWLALG
360 370 380 390 400
AVLPARWLGC AAGPATGTTS PPAASGTETE AAGGDAPCAM AGAVGSAVTI
410 420 430 440 450
PPQPYGGAGG SAICVPNADA HAVVGADATA AAAAAAAAPT VMVGPTAMAG
460 470 480 490 500
PAASGTVPRA MLVVVLDELG AVFGYCPLDG HVYPLAAELS HFLRAGVLGA
510 520 530 540 550
LALGRESAPA AEAARRLLPE LDREQWERPR WDALHLHPRA ALWAREPHGQ
560 570 580 590 600
LAFLLRPGRG EAEVLTLATK HPVICANVED YLQDARRRAD AQALGLDLAT
610 620 630 640 650
VVMEAGGQMI HKKTKKPKGK EDESVMKGKH SRYTRPTEPP LTPQASLGRA
660 670 680 690 700
LRRDDEDWKP SRVPGEDSWY DLDETFWVLG SNRKNDVYQR RWKKTVLRCG
710 720 730 740 750
LEIDRPMPTV PKGCRPQTFT HEGIQLMGGA TQEPLDTGLY APSHVTSAFV
760 770 780
PSVYMPPTVP YPDPAARLCR DMRRVTFSNV ATHYHYNA
Length:788
Mass (Da):83,959
Last modified:July 5, 2004 - v1
Checksum:i79DACA06405652E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31723.1.
RefSeqiYP_081619.1. NC_006273.2.

Genome annotation databases

GeneIDi3077523.
KEGGivg:3077523.

Similar proteinsi

Entry informationi

Entry nameiTRS1_HCMVM
AccessioniPrimary (citable) accession number: Q6SVX2
Secondary accession number(s): D2K3Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 5, 2004
Last modified: February 15, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families