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Q6S9V9

- CISY_THUAL

UniProt

Q6S9V9 - CISY_THUAL

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Protein

Citrate synthase, mitochondrial

Gene
cs
Organism
Thunnus albacares (Yellowfin tuna) (Neothunnus macropterus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei304 – 3041 By similarity
Active sitei350 – 3501 By similarity
Active sitei405 – 4051 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:cs
OrganismiThunnus albacares (Yellowfin tuna) (Neothunnus macropterus)
Taxonomic identifieri8236 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagimorphariaScombriformesScombridaeThunnus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030Mitochondrion By similarityAdd
BLAST
Chaini31 – 469439Citrate synthase, mitochondrialPRO_0000253906Add
BLAST

Proteomic databases

PRIDEiQ6S9V9.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6S9V9.
SMRiQ6S9V9. Positions 31-467.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005336.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6S9V9-1 [UniParc]FASTAAdd to Basket

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MSFLSVSRLA PKLLNSKNAT YFLVAARNAS ASTTNLKDVL ADLIPKEQSR    50
IKNFKQQYGK TNIGQITVDM VYGGMRGMKG LVYETSVLDP EEGIRFRGYS 100
IPECQKLLPK APGGEEPLPE GLFWLLVTGQ VPTEEQVNWV SKEWAKRAAL 150
PSHVVTMLDN FPTNLHPMSQ FSAAITALNS ESSFARAYSE GVHKTKYWEF 200
VYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDSNLDWS HNFTNMLGYS 250
EAQFTELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL SFSAAMNGLA 300
GPLHGLANQE VLVWLTALQK EMGGEVSDER MRDYIWNTLK SGRVVPGYGH 350
AVLRKTDPRY TCQREFALKH LPNDPMFKLV AQLYKIVPNV LLEQGKAKNP 400
WPNVDAHSGV LLQYYGMTEM NYYTVLFGVS RALGVLAQLV WSRALGFPLE 450
RPKSMSTEGL MTLVGAKSG 469
Length:469
Mass (Da):52,191
Last modified:July 5, 2004 - v1
Checksum:iBC5E52A73D3CA1A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY461848 mRNA. Translation: AAR98858.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY461848 mRNA. Translation: AAR98858.1 .

3D structure databases

ProteinModelPortali Q6S9V9.
SMRi Q6S9V9. Positions 31-467.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6S9V9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005336.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial enzyme content in the muscles of high-performance fish: evolution and variation among fiber types."
    Dalziel A.C., Moore S.E., Moyes C.D.
    Am. J. Physiol. 288:R163-R172(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Red muscle.

Entry informationi

Entry nameiCISY_THUAL
AccessioniPrimary (citable) accession number: Q6S9V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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