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Q6S9V5 (CISY_TETAD) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase, mitochondrial

EC=2.3.3.1
Alternative name(s):
Citrate (Si)-synthase
Gene names
Name:cs
OrganismTetrapturus audax (Striped marlin) (Kajikia audax)
Taxonomic identifier13721 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangimorphariaeIstiophoriformesKjikia

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3030Mitochondrion By similarity
Chain31 – 469439Citrate synthase, mitochondrial
PRO_0000253904

Sites

Active site3041 By similarity
Active site3501 By similarity
Active site4051 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6S9V5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5DEB928051938CBB

FASTA46952,213
        10         20         30         40         50         60 
MSFLTVSRLA PKLLNSKNAT YFLVAARNAS ASSTNLKDVL ADLIPKEQTR IKNFKQQYGK 

        70         80         90        100        110        120 
TNIGQITVDM VYGGMRGMKG LVYETSVLDP EEGIRFRGYS IPECQKLLPK APGGEEPLPE 

       130        140        150        160        170        180 
GLFWLLVTGQ VPTEEQVNWV SKEWAKRAAL PSHVVTMLDN FPTNLHPMSQ FSAAITALNS 

       190        200        210        220        230        240 
ESSFARAYSE GVHKSKYWEF IYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDSNLDWS 

       250        260        270        280        290        300 
HNFTNMLGYS EPQFTELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL SFSAAMNGLA 

       310        320        330        340        350        360 
GPLHGLANQE VLVWLTALQK ELGGEVSDER MRDYIWNTLK SGRVVPGYGH AVLRKTDPRY 

       370        380        390        400        410        420 
TCQREFALKH LPNDPMFKLV AQLYKIVPNV LLEQGRAKNP WPNVDAHSGV LLQYYGMTEM 

       430        440        450        460 
NYYTVLFGVS RALGVLAQLV WSRALGFPLE RPKSMSSDGL MTLVGAKSG 

« Hide

References

[1]"Mitochondrial enzyme content in the muscles of high-performance fish: evolution and variation among fiber types."
Dalziel A.C., Moore S.E., Moyes C.D.
Am. J. Physiol. 288:R163-R172(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Red muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY461852 mRNA. Translation: AAR98862.1.

3D structure databases

ProteinModelPortalQ6S9V5.
SMRQ6S9V5. Positions 31-467.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005336.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01793. cit_synth_euk. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_TETAD
AccessionPrimary (citable) accession number: Q6S9V5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways