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Q6S9V8

- CISY_THUOB

UniProt

Q6S9V8 - CISY_THUOB

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Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Thunnus obesus (Bigeye tuna)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei304 – 3041PROSITE-ProRule annotation
Active sitei350 – 3501PROSITE-ProRule annotation
Active sitei405 – 4051PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:cs
OrganismiThunnus obesus (Bigeye tuna)
Taxonomic identifieri8241 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagiariaScombriformesScombridaeThunnus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 469439Citrate synthase, mitochondrialPRO_0000253907Add
BLAST

Proteomic databases

PRIDEiQ6S9V8.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6S9V8.
SMRiQ6S9V8. Positions 31-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005336.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6S9V8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFLSVSRLA PKLLNSKNAT YFLVAARNAS ASTTNLKDVL ADLIPKEQSR
60 70 80 90 100
IKNFKQQYGK TNIGQITVDM VYGGMRGMKG LVYETSVLDP EEGIRFRGYS
110 120 130 140 150
IPECQKLLPK APGGEEPLPE GLFWLLVTGQ VPTEEQVNWV SKEWAKRAAL
160 170 180 190 200
PSHVVTMLDN FPTNLHPMSQ FSAAITALNS ESSFARAYSE GVHKTKYWEF
210 220 230 240 250
VYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDSNLDWS HNFTNMLGYS
260 270 280 290 300
EAQFTELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL SFSAAMNGLA
310 320 330 340 350
GPLHGLANQE VLVWLTALQK EMGGEVSDER MRDYIWNTLK SGRVVPGYGH
360 370 380 390 400
AVLRKTDPRY TCQREFALKH LPNDPMFKLV AQLYKIVPNV LLEQGKAKNP
410 420 430 440 450
WPNVDAHSGV LLQYYGMTEM NYYTVLFGVS RALGVLAQLV WSRALGFPLE
460
RPKSMSTEGL MTLVGAKSG
Length:469
Mass (Da):52,191
Last modified:July 5, 2004 - v1
Checksum:iBC5E52A73D3CA1A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY461849 mRNA. Translation: AAR98859.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY461849 mRNA. Translation: AAR98859.1 .

3D structure databases

ProteinModelPortali Q6S9V8.
SMRi Q6S9V8. Positions 31-467.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6S9V8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005336.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial enzyme content in the muscles of high-performance fish: evolution and variation among fiber types."
    Dalziel A.C., Moore S.E., Moyes C.D.
    Am. J. Physiol. 288:R163-R172(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Red muscle.

Entry informationi

Entry nameiCISY_THUOB
AccessioniPrimary (citable) accession number: Q6S9V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3