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Protein

Enkurin

Gene

Enkur

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Enkurin
Gene namesi
Name:Enkur
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1918483. Enkur.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: MGI
  • sperm principal piece Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869761 – 255EnkurinAdd BLAST255

Proteomic databases

MaxQBiQ6SP97.
PaxDbiQ6SP97.
PRIDEiQ6SP97.

PTM databases

PhosphoSitePlusiQ6SP97.

Expressioni

Tissue specificityi

High expression in testis and vomeronasal organ and lower expression in ovary, heart, lung, and brain. Not expressed in other tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000026679.
CleanExiMM_4933434I06RIK.
ExpressionAtlasiQ6SP97. baseline and differential.
GenevisibleiQ6SP97. MM.

Interactioni

Subunit structurei

Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027992.

Structurei

3D structure databases

ProteinModelPortaliQ6SP97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 252EnkurinPROSITE-ProRule annotationAdd BLAST93
Domaini176 – 187IQAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi83 – 89SH3-bindingSequence analysis7

Domaini

Residues 160-255 contains the TRPC2 binding site.
The IQ motif is involved in calmodulin binding.

Sequence similaritiesi

Contains 1 enkurin domain.PROSITE-ProRule annotation
Contains 1 IQ domain.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiENOG410IET1. Eukaryota.
ENOG410ZNA7. LUCA.
GeneTreeiENSGT00390000009461.
HOGENOMiHOG000007231.
HOVERGENiHBG056756.
InParanoidiQ6SP97.
OMAiTVKDDMQ.
OrthoDBiEOG091G0MPU.
PhylomeDBiQ6SP97.
TreeFamiTF323892.

Family and domain databases

InterProiIPR026150. Enkur.
IPR027012. Enkurin_dom.
[Graphical view]
PANTHERiPTHR21490:SF0. PTHR21490:SF0. 1 hit.
PfamiPF13864. Enkurin. 1 hit.
[Graphical view]
PROSITEiPS51665. ENKURIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6SP97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPCTSESI YNLIPSDLKE PPQHPRYTSL FRATIKNDMK KFKTAMKTMG
60 70 80 90 100
PAKVEIPSPK DFLKKHSKEK TLPPKKKFNR CSPKKPAVPL RTDHPVMGIQ
110 120 130 140 150
SGKNFINTNA ADVIMGVAKK PKPIYVDKRT GDKHDLETSG LFPKYINKKD
160 170 180 190 200
YGITPEYICK RNEDVKKAQE EYDNYIQENL KKAAMKRLSD EEREAVLQGL
210 220 230 240 250
KKNWEEVHKE FQSLSVFIDS VPKKIRKQKL EKEMKQLEHD ISVIEKHKII

YIANK
Length:255
Mass (Da):29,527
Last modified:July 5, 2004 - v1
Checksum:i325389264E2701EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY454124 mRNA. Translation: AAS45167.1.
CCDSiCCDS38055.1.
RefSeqiNP_082004.1. NM_027728.2.
UniGeneiMm.27658.

Genome annotation databases

EnsembliENSMUST00000027992; ENSMUSP00000027992; ENSMUSG00000026679.
GeneIDi71233.
KEGGimmu:71233.
UCSCiuc008ina.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY454124 mRNA. Translation: AAS45167.1.
CCDSiCCDS38055.1.
RefSeqiNP_082004.1. NM_027728.2.
UniGeneiMm.27658.

3D structure databases

ProteinModelPortaliQ6SP97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027992.

PTM databases

PhosphoSitePlusiQ6SP97.

Proteomic databases

MaxQBiQ6SP97.
PaxDbiQ6SP97.
PRIDEiQ6SP97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027992; ENSMUSP00000027992; ENSMUSG00000026679.
GeneIDi71233.
KEGGimmu:71233.
UCSCiuc008ina.1. mouse.

Organism-specific databases

CTDi219670.
MGIiMGI:1918483. Enkur.

Phylogenomic databases

eggNOGiENOG410IET1. Eukaryota.
ENOG410ZNA7. LUCA.
GeneTreeiENSGT00390000009461.
HOGENOMiHOG000007231.
HOVERGENiHBG056756.
InParanoidiQ6SP97.
OMAiTVKDDMQ.
OrthoDBiEOG091G0MPU.
PhylomeDBiQ6SP97.
TreeFamiTF323892.

Miscellaneous databases

PROiQ6SP97.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026679.
CleanExiMM_4933434I06RIK.
ExpressionAtlasiQ6SP97. baseline and differential.
GenevisibleiQ6SP97. MM.

Family and domain databases

InterProiIPR026150. Enkur.
IPR027012. Enkurin_dom.
[Graphical view]
PANTHERiPTHR21490:SF0. PTHR21490:SF0. 1 hit.
PfamiPF13864. Enkurin. 1 hit.
[Graphical view]
PROSITEiPS51665. ENKURIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENKUR_MOUSE
AccessioniPrimary (citable) accession number: Q6SP97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.