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Protein

Rho-related GTP-binding protein RhoE

Gene

Rnd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37GTPBy similarity8
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoE
Alternative name(s):
Rho family GTPase 3
Rnd3
Gene namesi
Name:Rnd3
Synonyms:Arhe, Rhoe
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1359690 Rnd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988811 – 241Rho-related GTP-binding protein RhoEAdd BLAST241
PropeptideiPRO_0000281234242 – 244Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei241Cysteine methyl esterBy similarity1
Lipidationi241S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ6SA80

Expressioni

Gene expression databases

BgeeiENSRNOG00000004624
ExpressionAtlasiQ6SA80 baseline and differential
GenevisibleiQ6SA80 RN

Interactioni

Subunit structurei

Binds ROCK1. Interacts with UBXD5 (By similarity).By similarity

Protein-protein interaction databases

BioGridi255043, 1 interactor
STRINGi10116.ENSRNOP00000006111

Structurei

3D structure databases

ProteinModelPortaliQ6SA80
SMRiQ6SA80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi52 – 60Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiQ6SA80
KOiK07859
OMAiERRPCQK
OrthoDBiEOG091G0M4M
PhylomeDBiQ6SA80
TreeFamiTF330887

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6SA80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE
60 70 80 90 100
NYVPTVFENY TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI
110 120 130 140 150
CFDISRPETL DSVLKKWKGE IQEFCPNTKM LLVGCKSDLR TDVSTLVELS
160 170 180 190 200
NHRQTPVSYD QGANMAKQIG AATYIECSAL QSENSVRDIF HVATLACVNK
210 220 230 240
TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS CTVM
Length:244
Mass (Da):27,368
Last modified:July 5, 2004 - v1
Checksum:iDD2D4021CD42BACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461427 mRNA Translation: AAR23526.1
RefSeqiNP_001007642.1, NM_001007641.1
UniGeneiRn.25153

Genome annotation databases

EnsembliENSRNOT00000006111; ENSRNOP00000006111; ENSRNOG00000004624
GeneIDi295588
KEGGirno:295588
UCSCiRGD:1359690 rat

Similar proteinsi

Entry informationi

Entry nameiRND3_RAT
AccessioniPrimary (citable) accession number: Q6SA80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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