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Protein

Protein S100-A10

Gene

S100a10

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.By similarity

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
S100 calcium-binding protein A10
p10 protein
Gene namesi
Name:S100a10
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002360221 – 97Protein S100-A10Add BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineBy similarity1
Modified residuei28N6-acetyllysineBy similarity1
Modified residuei37N6-acetyllysine; alternateBy similarity1
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei54N6-acetyllysineBy similarity1
Modified residuei57N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Expressioni

Gene expression databases

BgeeiENSOCUG00000005198.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000004503.

Structurei

3D structure databases

ProteinModelPortaliQ6SQH4.
SMRiQ6SQH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 71Ancestral calcium siteAdd BLAST12

Sequence similaritiesi

Belongs to the S-100 family.Curated

Phylogenomic databases

eggNOGiENOG410IXW9. Eukaryota.
ENOG410YSSI. LUCA.
GeneTreeiENSGT00760000119034.
HOVERGENiHBG001479.
InParanoidiQ6SQH4.
KOiK17274.
OMAiIACEQCY.
OrthoDBiEOG091G10QT.
TreeFamiTF332727.

Family and domain databases

CDDicd05024. S-100A10. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PANTHERiPTHR11639:SF90. PTHR11639:SF90. 1 hit.
PfamiView protein in Pfam
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6SQH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQMEHAME TMMFTFHKFA GDKGYLTKED LRVLMEKEFP GFLENQKDPL
60 70 80 90
AVDKIMKDLD QCRDGKVGFQ SFFSLIAGLT IACNDYFVVH MKQKGKK
Length:97
Mass (Da):11,203
Last modified:January 23, 2007 - v3
Checksum:i3E8E03A6E7DD7A8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY452731 mRNA. Translation: AAR17457.1.
RefSeqiNP_001075632.1. NM_001082163.1.
UniGeneiOcu.3102.

Genome annotation databases

EnsembliENSOCUT00000005196; ENSOCUP00000004503; ENSOCUG00000005198.
GeneIDi100008922.
KEGGiocu:100008922.

Similar proteinsi

Entry informationi

Entry nameiS10AA_RABIT
AccessioniPrimary (citable) accession number: Q6SQH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 94 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families