ID   TBPL2_HUMAN             Reviewed;         375 AA.
AC   Q6SJ96; Q17RU8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   24-NOV-2009, entry version 48.
DE   RecName: Full=TATA box-binding protein-like protein 2;
DE            Short=TBP-like protein 2;
DE   AltName: Full=TATA box-binding protein-related factor 3;
DE            Short=TBP-related factor 3;
GN   Name=TBPL2; Synonyms=TBP2, TRF3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=14634207; DOI=10.1073/pnas.2036440100;
RA   Persengiev S.P., Zhu X., Dixit B.L., Maston G.A., Kittler E.L.W.,
RA   Green M.R.;
RT   "TRF3, a TATA-box-binding protein-related factor, is vertebrate-
RT   specific and widely expressed.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:14887-14891(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=17570761; DOI=10.1089/dna.2006.0527;
RA   Di Pietro C., Ragusa M., Duro L., Guglielmino M.R., Barbagallo D.,
RA   Carnemolla A., Lagana A., Buffa P., Angelica R., Rinaldi A.,
RA   Calafato M.S., Milicia I., Caserta C., Giugno R., Pulvirenti A.,
RA   Giunta V., Rapisarda A., Di Pietro V., Grillo A., Messina A.,
RA   Ferro A., Grzeschik K.H., Purrello M.;
RT   "Genomics, evolution, and expression of TBPL2, a member of the TBP
RT   family.";
RL   DNA Cell Biol. 26:369-385(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-31.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcription factor required in complex with TAF3 for
CC       the differentiation of myoblasts into myocytes. The complex
CC       replaces TFIID at specific promoters at an early stage in the
CC       differentiation process (By similarity).
CC   -!- SUBUNIT: Interacts with TAF3 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Present in the
CC       cytoplasm during cytokenesis.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed in all tissues examined
CC       with highest levels in heart, lung, ovary, spleen and testes.
CC   -!- SIMILARITY: Belongs to the TBP family.
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DR   EMBL; AY457923; AAR24281.1; -; mRNA.
DR   EMBL; DQ448593; ABD93323.1; -; mRNA.
DR   EMBL; BC117159; AAI17160.1; -; mRNA.
DR   EMBL; BC117185; AAI17186.1; -; mRNA.
DR   IPI; IPI00791135; -.
DR   RefSeq; NP_950248.1; -.
DR   UniGene; Hs.528278; -.
DR   HSSP; P20226; 1CDW.
DR   SMR; Q6SJ96; 197-374.
DR   STRING; Q6SJ96; -.
DR   PRIDE; Q6SJ96; -.
DR   Ensembl; ENST00000247219; ENSP00000247219; ENSG00000182521; Homo sapiens.
DR   GeneID; 387332; -.
DR   KEGG; hsa:387332; -.
DR   NMPDR; fig|9606.3.peg.9635; -.
DR   UCSC; uc001xby.1; human.
DR   CTD; 387332; -.
DR   GeneCards; GC14M054950; -.
DR   HGNC; HGNC:19841; TBPL2.
DR   MIM; 608964; gene.
DR   HOVERGEN; Q6SJ96; -.
DR   OMA; LYLDQCA; -.
DR   OrthoDB; EOG9K0T76; -.
DR   NextBio; 101297; -.
DR   ArrayExpress; Q6SJ96; -.
DR   CleanEx; HS_TBPL2; -.
DR   Genevestigator; Q6SJ96; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003702; F:RNA polymerase II transcription factor acti...; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR   GO; GO:0006367; P:transcription initiation from RNA polymeras...; IEA:InterPro.
DR   InterPro; IPR012295; b_Adaptin_TBP_C.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR012294; TFIID_C/glycos_N.
DR   Gene3D; G3DSA:3.30.310.10; b_Adaptin_TBP_C; 2.
DR   PANTHER; PTHR10126; TBP; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytoplasm; Developmental protein; DNA-binding;
KW   Nucleus; Polymorphism; Transcription; Transcription regulation.
FT   CHAIN         1    375       TATA box-binding protein-like protein 2.
FT                                /FTId=PRO_0000318118.
FT   COMPBIAS     22     26       Poly-Pro.
FT   VARIANT      31     31       R -> P (in dbSNP:rs8019270).
FT                                /FTId=VAR_038692.
SQ   SEQUENCE   375 AA;  41524 MW;  E55539A49FE76704 CRC64;
     MASAPWPERV PRLLAPRLPS YPPPPPTVGL RSMEQEETYL ELYLDQCAAQ DGLAPPRSPL
     FSPVVPYDMY ILNASNPDTA FNSNPEVKET SGDFSSVDLS FLPDEVTQEN KDQPVISKHE
     TEENSESQSP QSRLPSPSEQ DVGLGLNSSS LSNSHSQLHP GDTDSVQPSP EKPNSDSLSL
     ASITPMTPMT PISECCGIVP QLQNIVSTVN LACKLDLKKI ALHAKNAEYN PKRFAAVIMR
     IREPRTTALI FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPARFLDF KIQNMVGSCD
     VRFPIRLEGL VLTHQQFSSY EPELFPGLIY RMVKPRIVLL IFVSGKVVLT GAKERSEIYE
     AFENIYPILK GFKKA
//