Reviewed, UniProtKB/Swiss-Prot Q6SJ96 (TBPL2_HUMAN)

Names and origin

Protein names

Recommended name:
    TATA box-binding protein-like protein 2
      Short name=TBP-like protein 2
Alternative name(s):
    TATA box-binding protein-related factor 3
      Short name=TBP-related factor 3

Gene names

Name:	TBPL2
Synonyms:	TBP2, TRF3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process By similarity. UniProtKB Q6SJ95
Subunit structure	Interacts with TAF3 By similarity. UniProtKB Q6SJ95
Subcellular location	Cytoplasm. Nucleus. Note: Present in the cytoplasm during cytokenesis. Ref.1
Tissue specificity	Ubiquitously expressed in all tissues examined with highest levels in heart, lung, ovary, spleen and testes. Ref.1 Ref.2
Sequence similarities	Belongs to the TBP family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription initiation from RNA polymerase II promoter Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Ref.1 Inferred from direct assay. Source: UniProtKB transcription factor TFIID complex Inferred from electronic annotation. Source: InterPro
Molecular function	RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	TATA box-binding protein-like protein 2		PRO_0000318118
Regions
	Compositional bias	22 – 26	5	Poly-Pro
Natural variations
	Natural variant	31	1	R → P: dbSNP rs8019270. Ref.3		VAR_038692

Sequences

	Sequence		Length	Mass (Da)
	Q6SJ96-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E55539A49FE76704	FASTA	375	41,524
	10 20 30 40 50 60 MASAPWPERV PRLLAPRLPS YPPPPPTVGL RSMEQEETYL ELYLDQCAAQ DGLAPPRSPL 70 80 90 100 110 120 FSPVVPYDMY ILNASNPDTA FNSNPEVKET SGDFSSVDLS FLPDEVTQEN KDQPVISKHE 130 140 150 160 170 180 TEENSESQSP QSRLPSPSEQ DVGLGLNSSS LSNSHSQLHP GDTDSVQPSP EKPNSDSLSL 190 200 210 220 230 240 ASITPMTPMT PISECCGIVP QLQNIVSTVN LACKLDLKKI ALHAKNAEYN PKRFAAVIMR 250 260 270 280 290 300 IREPRTTALI FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPARFLDF KIQNMVGSCD 310 320 330 340 350 360 VRFPIRLEGL VLTHQQFSSY EPELFPGLIY RMVKPRIVLL IFVSGKVVLT GAKERSEIYE 370 AFENIYPILK GFKKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed." Persengiev S.P., Zhu X., Dixit B.L., Maston G.A., Kittler E.L.W., Green M.R. Proc. Natl. Acad. Sci. U.S.A. 100:14887-14891(2003) [PubMed: 14634207] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Genomics, evolution, and expression of TBPL2, a member of the TBP family." Di Pietro C., Ragusa M., Duro L., Guglielmino M.R., Barbagallo D., Carnemolla A., Lagana A., Buffa P., Angelica R., Rinaldi A., Calafato M.S., Milicia I., Caserta C., Giugno R., Pulvirenti A., Giunta V., Rapisarda A., Di Pietro V. , Grillo A., Messina A., Ferro A., Grzeschik K.H., Purrello M. DNA Cell Biol. 26:369-385(2007) [PubMed: 17570761] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-31.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY457923 mRNA. Translation: AAR24281.1. DQ448593 mRNA. Translation: ABD93323.1. BC117159 mRNA. Translation: AAI17160.1. BC117185 mRNA. Translation: AAI17186.1.
IPI	IPI00791135.
RefSeq	NP_950248.1.
UniGene	Hs.528278
3D structure databases
HSSP	HSSP built from PDB template 1AIS based on UniProtKB P62001.
SMR	Q6SJ96. Positions 197-374.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6SJ96.
Proteomic databases
PRIDE	Q6SJ96.
Genome annotation databases
Ensembl	ENST00000247219; ENSP00000247219; ENSG00000182521; Homo sapiens. [Genome view]
GeneID	387332.
KEGG	hsa:387332.
NMPDR	fig|9606.3.peg.9635.
UCSC	uc001xby.1. human.
Organism-specific databases
CTD	387332.
GeneCards	GC14M054950.
HGNC	HGNC:19841. TBPL2.
MIM	608964. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q6SJ96.
OMA	LYLDQCA.
Gene expression databases
ArrayExpress	Q6SJ96.
CleanEx	HS_TBPL2.
Genevestigator	Q6SJ96.
Family and domain databases
InterPro	IPR012295. b_Adaptin_TBP_C. IPR000814. TBP. [Graphical view]
Gene3D	G3DSA:3.30.310.10. b_Adaptin_TBP_C. 2 hits.
PANTHER	PTHR10126. TBP. 1 hit.
Pfam	PF00352. TBP. 2 hits. [Graphical view]
PRINTS	PR00686. TIFACTORIID.
PROSITE	PS00351. TFIID. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	101297.
SOURCE	Search...

Entry information

Entry name

TBPL2_HUMAN

Accession

Primary (citable) accession number: Q6SJ96
Secondary accession number(s): Q17RU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.