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Protein

Beta-galactosidase

Gene

lacZ

Organism
Streptococcus thermophilus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotationSAAS annotation (EC:3.2.1.23UniRule annotationSAAS annotation)
Alternative name(s):
LactaseUniRule annotation
Gene namesi
Name:lacZImported
OrganismiStreptococcus thermophilusImported
Taxonomic identifieri1308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliQ6SCP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 218Glyco_hydro_2_NInterPro annotationAdd BLAST173
Domaini220 – 322Glyco_hydro_2InterPro annotationAdd BLAST103
Domaini324 – 637Glyco_hydro_2_CInterPro annotationAdd BLAST314
Domaini644 – 729DUF4981InterPro annotationAdd BLAST86
Domaini754 – 851Bgal_small_NInterPro annotationAdd BLAST98

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CNT. Bacteria.
COG3250. LUCA.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
2.70.98.10. 1 hit.
InterProiView protein in InterPro
IPR004199. B-gal_small/dom_5.
IPR036156. beta-gal/glucu_dom_sf.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. GH-type_carb-bd.
IPR006101. Glyco_hydro_2.
IPR023232. Glyco_hydro_2_AS.
IPR006103. Glyco_hydro_2_cat.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR032312. LacZ_4.
PfamiView protein in Pfam
PF02929. Bgal_small_N. 1 hit.
PF16353. DUF4981. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
PRINTSiPR00132. GLHYDRLASE2.
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiView protein in PROSITE
PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6SCP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTEKIQTY LNDPKIVSVN TVDAHSDHKY FESLAEFSEG EMKLRQSLNG
60 70 80 90 100
KWKIHYAQNT NQVLKDFYKT EFDETDLNFI NVPGHLELQG FGSPQYVNTQ
110 120 130 140 150
YPWDGKEFLR PPQVPQESNA VASYVKHFTL NDALKDKKVF ISFQGVATSI
160 170 180 190 200
FVWVNGNFVG YSEDSFTPSE FEISDYLVEG DNKLAVAVYR YSTASWLEDQ
210 220 230 240 250
DFWRLYGIFR DVYLYAIPKV HVQDLFVKGD YDYQTKAGQL DIDLKTVGDY
260 270 280 290 300
EDKKIKYVLS DYEGIVTEGD ASVNGDGELS VSLENLKIKP WSAESPKLYN
310 320 330 340 350
LILHVLDDDQ VVEVVPVKVG FRRFEIKDKL MLLNGKRIVF KGVNRHEFNA
360 370 380 390 400
RTGRCITEED MLWDIKVMKQ HNINAVRTSH YPNQTRWYEL CDEYGLYVID
410 420 430 440 450
EANLETHGTW QKLGLCELSW NIPVSEPEWL PACLDRANNM FQRDKNHASV
460 470 480 490 500
IIWSCGNESY AGKDIADMAD YFRSVDNTRP VHYEGVAWCR EFDYITDIES
510 520 530 540 550
RMYAKPADIE EYLTTGKLVD LSRVSDKHFA SGNLTNNPQK PYISCEYMHT
560 570 580 590 600
MGNSGGGLEL YTDLEKYPEY QGGFIWDFID QAIYKTLPNG SEFLSYGGDW
610 620 630 640 650
HDRPSDYEFC GNGIVFADRT LTPKLQTVKH LYSNIKIAVD EKSVTIKNDN
660 670 680 690 700
VFEDLSAYTF LARVYEDGRK VSESEYHFDV KPGEEATFPV NFVVESSNSE
710 720 730 740 750
QIYEVACVLR EATEWAPKGH EIVRGQYVVE KISTETPVKA PLNVVEGDFN
760 770 780 790 800
IGIQGQNFSI LLSRAQNTLV SAKYNGVEFI EKGPKLNFTR AYTDNDRGAG
810 820 830 840 850
YPFEMAGWKV AGNYSKVTDT QIQIEDDSVK VTYVHELPGL SDVEVKVTYQ

VD
Length:852
Mass (Da):97,542
Last modified:July 5, 2004 - v1
Checksum:iB73B0AF07F96625D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei852Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY460092 Genomic DNA. Translation: AAR22439.1.

Similar proteinsi

Entry informationi

Entry nameiQ6SCP4_STRTR
AccessioniPrimary (citable) accession number: Q6SCP4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)