Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 474

Gene

ZNF474

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri166 – 189C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 474
Alternative name(s):
Testis-specific zinc finger protein
Short name:
TSZFP
Gene namesi
Name:ZNF474
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:23245. ZNF474.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164185.
PharmGKBiPA144596519.

Polymorphism and mutation databases

BioMutaiZNF474.
DMDMi74758522.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804141 – 364Zinc finger protein 474Add BLAST364

Proteomic databases

EPDiQ6S9Z5.
PaxDbiQ6S9Z5.
PRIDEiQ6S9Z5.

PTM databases

iPTMnetiQ6S9Z5.
PhosphoSitePlusiQ6S9Z5.

Expressioni

Gene expression databases

BgeeiENSG00000164185.
CleanExiHS_ZNF474.
ExpressionAtlasiQ6S9Z5. baseline and differential.
GenevisibleiQ6S9Z5. HS.

Organism-specific databases

HPAiHPA036595.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296600.

Structurei

3D structure databases

ProteinModelPortaliQ6S9Z5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri166 – 189C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IH9U. Eukaryota.
ENOG41108Y5. LUCA.
GeneTreeiENSGT00530000064208.
HOGENOMiHOG000013080.
HOVERGENiHBG063271.
InParanoidiQ6S9Z5.
OMAiHSKEPTF.
OrthoDBiEOG091G0X7D.
PhylomeDBiQ6S9Z5.
TreeFamiTF328720.

Family and domain databases

InterProiIPR026319. ZC2HC1.
IPR007087. Znf_C2H2.
[Graphical view]
PANTHERiPTHR13555. PTHR13555. 1 hit.
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6S9Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERGKKKRIS NKLQQTFHHS KEPTFLINQA GLLSSDSYSS LSPETESVNP
60 70 80 90 100
GENIKTDTQK KRPGTVILSK LSSRRIISES QLSPPVIPAR RPGFRVCYIC
110 120 130 140 150
GREFGSQSIA IHEPQCLQKW HIENSKLPKH LRRPEPSKPQ SLSSSGSYSL
160 170 180 190 200
QATNEAAFQS AQAQLLPCES CGRTFLPDHL LVHHRSCKPK GEGPRAPHSN
210 220 230 240 250
SSDHLTGLKK ACSGTPARPR TVICYICGKE FGTLSLPIHE PKCLEKWKME
260 270 280 290 300
NDRLPVELHQ PLPQKPQPLP NAQSSQAGPN QAQLVFCPHC SRIFTSDRLL
310 320 330 340 350
VHQRSCKTHP YGPKYQNLNL GSKGGLKEYT NSKQQRNRAA PSVTDKVIHA
360
TQDALGEPGG ALCL
Length:364
Mass (Da):40,315
Last modified:July 5, 2004 - v1
Checksum:i3A9467A1C118DE7C
GO

Sequence cautioni

The sequence BAB71507 differs from that shown. Reason: Frameshift at position 318.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031146173R → H.Corresponds to variant rs2560306dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461732 mRNA. Translation: AAS21253.1.
AK057483 mRNA. Translation: BAB71507.1. Frameshift.
AK290985 mRNA. Translation: BAF83674.1.
CH471086 Genomic DNA. Translation: EAW48893.1.
BC133022 mRNA. Translation: AAI33023.1.
BC133026 mRNA. Translation: AAI33027.1.
CCDSiCCDS4130.1.
RefSeqiNP_997200.1. NM_207317.2.
UniGeneiHs.729673.

Genome annotation databases

EnsembliENST00000296600; ENSP00000296600; ENSG00000164185.
GeneIDi133923.
KEGGihsa:133923.
UCSCiuc003ksv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461732 mRNA. Translation: AAS21253.1.
AK057483 mRNA. Translation: BAB71507.1. Frameshift.
AK290985 mRNA. Translation: BAF83674.1.
CH471086 Genomic DNA. Translation: EAW48893.1.
BC133022 mRNA. Translation: AAI33023.1.
BC133026 mRNA. Translation: AAI33027.1.
CCDSiCCDS4130.1.
RefSeqiNP_997200.1. NM_207317.2.
UniGeneiHs.729673.

3D structure databases

ProteinModelPortaliQ6S9Z5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000296600.

PTM databases

iPTMnetiQ6S9Z5.
PhosphoSitePlusiQ6S9Z5.

Polymorphism and mutation databases

BioMutaiZNF474.
DMDMi74758522.

Proteomic databases

EPDiQ6S9Z5.
PaxDbiQ6S9Z5.
PRIDEiQ6S9Z5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296600; ENSP00000296600; ENSG00000164185.
GeneIDi133923.
KEGGihsa:133923.
UCSCiuc003ksv.4. human.

Organism-specific databases

CTDi133923.
GeneCardsiZNF474.
HGNCiHGNC:23245. ZNF474.
HPAiHPA036595.
neXtProtiNX_Q6S9Z5.
OpenTargetsiENSG00000164185.
PharmGKBiPA144596519.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH9U. Eukaryota.
ENOG41108Y5. LUCA.
GeneTreeiENSGT00530000064208.
HOGENOMiHOG000013080.
HOVERGENiHBG063271.
InParanoidiQ6S9Z5.
OMAiHSKEPTF.
OrthoDBiEOG091G0X7D.
PhylomeDBiQ6S9Z5.
TreeFamiTF328720.

Miscellaneous databases

ChiTaRSiZNF474. human.
GenomeRNAii133923.
PROiQ6S9Z5.

Gene expression databases

BgeeiENSG00000164185.
CleanExiHS_ZNF474.
ExpressionAtlasiQ6S9Z5. baseline and differential.
GenevisibleiQ6S9Z5. HS.

Family and domain databases

InterProiIPR026319. ZC2HC1.
IPR007087. Znf_C2H2.
[Graphical view]
PANTHERiPTHR13555. PTHR13555. 1 hit.
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN474_HUMAN
AccessioniPrimary (citable) accession number: Q6S9Z5
Secondary accession number(s): A8K4M0, Q96M07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.