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Protein
Submitted name:

Kininogen 2

Gene

Kng2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitorPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-MMU-375276. Peptide ligand-binding receptors.
R-MMU-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-8957275. Post-translational protein phosphorylation.

Names & Taxonomyi

Protein namesi
Submitted name:
Kininogen 2Imported
Submitted name:
Kng2 proteinImported
Submitted name:
LMW kininogen-IIImported
Submitted name:
MCG128256, isoform CRA_eImported
Gene namesi
Name:Kng2Imported
ORF Names:mCG_128256Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:3027157. Kng2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501050713424 – 433Sequence analysisAdd BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 96PROSITE-ProRule annotation
Disulfide bondi83 ↔ 94PROSITE-ProRule annotation
Disulfide bondi228 ↔ 247PROSITE-ProRule annotation
Disulfide bondi350 ↔ 369PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000060459.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097623.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 131Cystatin kininogen-typeInterPro annotationAdd BLAST104
Domaini150 – 253Cystatin kininogen-typeInterPro annotationAdd BLAST104
Domaini272 – 375Cystatin kininogen-typeInterPro annotationAdd BLAST104

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IKIQ. Eukaryota.
ENOG4111ZQ8. LUCA.
GeneTreeiENSGT00440000039713.
HOGENOMiHOG000113239.
HOVERGENiHBG006224.
KOiK03898.

Family and domain databases

CDDicd00042. CY. 3 hits.
InterProiView protein in InterPro
IPR000010. Cystatin_dom.
IPR027358. Kininogen-type_cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
PfamiView protein in Pfam
PF00031. Cystatin. 3 hits.
SMARTiView protein in SMART
SM00043. CY. 3 hits.
PROSITEiView protein in PROSITE
PS00287. CYSTATIN. 1 hit.
PS51647. CYSTATIN_KININOGEN. 3 hits.

Sequencei

Sequence statusi: Complete.

Q6S9I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLITTLLLC SGLLLTLTQG EEAQEIDCND EAVFQAVDAS LKKLNARLQS
60 70 80 90 100
GNQFVLYRVT KRAKMDGSAT FYSFNYQIKE GNCSAQRGLA WQDCDFKDSE
110 120 130 140 150
EAATGECTAT MGKKENKFFI VTQTCKITPG KGPIVTEEYH CASCVHPISA
160 170 180 190 200
DNPDLEPVLK HAIEYFNNNT GHSHLFALRE VKSAQGQVVG GLNFDIIYTI
210 220 230 240 250
VQTNCSKERF PSLRGDCVAL PNGDGGECRG NAFLDTDNKI EDFTQSCDLH
260 270 280 290 300
PGDDLVEALP KPCPGCPRDI PVDSPELKEV LGHSIAQLNT ENDHPFYFKI
310 320 330 340 350
DTVKKATSQV VAGTNYVIEF IARETKCSKE SNTELTEDCE IKHLGQSLDC
360 370 380 390 400
NANVYMRPWE NKVIPTVKCQ ALDKTIPIRR RPPGFSPFRS AKVQETKAGT
410 420 430
TRLLRACEYK GRLSKAGAEP APERQAESSQ VKQ
Length:433
Mass (Da):47,887
Last modified:July 5, 2004 - v1
Checksum:iC86F7BE91C7FE9C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154540 Genomic DNA. No translation available.
CT027991 Genomic DNA. No translation available.
BC108335 mRNA. Translation: AAI08336.1.
AY462059 mRNA. Translation: AAR88633.1.
CH466521 Genomic DNA. Translation: EDK97650.1.
RefSeqiNP_001095879.1. NM_001102409.1.
UniGeneiMm.440414.

Genome annotation databases

EnsembliENSMUST00000115349; ENSMUSP00000111006; ENSMUSG00000060459.
GeneIDi385643.
KEGGimmu:385643.
UCSCiuc007ysx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154540 Genomic DNA. No translation available.
CT027991 Genomic DNA. No translation available.
BC108335 mRNA. Translation: AAI08336.1.
AY462059 mRNA. Translation: AAR88633.1.
CH466521 Genomic DNA. Translation: EDK97650.1.
RefSeqiNP_001095879.1. NM_001102409.1.
UniGeneiMm.440414.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097623.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115349; ENSMUSP00000111006; ENSMUSG00000060459.
GeneIDi385643.
KEGGimmu:385643.
UCSCiuc007ysx.1. mouse.

Organism-specific databases

CTDi385643.
MGIiMGI:3027157. Kng2.

Phylogenomic databases

eggNOGiENOG410IKIQ. Eukaryota.
ENOG4111ZQ8. LUCA.
GeneTreeiENSGT00440000039713.
HOGENOMiHOG000113239.
HOVERGENiHBG006224.
KOiK03898.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-MMU-375276. Peptide ligand-binding receptors.
R-MMU-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-8957275. Post-translational protein phosphorylation.

Miscellaneous databases

ChiTaRSiKng2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060459.

Family and domain databases

CDDicd00042. CY. 3 hits.
InterProiView protein in InterPro
IPR000010. Cystatin_dom.
IPR027358. Kininogen-type_cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
PfamiView protein in Pfam
PF00031. Cystatin. 3 hits.
SMARTiView protein in SMART
SM00043. CY. 3 hits.
PROSITEiView protein in PROSITE
PS00287. CYSTATIN. 1 hit.
PS51647. CYSTATIN_KININOGEN. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6S9I0_MOUSE
AccessioniPrimary (citable) accession number: Q6S9I0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.