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Protein
Submitted name:

Fn14

Gene

tnfrsf12a

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Fn14Imported
Gene namesi
Name:tnfrsf12aImported
Synonyms:Fn14Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-921794. tnfrsf12a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei69 – 9325HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 12099Sequence analysisPRO_5004279701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 40Combined sources
Disulfide bondi43 ↔ 58Combined sources
Disulfide bondi46 ↔ 55Combined sources

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TNFSF12O435082EBI-8445678,EBI-6932080From a different organism.

Protein-protein interaction databases

IntActiQ6SIX7. 1 interaction.
MINTiMINT-8415055.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KN0NMR-A23-72[»]
ProteinModelPortaliQ6SIX7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6SIX7.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG031553.
KOiK05149.

Family and domain databases

InterProiIPR022316. TNFR_12.
[Graphical view]
PfamiPF12191. stn_TNFRSF12A. 1 hit.
[Graphical view]
PRINTSiPR01962. TNFACTORR12.
ProDomiPD336131. TNFR_12. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q6SIX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPRNLLRTF VPLLLLVLSS AASQGECPEG RAYSQDLGKC MECSVCKNSE
60 70 80 90 100
KSDFCQNCPS KTEQPDFPWI WVIGFSAGGV FLIIVILSLT VYLTHCRRKS
110 120
KFTTPIEETG SHSAEALLIH
Length:120
Mass (Da):13,295
Last modified:July 5, 2004 - v1
Checksum:iF5B5D0BBAA3F7B4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY458020 mRNA. Translation: AAR21225.1.
RefSeqiNP_001083640.1. NM_001090171.1.
UniGeneiXl.34690.

Genome annotation databases

GeneIDi399035.
KEGGixla:399035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY458020 mRNA. Translation: AAR21225.1.
RefSeqiNP_001083640.1. NM_001090171.1.
UniGeneiXl.34690.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KN0NMR-A23-72[»]
ProteinModelPortaliQ6SIX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6SIX7. 1 interaction.
MINTiMINT-8415055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399035.
KEGGixla:399035.

Organism-specific databases

CTDi51330.
XenbaseiXB-GENE-921794. tnfrsf12a.

Phylogenomic databases

HOVERGENiHBG031553.
KOiK05149.

Miscellaneous databases

EvolutionaryTraceiQ6SIX7.

Family and domain databases

InterProiIPR022316. TNFR_12.
[Graphical view]
PfamiPF12191. stn_TNFRSF12A. 1 hit.
[Graphical view]
PRINTSiPR01962. TNFACTORR12.
ProDomiPD336131. TNFR_12. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. Gilbert H.J.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.
  2. "TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules."
    Brown S.A., Hanscom H.N., Vu H., Brew S.A., Winkles J.A.
    Biochem. J. 397:297-304(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.
  3. "Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions."
    Pellegrini M., Willen L., Perroud M., Krushinskie D., Strauch K., Cuervo H., Day E.S., Schneider P., Zheng T.S.
    FEBS J. 280:1818-1829(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 23-72, DISULFIDE BONDS.

Entry informationi

Entry nameiQ6SIX7_XENLA
AccessioniPrimary (citable) accession number: Q6SIX7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.