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Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Xiphias gladius (Swordfish) (Tetrapterus imperator)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathway: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase, mitochondrial (cs)
  2. no protein annotated in this organism
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei304 – 3041PROSITE-ProRule annotation
Active sitei350 – 3501PROSITE-ProRule annotation
Active sitei405 – 4051PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:cs
OrganismiXiphias gladius (Swordfish) (Tetrapterus imperator)
Taxonomic identifieri8245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangariaIstiophoriformesXiphiidaeXiphias

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 469439Citrate synthase, mitochondrialPRO_0000253908Add
BLAST

Proteomic databases

PRIDEiQ6S9V6.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6S9V6.
SMRiQ6S9V6. Positions 31-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005336.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6S9V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLTVSRLA PKLLNSKNAT YFLVAARNAS ASSTNLKDVL ADLIPKEQTR
60 70 80 90 100
IKNFKQQYGK TNIGQITVDM VYGGMRGMKG LVYETSVLDP EEGIRFRGYS
110 120 130 140 150
IPECQELLPK APGGEEPLPE GLFWLLVTGQ VPTEEQVNWV SKEWAKRAAL
160 170 180 190 200
PSHVVTMLDN FPTNLHPMSQ FSAAITALNS ESSFARAYSE GVHKTKYWEF
210 220 230 240 250
IYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDSNLDWS HNFTNMLGYS
260 270 280 290 300
EPQFTELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL SFSAAMNGLA
310 320 330 340 350
GPLHGLANQE VLVWLTALQK ELGGEVSDER MRDYIWNTLK SGRVVPGYGH
360 370 380 390 400
AVLRKTDPRY TCQREFALKH LPNDPMFKLV AQLYKIVPNV LLEQGKAKNP
410 420 430 440 450
WPNVDAHSGV LLQYYGMTEM NYYTVLFGVS RALGVLAQLV WSRALGFPLE
460
RPKSMSTDGL MTLVGAKSG
Length:469
Mass (Da):52,214
Last modified:July 5, 2004 - v1
Checksum:i75483B471DAB74D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461851 mRNA. Translation: AAR98861.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461851 mRNA. Translation: AAR98861.1.

3D structure databases

ProteinModelPortaliQ6S9V6.
SMRiQ6S9V6. Positions 31-467.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6S9V6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005336.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mitochondrial enzyme content in the muscles of high-performance fish: evolution and variation among fiber types."
    Dalziel A.C., Moore S.E., Moyes C.D.
    Am. J. Physiol. 288:R163-R172(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Red muscle.

Entry informationi

Entry nameiCISY_XIPGL
AccessioniPrimary (citable) accession number: Q6S9V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.