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Protein

Sarcolipin

Gene

Sln

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcolipin
Gene namesi
Name:Sln
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1305224. Sln.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicBy similarity
Transmembranei8 – 2619HelicalBy similarityAdd
BLAST
Topological domaini27 – 315LumenalBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3131SarcolipinPRO_0000045901Add
BLAST

Proteomic databases

PaxDbiQ6SLE7.

PTM databases

iPTMnetiQ6SLE7.
PhosphoSiteiQ6SLE7.

Expressioni

Gene expression databases

GenevisibleiQ6SLE7. RN.

Interactioni

Subunit structurei

Interacts with calcium ATPase ATP2A1/SERCA1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011970.

Structurei

3D structure databases

ProteinModelPortaliQ6SLE7.
SMRiQ6SLE7. Positions 1-31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sarcolipin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JIZ8. Eukaryota.
ENOG411147S. LUCA.
GeneTreeiENSGT00530000064724.
HOGENOMiHOG000142457.
HOVERGENiHBG079165.
InParanoidiQ6SLE7.
OrthoDBiEOG7T7GXN.
PhylomeDBiQ6SLE7.

Family and domain databases

InterProiIPR008028. Sarcolipin.
[Graphical view]
PfamiPF05366. Sarcolipin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6SLE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MERSTQELFI NFTVVLITVL LMWLLVRSYQ Y
Length:31
Mass (Da):3,808
Last modified:July 5, 2004 - v1
Checksum:i9B310161575EF81D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY456000 mRNA. Translation: AAR19044.1.
RefSeqiNP_001013265.1. NM_001013247.1.
UniGeneiRn.16457.

Genome annotation databases

EnsembliENSRNOT00000011974; ENSRNOP00000011970; ENSRNOG00000009047.
GeneIDi367086.
KEGGirno:367086.
UCSCiRGD:1305224. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY456000 mRNA. Translation: AAR19044.1.
RefSeqiNP_001013265.1. NM_001013247.1.
UniGeneiRn.16457.

3D structure databases

ProteinModelPortaliQ6SLE7.
SMRiQ6SLE7. Positions 1-31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011970.

PTM databases

iPTMnetiQ6SLE7.
PhosphoSiteiQ6SLE7.

Proteomic databases

PaxDbiQ6SLE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011974; ENSRNOP00000011970; ENSRNOG00000009047.
GeneIDi367086.
KEGGirno:367086.
UCSCiRGD:1305224. rat.

Organism-specific databases

CTDi6588.
RGDi1305224. Sln.

Phylogenomic databases

eggNOGiENOG410JIZ8. Eukaryota.
ENOG411147S. LUCA.
GeneTreeiENSGT00530000064724.
HOGENOMiHOG000142457.
HOVERGENiHBG079165.
InParanoidiQ6SLE7.
OrthoDBiEOG7T7GXN.
PhylomeDBiQ6SLE7.

Miscellaneous databases

PROiQ6SLE7.

Gene expression databases

GenevisibleiQ6SLE7. RN.

Family and domain databases

InterProiIPR008028. Sarcolipin.
[Graphical view]
PfamiPF05366. Sarcolipin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Minamisawa S., Yokoyama U., Sato Y., Nakagome M., Mouri M., Uemura N., Hori H., Ishikawa Y.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Heart atrium.

Entry informationi

Entry nameiSARCO_RAT
AccessioniPrimary (citable) accession number: Q6SLE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.