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Protein
Submitted name:

HMW-kininogen-II variant

Gene

Kng2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Protein family/group databases

MEROPSiI25.019.

Names & Taxonomyi

Protein namesi
Submitted name:
HMW-kininogen-II variantImported
Submitted name:
Kng2 proteinImported
Submitted name:
Protein Kng2Imported
Gene namesi
Name:Kng2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:3027157. Kng2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 462439Sequence analysisPRO_5007925999Add
BLAST

Expressioni

Gene expression databases

BgeeiENSMUSG00000060459.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097623.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 131104Cystatin kininogen-typeInterPro annotationAdd
BLAST
Domaini150 – 253104Cystatin kininogen-typeInterPro annotationAdd
BLAST
Domaini272 – 375104Cystatin kininogen-typeInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IKIQ. Eukaryota.
ENOG4111ZQ8. LUCA.
GeneTreeiENSGT00440000039713.
HOGENOMiHOG000113239.
HOVERGENiHBG006224.
KOiK03898.

Family and domain databases

InterProiIPR000010. Cystatin_dom.
IPR027358. Kininogen-type_cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PfamiPF00031. Cystatin. 3 hits.
[Graphical view]
SMARTiSM00043. CY. 3 hits.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
PS51647. CYSTATIN_KININOGEN. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6S9I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLITTLLLC SGLLLTLTQG EEAQEIDCND EAVFQAVDAS LKKLNARLQS
60 70 80 90 100
GNQFVLYRVT KRAKMDGSAT FYSFNYQIKE GNCSAQRGLA WQDCDFKDSE
110 120 130 140 150
EAATGECTAT MGKKENKFFI VTQTCKITPG KGPIVTEEYH CASCVHPISA
160 170 180 190 200
DNPDLEPVLK HAIEYFNNNT GHSHLFALRE VKSAQGQVVG GLNFDIIYTI
210 220 230 240 250
VQTNCSKERF PSLRGDCVAL PNGDGGECRG NAFLDTDNKI EDFTQSCDLH
260 270 280 290 300
PGDDLVEALP KPCPGCPRDI PVDSPELKEV LGHSIAQLNT ENDHPFYFKI
310 320 330 340 350
DTVKKATSQV VAGTNYVIEF IARETKCSKE SNTELTEDCE IKHLGQSLDC
360 370 380 390 400
NANVYMRPWE NKVIPTVKCQ ALDKTIPIRR RPPGFSPFRS AKVQETKAGT
410 420 430 440 450
TKQLPRNVLG AHGSQLAGRI QTQKQQNFLI LISLMFFLNL HSLGSFTNVL
460
PAFLSTAQAQ TL
Length:462
Mass (Da):51,052
Last modified:July 5, 2004 - v1
Checksum:i2A921AB50741C1DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154540 Genomic DNA. No translation available.
CT027991 Genomic DNA. No translation available.
BC139720 mRNA. Translation: AAI39721.1.
AY462057 mRNA. Translation: AAR88631.1.
RefSeqiNP_001095879.1. NM_001102409.1.
NP_001095880.1. NM_001102410.1.
NP_958763.1. NM_201375.2.
UniGeneiMm.440414.

Genome annotation databases

EnsembliENSMUST00000039338; ENSMUSP00000046867; ENSMUSG00000060459.
GeneIDi385643.
KEGGimmu:385643.
UCSCiuc007ysy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154540 Genomic DNA. No translation available.
CT027991 Genomic DNA. No translation available.
BC139720 mRNA. Translation: AAI39721.1.
AY462057 mRNA. Translation: AAR88631.1.
RefSeqiNP_001095879.1. NM_001102409.1.
NP_001095880.1. NM_001102410.1.
NP_958763.1. NM_201375.2.
UniGeneiMm.440414.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097623.

Protein family/group databases

MEROPSiI25.019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039338; ENSMUSP00000046867; ENSMUSG00000060459.
GeneIDi385643.
KEGGimmu:385643.
UCSCiuc007ysy.1. mouse.

Organism-specific databases

CTDi385643.
MGIiMGI:3027157. Kng2.

Phylogenomic databases

eggNOGiENOG410IKIQ. Eukaryota.
ENOG4111ZQ8. LUCA.
GeneTreeiENSGT00440000039713.
HOGENOMiHOG000113239.
HOVERGENiHBG006224.
KOiK03898.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiKng2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060459.

Family and domain databases

InterProiIPR000010. Cystatin_dom.
IPR027358. Kininogen-type_cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PfamiPF00031. Cystatin. 3 hits.
[Graphical view]
SMARTiSM00043. CY. 3 hits.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
PS51647. CYSTATIN_KININOGEN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6S9I2_MOUSE
AccessioniPrimary (citable) accession number: Q6S9I2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.