Q6SA80 (RND3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho-related GTP-binding protein RhoE

Alternative name(s):
Rho family GTPase 3
Rnd3

Gene names

Name:	Rnd3
Synonyms:	Arhe, Rhoe

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins By similarity.
Subunit structure	Binds ROCK1. Interacts with UBXD5 By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rho family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Rho-related GTP-binding protein RhoE		PRO_0000198881
	Propeptide	242 – 244	3	Removed in mature form By similarity		PRO_0000281234
Regions
	Nucleotide binding	30 – 37	8	GTP By similarity
	Nucleotide binding	77 – 81	5	GTP By similarity
	Nucleotide binding	135 – 138	4	GTP By similarity
	Motif	52 – 60	9	Effector region Potential
Amino acid modifications
	Modified residue	241	1	Cysteine methyl ester By similarity
	Lipidation	241	1	S-farnesyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6SA80 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: DD2D4021CD42BACC	FASTA	244	27,368
	10 20 30 40 50 60 MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY 70 80 90 100 110 120 TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE 130 140 150 160 170 180 IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL 190 200 210 220 230 240 QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS CTVM

References

[1]	"Identification of RhoE as a gene modulated by heat shock in rat cardiomyocytes." Gill C.M., Stenson-Cox C., Samali A. Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BDIX. Tissue: Embryonic heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY461427 mRNA. Translation: AAR23526.1.
IPI	IPI00205497.
RefSeq	NP_001007642.1. NM_001007641.1.
UniGene	Rn.25153.
3D structure databases
ProteinModelPortal	Q6SA80.
ModBase	Search...
Proteomic databases
PaxDb	Q6SA80.
PRIDE	Q6SA80.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000006111; ENSRNOP00000006111; ENSRNOG00000004624.
GeneID	295588.
KEGG	rno:295588.
UCSC	RGD:1359690. rat.
Organism-specific databases
CTD	390.
RGD	1359690. Rnd3.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00700000104387.
HOGENOM	HOG000233974.
HOVERGEN	HBG009351.
InParanoid	Q6SA80.
KO	K07859.
OMA	VELSTHR.
OrthoDB	EOG4W6NWT.
Gene expression databases
ArrayExpress	Q6SA80.
Genevestigator	Q6SA80.
GermOnline	ENSRNOG00000004624. Rattus norvegicus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003578. Small_GTPase_Rho. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00174. RHO. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51420. RHO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	639748.

Entry information

Entry name

RND3_RAT

Accession

Primary (citable) accession number: Q6SA80

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program