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Protein

TATA box-binding protein-like protein 2

Gene

TBPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-like protein 2
Short name:
TBP-like protein 2
Alternative name(s):
TATA box-binding protein-related factor 3
Short name:
TBP-related factor 3
Gene namesi
Name:TBPL2Imported
Synonyms:TBP2, TRF3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19841. TBPL2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134990291.

Polymorphism and mutation databases

BioMutaiTBPL2.
DMDMi74749326.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375TATA box-binding protein-like protein 2PRO_0000318118Add
BLAST

Proteomic databases

EPDiQ6SJ96.
PaxDbiQ6SJ96.
PRIDEiQ6SJ96.

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined with highest levels in heart, lung, ovary, spleen and testes.2 Publications

Gene expression databases

CleanExiHS_TBPL2.
ExpressionAtlasiQ6SJ96. baseline and differential.

Organism-specific databases

HPAiHPA056241.

Interactioni

Subunit structurei

Interacts with TAF3.By similarity

Protein-protein interaction databases

BioGridi132286. 8 interactions.
STRINGi9606.ENSP00000247219.

Structurei

3D structure databases

ProteinModelPortaliQ6SJ96.
SMRiQ6SJ96. Positions 197-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 265Poly-ProSequence analysis

Sequence similaritiesi

Belongs to the TBP family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3302. Eukaryota.
COG2101. LUCA.
GeneTreeiENSGT00410000025389.
HOGENOMiHOG000105164.
HOVERGENiHBG044997.
InParanoidiQ6SJ96.
KOiK03120.
OMAiECCGIVP.
OrthoDBiEOG7XWPPF.
PhylomeDBiQ6SJ96.
TreeFamiTF300102.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6SJ96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAPWPERV PRLLAPRLPS YPPPPPTVGL RSMEQEETYL ELYLDQCAAQ
60 70 80 90 100
DGLAPPRSPL FSPVVPYDMY ILNASNPDTA FNSNPEVKET SGDFSSVDLS
110 120 130 140 150
FLPDEVTQEN KDQPVISKHE TEENSESQSP QSRLPSPSEQ DVGLGLNSSS
160 170 180 190 200
LSNSHSQLHP GDTDSVQPSP EKPNSDSLSL ASITPMTPMT PISECCGIVP
210 220 230 240 250
QLQNIVSTVN LACKLDLKKI ALHAKNAEYN PKRFAAVIMR IREPRTTALI
260 270 280 290 300
FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPARFLDF KIQNMVGSCD
310 320 330 340 350
VRFPIRLEGL VLTHQQFSSY EPELFPGLIY RMVKPRIVLL IFVSGKVVLT
360 370
GAKERSEIYE AFENIYPILK GFKKA
Length:375
Mass (Da):41,524
Last modified:July 5, 2004 - v1
Checksum:iE55539A49FE76704
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311R → P.1 Publication
Corresponds to variant rs8019270 [ dbSNP | Ensembl ].
VAR_038692

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY457923 mRNA. Translation: AAR24281.1.
DQ448593 mRNA. Translation: ABD93323.1.
BC117159 mRNA. Translation: AAI17160.1.
BC117185 mRNA. Translation: AAI17186.1.
CCDSiCCDS9724.1.
RefSeqiNP_950248.1. NM_199047.2.
UniGeneiHs.528278.

Genome annotation databases

EnsembliENST00000247219; ENSP00000247219; ENSG00000182521.
GeneIDi387332.
KEGGihsa:387332.
UCSCiuc001xby.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY457923 mRNA. Translation: AAR24281.1.
DQ448593 mRNA. Translation: ABD93323.1.
BC117159 mRNA. Translation: AAI17160.1.
BC117185 mRNA. Translation: AAI17186.1.
CCDSiCCDS9724.1.
RefSeqiNP_950248.1. NM_199047.2.
UniGeneiHs.528278.

3D structure databases

ProteinModelPortaliQ6SJ96.
SMRiQ6SJ96. Positions 197-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132286. 8 interactions.
STRINGi9606.ENSP00000247219.

Polymorphism and mutation databases

BioMutaiTBPL2.
DMDMi74749326.

Proteomic databases

EPDiQ6SJ96.
PaxDbiQ6SJ96.
PRIDEiQ6SJ96.

Protocols and materials databases

DNASUi387332.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247219; ENSP00000247219; ENSG00000182521.
GeneIDi387332.
KEGGihsa:387332.
UCSCiuc001xby.5. human.

Organism-specific databases

CTDi387332.
GeneCardsiTBPL2.
HGNCiHGNC:19841. TBPL2.
HPAiHPA056241.
MIMi608964. gene.
neXtProtiNX_Q6SJ96.
PharmGKBiPA134990291.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3302. Eukaryota.
COG2101. LUCA.
GeneTreeiENSGT00410000025389.
HOGENOMiHOG000105164.
HOVERGENiHBG044997.
InParanoidiQ6SJ96.
KOiK03120.
OMAiECCGIVP.
OrthoDBiEOG7XWPPF.
PhylomeDBiQ6SJ96.
TreeFamiTF300102.

Miscellaneous databases

GenomeRNAii387332.
NextBioi101297.
PROiQ6SJ96.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TBPL2.
ExpressionAtlasiQ6SJ96. baseline and differential.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed."
    Persengiev S.P., Zhu X., Dixit B.L., Maston G.A., Kittler E.L.W., Green M.R.
    Proc. Natl. Acad. Sci. U.S.A. 100:14887-14891(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-31.

Entry informationi

Entry nameiTBPL2_HUMAN
AccessioniPrimary (citable) accession number: Q6SJ96
Secondary accession number(s): Q17RU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.