Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6STE5

- SMRD3_HUMAN

UniProt

Q6STE5 - SMRD3_HUMAN

Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

Gene

SMARCD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth By similarity.By similarity

    GO - Molecular functioni

    1. ligand-dependent nuclear receptor binding Source: BHF-UCL
    2. ligand-dependent nuclear receptor transcription coactivator activity Source: BHF-UCL
    3. nuclear hormone receptor binding Source: UniProtKB
    4. protein binding Source: IntAct
    5. receptor binding Source: UniProtKB
    6. transcription coactivator activity Source: BHF-UCL
    7. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. cardiac right ventricle formation Source: Ensembl
    2. cellular lipid metabolic process Source: Reactome
    3. chromatin remodeling Source: BHF-UCL
    4. muscle cell differentiation Source: Ensembl
    5. neural retina development Source: BHF-UCL
    6. nucleosome disassembly Source: BHF-UCL
    7. positive regulation of neuroblast proliferation Source: BHF-UCL
    8. positive regulation of transcription, DNA-templated Source: UniProtKB
    9. regulation of protein binding Source: Ensembl
    10. regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    11. secondary heart field specification Source: Ensembl
    12. small molecule metabolic process Source: Reactome
    13. transcription, DNA-templated Source: UniProtKB

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    Neurogenesis, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_116145. PPARA activates gene expression.
    REACT_118659. RORA activates circadian gene expression.
    REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_118789. REV-ERBA represses gene expression.
    REACT_147904. Activation of gene expression by SREBF (SREBP).
    REACT_19241. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
    REACT_200608. Transcriptional activation of mitochondrial biogenesis.
    REACT_24941. Circadian Clock.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
    Alternative name(s):
    60 kDa BRG-1/Brm-associated factor subunit C
    BRG1-associated factor 60C
    Short name:
    BAF60C
    Gene namesi
    Name:SMARCD3
    Synonyms:BAF60C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:11108. SMARCD3.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. nBAF complex Source: UniProtKB
    3. npBAF complex Source: UniProtKB
    4. nuclear chromatin Source: BHF-UCL
    5. nucleoplasm Source: Reactome
    6. nucleus Source: BHF-UCL
    7. SWI/SNF complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35958.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 483482SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3PRO_0000071988Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei178 – 1781Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ6STE5.
    PaxDbiQ6STE5.
    PRIDEiQ6STE5.

    PTM databases

    PhosphoSiteiQ6STE5.

    Expressioni

    Tissue specificityi

    Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue.

    Gene expression databases

    ArrayExpressiQ6STE5.
    BgeeiQ6STE5.
    CleanExiHS_SMARCD3.
    GenevestigatoriQ6STE5.

    Interactioni

    Subunit structurei

    Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Interacts with SMARCA4/BRG1/BAF190A, the catalytic subunit of the SWI/SNF related nucleosome-remodeling complexes BRG1(I) and BRG1(II). The precise distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins among these and other SWI/SNF nucleosome-remodeling complexes is not fully known. Also interacts with several nuclear receptors including PPARG/NR1C3, RXRA/NR1F1, ESR1, NR5A1, NR5A2/LRH1 and other transcriptional activators including the HLH protein SREBF1/SREBP1 and the homeobox protein PBX1. May allow recruitment of Swi/SNF containing complexes specifically to promoters where these factors are located. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPARGP372313EBI-488511,EBI-781384

    Protein-protein interaction databases

    BioGridi112488. 23 interactions.
    DIPiDIP-33012N.
    IntActiQ6STE5. 4 interactions.
    STRINGi9606.ENSP00000262188.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6STE5.
    SMRiQ6STE5. Positions 259-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini259 – 33476SWIBAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SMARCD family.Curated
    Contains 1 SWIB domain.Curated

    Phylogenomic databases

    eggNOGiCOG5531.
    HOVERGENiHBG054046.
    InParanoidiQ6STE5.
    KOiK11650.
    OMAiRAAFYHE.
    PhylomeDBiQ6STE5.
    TreeFamiTF106486.

    Family and domain databases

    Gene3Di1.10.245.10. 1 hit.
    InterProiIPR019835. SWIB_domain.
    IPR003121. SWIB_MDM2_domain.
    [Graphical view]
    PfamiPF02201. SWIB. 1 hit.
    [Graphical view]
    SMARTiSM00151. SWIB. 1 hit.
    [Graphical view]
    SUPFAMiSSF47592. SSF47592. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6STE5-1) [UniParc]FASTAAdd to Basket

    Also known as: BAF60C2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAADEVAGGA RKATKSKLFE FLVHGVRPGM PSGARMPHQG APMGPPGSPY    50
    MGSPAVRPGL APAGMEPARK RAAPPPGQSQ AQSQGQPVPT APARSRSAKR 100
    RKMADKILPQ RIRELVPESQ AYMDLLAFER KLDQTIMRKR VDIQEALKRP 150
    MKQKRKLRLY ISNTFNPAKP DAEDSDGSIA SWELRVEGKL LDDPSKQKRK 200
    FSSFFKSLVI ELDKDLYGPD NHLVEWHRTP TTQETDGFQV KRPGDLSVRC 250
    TLLLMLDYQP PQFKLDPRLA RLLGLHTQSR SAIVQALWQY VKTNRLQDSH 300
    DKEYINGDKY FQQIFDCPRL KFSEIPQRLT ALLLPPDPIV INHVISVDPS 350
    DQKKTACYDI DVEVEEPLKG QMSSFLLSTA NQQEISALDS KIHETIESIN 400
    QLKIQRDFML SFSRDPKGYV QDLLRSQSRD LKVMTDVAGN PEEERRAEFY 450
    HQPWSQEAVS RYFYCKIQQR RQELEQSLVV RNT 483
    Length:483
    Mass (Da):55,016
    Last modified:July 5, 2004 - v1
    Checksum:iB7B28DD11DCD0B5C
    GO
    Isoform 2 (identifier: Q6STE5-2) [UniParc]FASTAAdd to Basket

    Also known as: BAF60C1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-26: MAADEVAGGARKATKSKLFEFLVHGV → MTPGLQHPPTVVQ

    Show »
    Length:470
    Mass (Da):53,687
    Checksum:iDD6C2454B7AC2B04
    GO

    Sequence cautioni

    The sequence AAC50697.1 differs from that shown. Reason: Frameshift at positions 41, 65 and 78.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881V → E in AAC50697. (PubMed:8804307)Curated
    Sequence conflicti140 – 1401R → G in AAC50697. (PubMed:8804307)Curated
    Sequence conflicti387 – 3871A → P in AAC50697. (PubMed:8804307)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti170 – 1701P → S.1 Publication
    Corresponds to variant rs1050101 [ dbSNP | Ensembl ].
    VAR_020884

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2626MAADE…LVHGV → MTPGLQHPPTVVQ in isoform 2. 3 PublicationsVSP_012498Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66619 mRNA. Translation: AAC50697.1. Frameshift.
    AY450430 mRNA. Translation: AAR88510.1.
    AY450431 mRNA. Translation: AAR88511.1.
    AC021097 Genomic DNA. Translation: AAS00380.1.
    AC005486 Genomic DNA. Translation: AAS02031.1.
    CH471173 Genomic DNA. Translation: EAW54005.1.
    CH471173 Genomic DNA. Translation: EAW54007.1.
    CH471173 Genomic DNA. Translation: EAW54008.1.
    BC002628 mRNA. Translation: AAH02628.1.
    BC110350 mRNA. Translation: AAI10351.1.
    CCDSiCCDS34780.1. [Q6STE5-1]
    CCDS5924.1. [Q6STE5-2]
    RefSeqiNP_001003801.1. NM_001003801.1. [Q6STE5-1]
    NP_001003802.1. NM_001003802.1. [Q6STE5-2]
    NP_003069.2. NM_003078.3. [Q6STE5-2]
    UniGeneiHs.647067.

    Genome annotation databases

    EnsembliENST00000262188; ENSP00000262188; ENSG00000082014. [Q6STE5-1]
    ENST00000356800; ENSP00000349254; ENSG00000082014. [Q6STE5-2]
    ENST00000392811; ENSP00000376558; ENSG00000082014. [Q6STE5-2]
    GeneIDi6604.
    KEGGihsa:6604.
    UCSCiuc003wjs.3. human. [Q6STE5-1]
    uc003wjt.3. human. [Q6STE5-2]

    Polymorphism databases

    DMDMi57013057.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66619 mRNA. Translation: AAC50697.1 . Frameshift.
    AY450430 mRNA. Translation: AAR88510.1 .
    AY450431 mRNA. Translation: AAR88511.1 .
    AC021097 Genomic DNA. Translation: AAS00380.1 .
    AC005486 Genomic DNA. Translation: AAS02031.1 .
    CH471173 Genomic DNA. Translation: EAW54005.1 .
    CH471173 Genomic DNA. Translation: EAW54007.1 .
    CH471173 Genomic DNA. Translation: EAW54008.1 .
    BC002628 mRNA. Translation: AAH02628.1 .
    BC110350 mRNA. Translation: AAI10351.1 .
    CCDSi CCDS34780.1. [Q6STE5-1 ]
    CCDS5924.1. [Q6STE5-2 ]
    RefSeqi NP_001003801.1. NM_001003801.1. [Q6STE5-1 ]
    NP_001003802.1. NM_001003802.1. [Q6STE5-2 ]
    NP_003069.2. NM_003078.3. [Q6STE5-2 ]
    UniGenei Hs.647067.

    3D structure databases

    ProteinModelPortali Q6STE5.
    SMRi Q6STE5. Positions 259-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112488. 23 interactions.
    DIPi DIP-33012N.
    IntActi Q6STE5. 4 interactions.
    STRINGi 9606.ENSP00000262188.

    PTM databases

    PhosphoSitei Q6STE5.

    Polymorphism databases

    DMDMi 57013057.

    Proteomic databases

    MaxQBi Q6STE5.
    PaxDbi Q6STE5.
    PRIDEi Q6STE5.

    Protocols and materials databases

    DNASUi 6604.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262188 ; ENSP00000262188 ; ENSG00000082014 . [Q6STE5-1 ]
    ENST00000356800 ; ENSP00000349254 ; ENSG00000082014 . [Q6STE5-2 ]
    ENST00000392811 ; ENSP00000376558 ; ENSG00000082014 . [Q6STE5-2 ]
    GeneIDi 6604.
    KEGGi hsa:6604.
    UCSCi uc003wjs.3. human. [Q6STE5-1 ]
    uc003wjt.3. human. [Q6STE5-2 ]

    Organism-specific databases

    CTDi 6604.
    GeneCardsi GC07M150935.
    HGNCi HGNC:11108. SMARCD3.
    MIMi 601737. gene.
    neXtProti NX_Q6STE5.
    PharmGKBi PA35958.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5531.
    HOVERGENi HBG054046.
    InParanoidi Q6STE5.
    KOi K11650.
    OMAi RAAFYHE.
    PhylomeDBi Q6STE5.
    TreeFami TF106486.

    Enzyme and pathway databases

    Reactomei REACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_116145. PPARA activates gene expression.
    REACT_118659. RORA activates circadian gene expression.
    REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_118789. REV-ERBA represses gene expression.
    REACT_147904. Activation of gene expression by SREBF (SREBP).
    REACT_19241. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
    REACT_200608. Transcriptional activation of mitochondrial biogenesis.
    REACT_24941. Circadian Clock.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.

    Miscellaneous databases

    ChiTaRSi SMARCD3. human.
    GeneWikii SMARCD3.
    GenomeRNAii 6604.
    NextBioi 25695.
    PROi Q6STE5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6STE5.
    Bgeei Q6STE5.
    CleanExi HS_SMARCD3.
    Genevestigatori Q6STE5.

    Family and domain databases

    Gene3Di 1.10.245.10. 1 hit.
    InterProi IPR019835. SWIB_domain.
    IPR003121. SWIB_MDM2_domain.
    [Graphical view ]
    Pfami PF02201. SWIB. 1 hit.
    [Graphical view ]
    SMARTi SM00151. SWIB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47592. SSF47592. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Diversity and specialization of mammalian SWI/SNF complexes."
      Wang W., Xue Y., Zhou S., Kuo A., Cairns B.R., Crabtree G.R.
      Genes Dev. 10:2117-2130(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
    2. "Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit."
      Debril M.-B., Gelman L., Fayard E., Annicotte J.-S., Rocchi S., Auwerx J.
      J. Biol. Chem. 279:16677-16686(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, INTERACTION WITH SMARCA4 AND TRANSCRIPTIONAL ACTIVATORS, VARIANT SER-170.
      Tissue: Adipose tissue.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Blood and Uterus.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex."
      Lange M., Kaynak B., Forster U.B., Toenjes M., Fischer J.J., Grimm C., Schlesinger J., Just S., Dunkel I., Krueger T., Mebus S., Lehrach H., Lurz R., Gobom J., Rottbauer W., Abdelilah-Seyfried S., Sperling S.
      Genes Dev. 22:2370-2384(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE BAF COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSMRD3_HUMAN
    AccessioniPrimary (citable) accession number: Q6STE5
    Secondary accession number(s): D3DX10
    , Q2YD86, Q75MJ2, Q75MR8, Q92926, Q9BUH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3