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Protein

Rho-related GTP-binding protein RhoE

Gene

Rnd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378GTPBy similarity
Nucleotide bindingi77 – 815GTPBy similarity
Nucleotide bindingi135 – 1384GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoE
Alternative name(s):
Rho family GTPase 3
Rnd3
Gene namesi
Name:Rnd3
Synonyms:Arhe, Rhoe
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1359690. Rnd3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Rho-related GTP-binding protein RhoEPRO_0000198881Add
BLAST
Propeptidei242 – 2443Removed in mature formBy similarityPRO_0000281234

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei241 – 2411Cysteine methyl esterBy similarity
Lipidationi241 – 2411S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ6SA80.
PRIDEiQ6SA80.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004624.
ExpressionAtlasiQ6SA80. baseline and differential.
GenevisibleiQ6SA80. RN.

Interactioni

Subunit structurei

Binds ROCK1. Interacts with UBXD5 (By similarity).By similarity

Protein-protein interaction databases

BioGridi255043. 1 interaction.
STRINGi10116.ENSRNOP00000006111.

Structurei

3D structure databases

ProteinModelPortaliQ6SA80.
SMRiQ6SA80. Positions 22-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi52 – 609Effector regionSequence analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ6SA80.
KOiK07859.
OMAiMKERRPC.
OrthoDBiEOG091G0M4M.
PhylomeDBiQ6SA80.
TreeFamiTF330887.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6SA80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE
60 70 80 90 100
NYVPTVFENY TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI
110 120 130 140 150
CFDISRPETL DSVLKKWKGE IQEFCPNTKM LLVGCKSDLR TDVSTLVELS
160 170 180 190 200
NHRQTPVSYD QGANMAKQIG AATYIECSAL QSENSVRDIF HVATLACVNK
210 220 230 240
TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS CTVM
Length:244
Mass (Da):27,368
Last modified:July 5, 2004 - v1
Checksum:iDD2D4021CD42BACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461427 mRNA. Translation: AAR23526.1.
RefSeqiNP_001007642.1. NM_001007641.1.
UniGeneiRn.25153.

Genome annotation databases

EnsembliENSRNOT00000006111; ENSRNOP00000006111; ENSRNOG00000004624.
GeneIDi295588.
KEGGirno:295588.
UCSCiRGD:1359690. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461427 mRNA. Translation: AAR23526.1.
RefSeqiNP_001007642.1. NM_001007641.1.
UniGeneiRn.25153.

3D structure databases

ProteinModelPortaliQ6SA80.
SMRiQ6SA80. Positions 22-200.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi255043. 1 interaction.
STRINGi10116.ENSRNOP00000006111.

Proteomic databases

PaxDbiQ6SA80.
PRIDEiQ6SA80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006111; ENSRNOP00000006111; ENSRNOG00000004624.
GeneIDi295588.
KEGGirno:295588.
UCSCiRGD:1359690. rat.

Organism-specific databases

CTDi390.
RGDi1359690. Rnd3.

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ6SA80.
KOiK07859.
OMAiMKERRPC.
OrthoDBiEOG091G0M4M.
PhylomeDBiQ6SA80.
TreeFamiTF330887.

Miscellaneous databases

PROiQ6SA80.

Gene expression databases

BgeeiENSRNOG00000004624.
ExpressionAtlasiQ6SA80. baseline and differential.
GenevisibleiQ6SA80. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRND3_RAT
AccessioniPrimary (citable) accession number: Q6SA80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.