ID   POTEA_HUMAN             Reviewed;         498 AA.
AC   Q6S8J7; A6ND17; A6ND71; Q6S8J6;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 131.
DE   RecName: Full=POTE ankyrin domain family member A;
DE   AltName: Full=ANKRD26-like family A member 1;
DE   AltName: Full=Prostate, ovary, testis-expressed protein on chromosome 8;
DE            Short=POTE-8;
GN   Name=POTEA; Synonyms=A26A1, POTE8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Prostate;
RX   PubMed=15276201; DOI=10.1016/j.gene.2004.05.009;
RA   Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.;
RT   "Five POTE paralogs and their splice variants are expressed in human
RT   prostate and encode proteins of different lengths.";
RL   Gene 337:45-53(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=A;
CC         IsoId=Q6S8J7-1; Sequence=Displayed;
CC       Name=2; Synonyms=B;
CC         IsoId=Q6S8J7-2; Sequence=VSP_011974;
CC   -!- SIMILARITY: Belongs to the POTE family. {ECO:0000305}.
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DR   EMBL; AY462869; AAS58863.1; -; mRNA.
DR   EMBL; AY462870; AAS58864.1; -; mRNA.
DR   EMBL; AC022616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001002920.1; NM_001002920.1. [Q6S8J7-2]
DR   RefSeq; NP_001005365.2; NM_001005365.2. [Q6S8J7-1]
DR   AlphaFoldDB; Q6S8J7; -.
DR   SMR; Q6S8J7; -.
DR   BioGRID; 131050; 5.
DR   IntAct; Q6S8J7; 1.
DR   iPTMnet; Q6S8J7; -.
DR   PhosphoSitePlus; Q6S8J7; -.
DR   BioMuta; POTEA; -.
DR   DMDM; 55976446; -.
DR   jPOST; Q6S8J7; -.
DR   MassIVE; Q6S8J7; -.
DR   MaxQB; Q6S8J7; -.
DR   PeptideAtlas; Q6S8J7; -.
DR   ProteomicsDB; 67350; -. [Q6S8J7-1]
DR   ProteomicsDB; 67351; -. [Q6S8J7-2]
DR   DNASU; 340441; -.
DR   GeneID; 340441; -.
DR   KEGG; hsa:340441; -.
DR   AGR; HGNC:33893; -.
DR   CTD; 340441; -.
DR   DisGeNET; 340441; -.
DR   GeneCards; POTEA; -.
DR   HGNC; HGNC:33893; POTEA.
DR   MIM; 608915; gene.
DR   neXtProt; NX_Q6S8J7; -.
DR   PharmGKB; PA164724701; -.
DR   InParanoid; Q6S8J7; -.
DR   OrthoDB; 4701940at2759; -.
DR   PhylomeDB; Q6S8J7; -.
DR   PathwayCommons; Q6S8J7; -.
DR   SignaLink; Q6S8J7; -.
DR   BioGRID-ORCS; 340441; 3 hits in 171 CRISPR screens.
DR   GenomeRNAi; 340441; -.
DR   Pharos; Q6S8J7; Tdark.
DR   PRO; PR:Q6S8J7; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q6S8J7; Protein.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24147; ANKYRIN REPEAT DOMAIN 36-RELATED; 1.
DR   PANTHER; PTHR24147:SF68; POTE ANKYRIN DOMAIN FAMILY MEMBER A; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ANK repeat; Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..498
FT                   /note="POTE ankyrin domain family member A"
FT                   /id="PRO_0000066915"
FT   REPEAT          98..127
FT                   /note="ANK 1"
FT   REPEAT          131..160
FT                   /note="ANK 2"
FT   REPEAT          164..193
FT                   /note="ANK 3"
FT   REPEAT          197..226
FT                   /note="ANK 4"
FT   REPEAT          230..259
FT                   /note="ANK 5"
FT   REGION          289..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          469..497
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        289..304
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..347
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..410
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         233..278
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15276201"
FT                   /id="VSP_011974"
SQ   SEQUENCE   498 AA;  56166 MW;  758C1C7BD6F10395 CRC64;
     MVAEVSPKLA ASPMKKPFGF RGKMGKWCCC CFPCCRGSGK NNMGAWRDHD DSAFTEPRYH
     VRREDLGKLH RAAWWGEVPR ADLIVMLRGP GINKRDKKKR TALHLACANG NSEVVSLLLD
     RQCQLHVFDS KKRTALIKAV QCQEDECALM LLQHGTDPNL PDMYGNTALH YAVYNEDKLM
     AKTLLLYGAD IESKNKGGLT PLLLAVHGQK QRMVKFLIKK KANLNALDRF GRTALILAVR
     CGSASIVSLL LQQNIDVFSQ DVFGQTAEDY AVSSHHSIIC QLLSDYKENQ MPNNSSGNSN
     PEQDLKLTSE EEPQRLKGSE NSQHEKVTQE PDINKDCDRE VEEEMQKHGS NNVGLSENLT
     DGAAAGNGDG GLVPQRKSRK HENQQFPNTE IEEYHRPEKK SNEKNKVKSQ IHSVDNLDDI
     TWPSEIASED YDLLFSNYET FTLLIEQLKM DFNDSASLSK IQDAVISEEH LLELKNSHYE
     QLTVEVEQME NMVHVLQK
//