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Protein
Submitted name:

HMW-kininogen-II variant

Gene

Kng2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitorPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-375276 Peptide ligand-binding receptors
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Submitted name:
HMW-kininogen-II variantImported
Submitted name:
Kininogen 2Imported
Submitted name:
Kng2 proteinImported
Gene namesi
Name:Kng2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:3027157 Kng2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501458747824 – 462Sequence analysisAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 96PROSITE-ProRule annotation
Disulfide bondi83 ↔ 94PROSITE-ProRule annotation
Disulfide bondi228 ↔ 247PROSITE-ProRule annotation
Disulfide bondi350 ↔ 369PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000060459

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 131Cystatin kininogen-typeInterPro annotationAdd BLAST104
Domaini150 – 253Cystatin kininogen-typeInterPro annotationAdd BLAST104
Domaini272 – 375Cystatin kininogen-typeInterPro annotationAdd BLAST104

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IKIQ Eukaryota
ENOG4111ZQ8 LUCA
GeneTreeiENSGT00440000039713
HOGENOMiHOG000113239
HOVERGENiHBG006224
KOiK03898

Family and domain databases

CDDicd00042 CY, 3 hits
InterProiView protein in InterPro
IPR000010 Cystatin_dom
IPR027358 Kininogen-type_cystatin_dom
IPR018073 Prot_inh_cystat_CS
PfamiView protein in Pfam
PF00031 Cystatin, 3 hits
SMARTiView protein in SMART
SM00043 CY, 3 hits
PROSITEiView protein in PROSITE
PS00287 CYSTATIN, 1 hit
PS51647 CYSTATIN_KININOGEN, 3 hits

Sequencei

Sequence statusi: Complete.

Q6S9I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLITTLLLC SGLLLTLTQG EEAQEIDCND EAVFQAVDAS LKKLNARLQS
60 70 80 90 100
GNQFVLYRVT KRAKMDGSAT FYSFNYQIKE GNCSAQRGLA WQDCDFKDSE
110 120 130 140 150
EAATGECTAT MGKKENKFFI VTQTCKITPG KGPIVTEEYH CASCVHPISA
160 170 180 190 200
DNPDLEPVLK HAIEYFNNNT GHSHLFALRE VKSAQGQVVG GLNFDIIYTI
210 220 230 240 250
VQTNCSKERF PSLRGDCVAL PNGDGGECRG NAFLDTDNKI EDFTQSCDLH
260 270 280 290 300
PGDDLVEALP KPCPGCPRDI PVDSPELKEV LGHSIAQLNT ENDHPFYFKI
310 320 330 340 350
DTVKKATSQV VAGTNYVIEF IARETKCSKE SNTELTEDCE IKHLGQSLDC
360 370 380 390 400
NANVYMRPWE NKVIPTVKCQ ALDKTIPIRR RPPGFSPFRS AKVQETKAGT
410 420 430 440 450
TKQLPRNVLG AHGSQLAGRI QTQKQQNFLI LISLMFFLNL HSLGSFTNVL
460
PAFLSTAQAQ TL
Length:462
Mass (Da):51,052
Last modified:July 5, 2004 - v1
Checksum:i2A921AB50741C1DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154540 Genomic DNA No translation available.
CT027991 Genomic DNA No translation available.
BC139720 mRNA Translation: AAI39721.1
AY462057 mRNA Translation: AAR88631.1
RefSeqiNP_001095879.1, NM_001102409.1
NP_001095880.1, NM_001102410.1
NP_958763.1, NM_201375.2
UniGeneiMm.440414

Genome annotation databases

EnsembliENSMUST00000039338; ENSMUSP00000046867; ENSMUSG00000060459
GeneIDi385643
KEGGimmu:385643
UCSCiuc007ysy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ6S9I2_MOUSE
AccessioniPrimary (citable) accession number: Q6S9I2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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