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Protein

Atherin

Gene

SAMD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in atherogenesis by immobilizing LDL in the atherial wall.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Atherin
Alternative name(s):
Sterile alpha motif domain-containing protein 1
Short name:
SAM domain-containing protein 1
Gene namesi
Name:SAMD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:17958. SAMD1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi90378.
PharmGKBiPA34937.

Polymorphism and mutation databases

BioMutaiSAMD1.
DMDMi74749329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794941 – 538AtherinAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107PhosphothreonineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei261PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6SPF0.
MaxQBiQ6SPF0.
PaxDbiQ6SPF0.
PeptideAtlasiQ6SPF0.
PRIDEiQ6SPF0.

PTM databases

iPTMnetiQ6SPF0.
PhosphoSitePlusiQ6SPF0.

Expressioni

Tissue specificityi

Expressed in atherosclerotic lesions, not in normal intima.1 Publication

Gene expression databases

CleanExiHS_SAMD1.

Organism-specific databases

HPAiHPA041662.
HPA049059.

Interactioni

Protein-protein interaction databases

BioGridi124704. 57 interactors.
IntActiQ6SPF0. 27 interactors.
MINTiMINT-4991013.
STRINGi9606.ENSP00000431971.

Structurei

3D structure databases

ProteinModelPortaliQ6SPF0.
SMRiQ6SPF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini462 – 530SAMPROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi101 – 235Pro-richAdd BLAST135
Compositional biasi327 – 332Poly-Glu6

Phylogenomic databases

eggNOGiENOG410IX26. Eukaryota.
ENOG4111QIZ. LUCA.
InParanoidiQ6SPF0.

Family and domain databases

InterProiView protein in InterPro
IPR001660. SAM.
IPR013761. SAM/pointed_sf.
PfamiView protein in Pfam
PF00536. SAM_1. 1 hit.
SMARTiView protein in SMART
SM00454. SAM. 1 hit.
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiView protein in PROSITE
PS50105. SAM_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6SPF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPPALPPP ETAAAATTAA AASSSAASPH YQEWILDTID SLRSRKARPD
60 70 80 90 100
LERICRMVRR RHGPEPERTR AELEKLIQQR AVLRVSYKGS ISYRNAARVQ
110 120 130 140 150
PPRRGATPPA PPRAPRGAPA AAAAAAPPPT PAPPPPPAPV AAAAPARAPR
160 170 180 190 200
AAAAAATAPP SPGPAQPGPR AQRAAPLAAP PPAPAAPPAV APPAGPRRAP
210 220 230 240 250
PPAVAAREPP LPPPPQPPAP PQQQQPPPPQ PQPPPEGGAV RAGGAARPVS
260 270 280 290 300
LREVVRYLGG SGGAGGRLTR GRVQGLLEEE AAARGRLERT RLGALALPRG
310 320 330 340 350
DRPGRAPPAA SARPSRSKRG GEERVLEKEE EEDDDEDEDE EDDVSEGSEV
360 370 380 390 400
PESDRPAGAQ HHQLNGERGP QSAKERVKEW TPCGPHQGQD EGRGPAPGSG
410 420 430 440 450
TRQVFSMAAM NKEGGTASVA TGPDSPSPVP LPPGKPALPG ADGTPFGCPP
460 470 480 490 500
GRKEKPSDPV EWTVMDVVEY FTEAGFPEQA TAFQEQEIDG KSLLLMQRTD
510 520 530
VLTGLSIRLG PALKIYEHHI KVLQQGHFED DDPDGFLG
Length:538
Mass (Da):56,052
Last modified:July 5, 2004 - v1
Checksum:i083A170790654F2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111 – 216Missing in AC022098 (PubMed:15057824).CuratedAdd BLAST106

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061701340E → D. Corresponds to variant dbSNP:rs8062Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY453840 mRNA. Translation: AAR24087.1.
AC022098 Genomic DNA. No translation available.
BC007384 mRNA. Translation: AAH07384.2.
BC030129 mRNA. Translation: AAH30129.1.
BC065477 mRNA. Translation: AAH65477.1.
BC080588 mRNA. Translation: AAH80588.1.
RefSeqiNP_612361.1. NM_138352.2.
UniGeneiHs.140309.

Genome annotation databases

GeneIDi90378.
KEGGihsa:90378.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSAMD1_HUMAN
AccessioniPrimary (citable) accession number: Q6SPF0
Secondary accession number(s): Q6P0R3, Q6PIS7, Q96IM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Due to its high GC content it turned out to be difficult to sequence the 5' end of the gene encoding the N-terminal proline-rich region of the protein and to unambiguously determine which sequence is correct. We display the sequence described in PubMed:16159594. This sequence fits better with orthologous sequences but is not consistent with the human reference genome sequence.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations