Q6S8J7 (POTEA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
POTE ankyrin domain family member A

Alternative name(s):
ANKRD26-like family A member 1
Prostate, ovary, testis-expressed protein on chromosome 8
Short name=POTE-8

Gene names

Name:	POTEA
Synonyms:	A26A1, POTE8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the POTE family. Contains 5 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6S8J7-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6S8J7-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     233-278: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	POTE ankyrin domain family member A		PRO_0000066915
Regions
	Repeat	98 – 127	30	ANK 1
	Repeat	131 – 160	30	ANK 2
	Repeat	164 – 193	30	ANK 3
	Repeat	197 – 226	30	ANK 4
	Repeat	230 – 259	30	ANK 5
	Coiled coil	469 – 497	29	Potential
	Compositional bias	28 – 35	8	Cys-rich
Natural variations
	Alternative sequence	233 – 278	46	Missing in isoform 2.		VSP_011974

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 758C1C7BD6F10395	FASTA	498	56,166
	10 20 30 40 50 60 MVAEVSPKLA ASPMKKPFGF RGKMGKWCCC CFPCCRGSGK NNMGAWRDHD DSAFTEPRYH 70 80 90 100 110 120 VRREDLGKLH RAAWWGEVPR ADLIVMLRGP GINKRDKKKR TALHLACANG NSEVVSLLLD 130 140 150 160 170 180 RQCQLHVFDS KKRTALIKAV QCQEDECALM LLQHGTDPNL PDMYGNTALH YAVYNEDKLM 190 200 210 220 230 240 AKTLLLYGAD IESKNKGGLT PLLLAVHGQK QRMVKFLIKK KANLNALDRF GRTALILAVR 250 260 270 280 290 300 CGSASIVSLL LQQNIDVFSQ DVFGQTAEDY AVSSHHSIIC QLLSDYKENQ MPNNSSGNSN 310 320 330 340 350 360 PEQDLKLTSE EEPQRLKGSE NSQHEKVTQE PDINKDCDRE VEEEMQKHGS NNVGLSENLT 370 380 390 400 410 420 DGAAAGNGDG GLVPQRKSRK HENQQFPNTE IEEYHRPEKK SNEKNKVKSQ IHSVDNLDDI 430 440 450 460 470 480 TWPSEIASED YDLLFSNYET FTLLIEQLKM DFNDSASLSK IQDAVISEEH LLELKNSHYE 490 QLTVEVEQME NMVHVLQK
	Isoform 2 (B) [UniParc]. Checksum: 498C03F7E9278F8E	FASTA	452	51,278
	10 20 30 40 50 60 MVAEVSPKLA ASPMKKPFGF RGKMGKWCCC CFPCCRGSGK NNMGAWRDHD DSAFTEPRYH 70 80 90 100 110 120 VRREDLGKLH RAAWWGEVPR ADLIVMLRGP GINKRDKKKR TALHLACANG NSEVVSLLLD 130 140 150 160 170 180 RQCQLHVFDS KKRTALIKAV QCQEDECALM LLQHGTDPNL PDMYGNTALH YAVYNEDKLM 190 200 210 220 230 240 AKTLLLYGAD IESKNKGGLT PLLLAVHGQK QRMVKFLIKK KANLNALDRF GRICQLLSDY 250 260 270 280 290 300 KENQMPNNSS GNSNPEQDLK LTSEEEPQRL KGSENSQHEK VTQEPDINKD CDREVEEEMQ 310 320 330 340 350 360 KHGSNNVGLS ENLTDGAAAG NGDGGLVPQR KSRKHENQQF PNTEIEEYHR PEKKSNEKNK 370 380 390 400 410 420 VKSQIHSVDN LDDITWPSEI ASEDYDLLFS NYETFTLLIE QLKMDFNDSA SLSKIQDAVI 430 440 450 SEEHLLELKN SHYEQLTVEV EQMENMVHVL QK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths." Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I. Gene 337:45-53(2004) [PubMed: 15276201] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Prostate.
[2]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY462869 mRNA. Translation: AAS58863.1. AY462870 mRNA. Translation: AAS58864.1. AC022616 Genomic DNA. No translation available.
IPI	IPI00470364. IPI00478326.
RefSeq	NP_001002920.1. NM_001002920.1. NP_001005365.2. NM_001005365.2.
UniGene	Hs.531579.
3D structure databases
ProteinModelPortal	Q6S8J7.
SMR	Q6S8J7. Positions 64-289.
ModBase	Search...
Polymorphism databases
DMDM	55976446.
Proteomic databases
PRIDE	Q6S8J7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354247; ENSP00000346193; ENSG00000188877.
GeneID	340441.
KEGG	hsa:340441.
UCSC	uc003xpz.1. human. uc003xqa.1. human.
Organism-specific databases
CTD	340441.
GeneCards	GC08P043147.
H-InvDB	HIX0034320.
HGNC	HGNC:33893. POTEA.
MIM	608915. gene.
neXtProt	NX_Q6S8J7.
PharmGKB	PA164724701.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17475.
GeneTree	ENSGT00560000076605.
HOGENOM	HBG505546.
InParanoid	Q6S8J7.
OMA	CANGNSE.
OrthoDB	EOG4NVZK6.
PhylomeDB	Q6S8J7.
Gene expression databases
ArrayExpress	Q6S8J7.
CleanEx	HS_POTEA.
Genevestigator	Q6S8J7.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF12796. Ank_2. 3 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 6 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	97861.
SOURCE	Search...

Entry information

Entry name

POTEA_HUMAN

Accession

Primary (citable) accession number: Q6S8J7
Secondary accession number(s): A6ND17, A6ND71, Q6S8J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.