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Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Katsuwonus pelamis (Skipjack tuna) (Bonito)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei304 – 3041PROSITE-ProRule annotation
Active sitei350 – 3501PROSITE-ProRule annotation
Active sitei405 – 4051PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:cs
OrganismiKatsuwonus pelamis (Skipjack tuna) (Bonito)
Taxonomic identifieri8226 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagiariaScombriformesScombridaeKatsuwonus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 469439Citrate synthase, mitochondrialPRO_0000253903Add
BLAST

Proteomic databases

PRIDEiQ6S9V7.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6S9V7.
SMRiQ6S9V7. Positions 31-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005336.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6S9V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLSVSRLA PKLLNSKNAT YFLVAARNAS ASTTNLKDVL SDLIPKEQSR
60 70 80 90 100
IKNFKQQYGK TNIGQITVDM VYGGMRGMKG LVYETSVLDP EEGIRFRGYS
110 120 130 140 150
IPECQKLLPK APGGEEPLPE GLFWLLVTGQ VPTEEQVKWV SKEWAKRAAL
160 170 180 190 200
PSHVVTMLDN FPTNLHPMSQ FSAAITALNS ESSFARAYSE GVHKTKYWEF
210 220 230 240 250
VYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDSNLDWS HNFTNMLGYS
260 270 280 290 300
EAQFTELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL SFSAAMNGLA
310 320 330 340 350
GPLHGLANQE VLVWLTALQK EMGGEVSDER MRDYIWNTLK SGRVVPGYGH
360 370 380 390 400
AVLRKTDPRY TCQREFALKH LPNDPMFKLV AQLYKIVPNV LLEQGKAKNP
410 420 430 440 450
WPNVDAHSGV LLQYYGMTEM NYYTVLFGVS RALGVLAQLV WSRALGFPLE
460
RPKSMSTDGL MTLVGAKSG
Length:469
Mass (Da):52,207
Last modified:July 5, 2004 - v1
Checksum:i39C25C2F81DB2CF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461850 mRNA. Translation: AAR98860.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461850 mRNA. Translation: AAR98860.1.

3D structure databases

ProteinModelPortaliQ6S9V7.
SMRiQ6S9V7. Positions 31-467.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6S9V7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005336.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mitochondrial enzyme content in the muscles of high-performance fish: evolution and variation among fiber types."
    Dalziel A.C., Moore S.E., Moyes C.D.
    Am. J. Physiol. 288:R163-R172(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Red muscle.

Entry informationi

Entry nameiCISY_KATPE
AccessioniPrimary (citable) accession number: Q6S9V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.