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Protein
Submitted name:

M2 muscarinic acetylcholine receptor

Gene

CHRM2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
M2 muscarinic acetylcholine receptorImported
Gene namesi
Name:CHRM2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA111.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319984.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4646G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
KOiK04130.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001065. Musac_Ach_M2_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PANTHERiPTHR24249:SF57. PTHR24249:SF57. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00243. MUSCARINICR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6SL56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AFIITWAPYN VMVLINTFCA PCIPNTVWTI GYWLCYINST INPACYALCN
60 70
ATFKKTFKHL LMCHYKNIGA TR
Length:72
Mass (Da):8,269
Last modified:July 5, 2004 - v1
Checksum:i8A833B2696817373
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY456128 mRNA. Translation: AAR14893.1.
AY456129 mRNA. Translation: AAR14894.1.
RefSeqiNP_000730.1. NM_000739.2.
NP_001006627.1. NM_001006626.1.
NP_001006628.1. NM_001006627.1.
NP_001006629.1. NM_001006628.1.
NP_001006630.1. NM_001006629.1.
NP_001006631.1. NM_001006630.1.
NP_001006632.1. NM_001006631.1.
NP_001006633.1. NM_001006632.1.
UniGeneiHs.535891.

Genome annotation databases

GeneIDi1129.
KEGGihsa:1129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY456128 mRNA. Translation: AAR14893.1.
AY456129 mRNA. Translation: AAR14894.1.
RefSeqiNP_000730.1. NM_000739.2.
NP_001006627.1. NM_001006626.1.
NP_001006628.1. NM_001006627.1.
NP_001006629.1. NM_001006628.1.
NP_001006630.1. NM_001006629.1.
NP_001006631.1. NM_001006630.1.
NP_001006632.1. NM_001006631.1.
NP_001006633.1. NM_001006632.1.
UniGeneiHs.535891.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319984.

Protocols and materials databases

DNASUi1129.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1129.
KEGGihsa:1129.

Organism-specific databases

CTDi1129.
PharmGKBiPA111.

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
KOiK04130.

Miscellaneous databases

ChiTaRSiCHRM2. human.
GenomeRNAii1129.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001065. Musac_Ach_M2_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PANTHERiPTHR24249:SF57. PTHR24249:SF57. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00243. MUSCARINICR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Multiple promoters drive tissue-specific expression of the human M muscarinic acetylcholine receptor gene."
    Krejci A., Bruce A.W., Dolezal V., Tucek S., Buckley N.J.
    J. Neurochem. 91:88-98(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6SL56_HUMAN
AccessioniPrimary (citable) accession number: Q6SL56
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.