Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

HMW kininogen-II

Gene

Kng2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitorPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Protein family/group databases

MEROPSiI25.950.

Names & Taxonomyi

Protein namesi
Submitted name:
HMW kininogen-IIImported
Submitted name:
Kininogen 2Imported
Gene namesi
Name:Kng2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:3027157. Kng2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501014251224 – 644Sequence analysisAdd BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 96PROSITE-ProRule annotation
Disulfide bondi83 ↔ 94PROSITE-ProRule annotation
Disulfide bondi228 ↔ 247PROSITE-ProRule annotation
Disulfide bondi350 ↔ 369PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000060459.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097623.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 131Cystatin kininogen-typeInterPro annotationAdd BLAST104
Domaini150 – 253Cystatin kininogen-typeInterPro annotationAdd BLAST104
Domaini272 – 375Cystatin kininogen-typeInterPro annotationAdd BLAST104

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IKIQ. Eukaryota.
ENOG4111ZQ8. LUCA.
GeneTreeiENSGT00440000039713.
HOGENOMiHOG000113239.
HOVERGENiHBG006224.
OMAiRITETNC.
OrthoDBiEOG091G0SH2.
TreeFamiTF351852.

Family and domain databases

CDDicd00042. CY. 3 hits.
InterProiView protein in InterPro
IPR000010. Cystatin_dom.
IPR002395. Kininogen.
IPR027358. Kininogen-type_cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
PfamiView protein in Pfam
PF00031. Cystatin. 3 hits.
PRINTSiPR00334. KININOGEN.
SMARTiView protein in SMART
SM00043. CY. 3 hits.
PROSITEiView protein in PROSITE
PS00287. CYSTATIN. 1 hit.
PS51647. CYSTATIN_KININOGEN. 3 hits.

Sequencei

Sequence statusi: Complete.

Q6S9I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLITTLLLC SGLLLTLTQG EEAQEIDCND EAVFQAVDAS LKKLNARLQS
60 70 80 90 100
GNQFVLYRVT KRAKMDGSAT FYSFNYQIKE GNCSAQRGLA WQDCDFKDSE
110 120 130 140 150
EAATGECTAT MGKKENKFFI VTQTCKITPG KGPIVTEEYH CASCVHPISA
160 170 180 190 200
DNPDLEPVLK HAIEYFNNNT GHSHLFALRE VKSAQGQVVG GLNFDIIYTI
210 220 230 240 250
VQTNCSKERF PSLRGDCVAL PNGDGGECRG NAFLDTDNKI EDFTQSCDLH
260 270 280 290 300
PGDDLVEALP KPCPGCPRDI PVDSPELKEV LGHSIAQLNT ENDHPFYFKI
310 320 330 340 350
DTVKKATSQV VAGTNYVIEF IARETKCSKE SNTELTEDCE IKHLGQSLDC
360 370 380 390 400
NANVYMRPWE NKVIPTVKCQ ALDKTIPIRR RPPGFSPFRS AKVQETKAGT
410 420 430 440 450
TVSPPYIVRE QKEGNGWLNE KQIKAKNHSG HKYGHDHAHW SPRRHGLGHG
460 470 480 490 500
HQKPHGLGHG HRLKLDYLRH QREDGSDHTH TEGHGYGHGH GHGHGHGHSH
510 520 530 540 550
GLGHGHDKQT NKDKSSVKQT AQRTEPLASS SEYSTTSTQI QERTEGPTLT
560 570 580 590 600
PPRAQPTVTS SGFQDSDFIE DVVAITPPYD TGAPDDLIPD IHVQPDSLSF
610 620 630 640
KLISDFPEAT SQKCPGRPWK PASWKDPNTE TTEFSDFDLL DVLS
Length:644
Mass (Da):71,272
Last modified:July 5, 2004 - v1
Checksum:i5204B683114F565B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154540 Genomic DNA. No translation available.
CT027991 Genomic DNA. No translation available.
AY462056 mRNA. Translation: AAR88630.1.
RefSeqiNP_958763.1. NM_201375.2.
UniGeneiMm.440414.

Genome annotation databases

EnsembliENSMUST00000100046; ENSMUSP00000097623; ENSMUSG00000060459.
GeneIDi385643.
UCSCiuc007ysz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154540 Genomic DNA. No translation available.
CT027991 Genomic DNA. No translation available.
AY462056 mRNA. Translation: AAR88630.1.
RefSeqiNP_958763.1. NM_201375.2.
UniGeneiMm.440414.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097623.

Protein family/group databases

MEROPSiI25.950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100046; ENSMUSP00000097623; ENSMUSG00000060459.
GeneIDi385643.
UCSCiuc007ysz.1. mouse.

Organism-specific databases

CTDi385643.
MGIiMGI:3027157. Kng2.

Phylogenomic databases

eggNOGiENOG410IKIQ. Eukaryota.
ENOG4111ZQ8. LUCA.
GeneTreeiENSGT00440000039713.
HOGENOMiHOG000113239.
HOVERGENiHBG006224.
OMAiRITETNC.
OrthoDBiEOG091G0SH2.
TreeFamiTF351852.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiKng2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060459.

Family and domain databases

CDDicd00042. CY. 3 hits.
InterProiView protein in InterPro
IPR000010. Cystatin_dom.
IPR002395. Kininogen.
IPR027358. Kininogen-type_cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
PfamiView protein in Pfam
PF00031. Cystatin. 3 hits.
PRINTSiPR00334. KININOGEN.
SMARTiView protein in SMART
SM00043. CY. 3 hits.
PROSITEiView protein in PROSITE
PS00287. CYSTATIN. 1 hit.
PS51647. CYSTATIN_KININOGEN. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6S9I3_MOUSE
AccessioniPrimary (citable) accession number: Q6S9I3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.