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Protein

Acyl-coenzyme A synthetase ACSM3, mitochondrial

Gene

Acsm3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C4 to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).By similarity

Catalytic activityi

ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei455 – 4551ATPBy similarity
Binding sitei470 – 4701ATPBy similarity
Binding sitei566 – 5661ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi229 – 2379ATPBy similarity
Nucleotide bindingi368 – 3736ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A synthetase ACSM3, mitochondrial (EC:6.2.1.2)
Alternative name(s):
Acyl-CoA synthetase medium-chain family member 3
Butyrate--CoA ligase 3
Butyryl-coenzyme A synthetase 3
Middle-chain acyl-CoA synthetase 3
SA rat hypertension-associated protein
Short name:
Protein SA
Gene namesi
Name:Acsm3
Synonyms:Sah
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi62086. Acsm3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionSequence analysisAdd
BLAST
Chaini22 – 580559Acyl-coenzyme A synthetase ACSM3, mitochondrialPRO_0000306100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671N6-succinyllysineBy similarity
Modified residuei100 – 1001N6-succinyllysineBy similarity
Modified residuei151 – 1511N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6SKG1.
PRIDEiQ6SKG1.

PTM databases

iPTMnetiQ6SKG1.

Expressioni

Gene expression databases

GenevisibleiQ6SKG1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020039.

Structurei

3D structure databases

ProteinModelPortaliQ6SKG1.
SMRiQ6SKG1. Positions 46-578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229982.
HOVERGENiHBG053031.
InParanoidiQ6SKG1.
KOiK01896.
OMAiAIPKAYV.
OrthoDBiEOG7D85VZ.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6SKG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMLLRARCF HRLAIPDPRR ILYKDYRTAI PQNFSNYESM KHDFKIEIPE
60 70 80 90 100
YFNFAKDVLD QWTNTEKTGK RLSNPAFWWV DGNGKEVRWS FEELGSLSRK
110 120 130 140 150
FANILTEACS LQRGDRVMVI LPKIPEWWLA NVACLRTGTV LIPGTTQLTQ
160 170 180 190 200
KDILYRLQSS KSKCIITDDT LAPAVDIVAA KCENLHSKLI VSQHSREGWG
210 220 230 240 250
NLKEMMKYAS DSHTCVDTKH NELMAIYFTS GTTGPPKMIG HTHSSFGLGL
260 270 280 290 300
SVNGRFWLDL IASDVMWNTS DTGWAKSAWS SVFSPWTQGA CVFAHYLPRF
310 320 330 340 350
DSTSILQTLS KFPITVFCSA PTAYRMLIQN DITSYKFNSL KHCVSAGEPI
360 370 380 390 400
NPEVMEQWKK KTGLDIYEGY GQTETVLICG NFKGMKIKPG SMGKPSPAFN
410 420 430 440 450
VEILDENGTI LPPGQEGDIA VQVLPDRPFG LFTHYVDNPS KTASTLRGNF
460 470 480 490 500
YITGDRGYMD EDGYFWFVAR SDDVILSSGY RIGPFEVESA LIEHPSIAES
510 520 530 540 550
AVVSSPDPIR GEVVKAFIVL NPDYKLHDQE QLKKEIQEHV KKTTAPYKYP
560 570 580
RKIEFIEELP KTVSGKVKRN ELRRKEWTTT
Length:580
Mass (Da):65,713
Last modified:July 5, 2004 - v1
Checksum:iE2F46C5C530D6278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY455861 Genomic DNA. Translation: AAR20710.1.
AY456695 Genomic DNA. Translation: AAR21570.1.
BC090325 mRNA. Translation: AAH90325.1.
U19832 Genomic DNA. Translation: AAA95995.1.
RefSeqiNP_150234.1. NM_033231.1.
UniGeneiRn.88644.

Genome annotation databases

EnsembliENSRNOT00000020039; ENSRNOP00000020039; ENSRNOG00000032246.
GeneIDi24763.
KEGGirno:24763.
UCSCiRGD:62086. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY455861 Genomic DNA. Translation: AAR20710.1.
AY456695 Genomic DNA. Translation: AAR21570.1.
BC090325 mRNA. Translation: AAH90325.1.
U19832 Genomic DNA. Translation: AAA95995.1.
RefSeqiNP_150234.1. NM_033231.1.
UniGeneiRn.88644.

3D structure databases

ProteinModelPortaliQ6SKG1.
SMRiQ6SKG1. Positions 46-578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020039.

PTM databases

iPTMnetiQ6SKG1.

Proteomic databases

PaxDbiQ6SKG1.
PRIDEiQ6SKG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020039; ENSRNOP00000020039; ENSRNOG00000032246.
GeneIDi24763.
KEGGirno:24763.
UCSCiRGD:62086. rat.

Organism-specific databases

CTDi6296.
RGDi62086. Acsm3.

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229982.
HOVERGENiHBG053031.
InParanoidiQ6SKG1.
KOiK01896.
OMAiAIPKAYV.
OrthoDBiEOG7D85VZ.

Miscellaneous databases

NextBioi604315.
PROiQ6SKG1.

Gene expression databases

GenevisibleiQ6SKG1. RN.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Exon repetition: a major pathway for processing mRNA of some genes is allele-specific."
    Rigatti R., Jia J.-H., Samani N.J., Eperon I.C.
    Nucleic Acids Res. 32:441-446(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SHR and Wistar Kyoto.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Possible alternative splicing of the rat SA gene."
    Gu L., Dene H., Rapp J.P.
    Mamm. Genome 6:683-684(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 374-479.

Entry informationi

Entry nameiACSM3_RAT
AccessioniPrimary (citable) accession number: Q6SKG1
Secondary accession number(s): Q62742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: January 20, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.