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Q6S8J7 (POTEA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POTE ankyrin domain family member A
Alternative name(s):
ANKRD26-like family A member 1
Prostate, ovary, testis-expressed protein on chromosome 8
Short name=POTE-8
Gene names
Name:POTEA
Synonyms:A26A1, POTE8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the POTE family.

Contains 5 ANK repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Coiled coil
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6S8J7-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6S8J7-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     233-278: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498POTE ankyrin domain family member A
PRO_0000066915

Regions

Repeat98 – 12730ANK 1
Repeat131 – 16030ANK 2
Repeat164 – 19330ANK 3
Repeat197 – 22630ANK 4
Repeat230 – 25930ANK 5
Coiled coil469 – 49729 Potential
Compositional bias28 – 358Cys-rich

Natural variations

Alternative sequence233 – 27846Missing in isoform 2.
VSP_011974

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 758C1C7BD6F10395

FASTA49856,166
        10         20         30         40         50         60 
MVAEVSPKLA ASPMKKPFGF RGKMGKWCCC CFPCCRGSGK NNMGAWRDHD DSAFTEPRYH 

        70         80         90        100        110        120 
VRREDLGKLH RAAWWGEVPR ADLIVMLRGP GINKRDKKKR TALHLACANG NSEVVSLLLD 

       130        140        150        160        170        180 
RQCQLHVFDS KKRTALIKAV QCQEDECALM LLQHGTDPNL PDMYGNTALH YAVYNEDKLM 

       190        200        210        220        230        240 
AKTLLLYGAD IESKNKGGLT PLLLAVHGQK QRMVKFLIKK KANLNALDRF GRTALILAVR 

       250        260        270        280        290        300 
CGSASIVSLL LQQNIDVFSQ DVFGQTAEDY AVSSHHSIIC QLLSDYKENQ MPNNSSGNSN 

       310        320        330        340        350        360 
PEQDLKLTSE EEPQRLKGSE NSQHEKVTQE PDINKDCDRE VEEEMQKHGS NNVGLSENLT 

       370        380        390        400        410        420 
DGAAAGNGDG GLVPQRKSRK HENQQFPNTE IEEYHRPEKK SNEKNKVKSQ IHSVDNLDDI 

       430        440        450        460        470        480 
TWPSEIASED YDLLFSNYET FTLLIEQLKM DFNDSASLSK IQDAVISEEH LLELKNSHYE 

       490 
QLTVEVEQME NMVHVLQK 

« Hide

Isoform 2 (B) [UniParc].

Checksum: 498C03F7E9278F8E
Show »

FASTA45251,278

References

« Hide 'large scale' references
[1]"Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths."
Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.
Gene 337:45-53(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Prostate.
[2]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY462869 mRNA. Translation: AAS58863.1.
AY462870 mRNA. Translation: AAS58864.1.
AC022616 Genomic DNA. No translation available.
RefSeqNP_001002920.1. NM_001002920.1.
NP_001005365.2. NM_001005365.2.
UniGeneHs.531579.

3D structure databases

ProteinModelPortalQ6S8J7.
SMRQ6S8J7. Positions 69-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000346193.

PTM databases

PhosphoSiteQ6S8J7.

Polymorphism databases

DMDM55976446.

Proteomic databases

PaxDbQ6S8J7.
PRIDEQ6S8J7.

Protocols and materials databases

DNASU340441.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID340441.
KEGGhsa:340441.
UCSCuc003xpz.1. human. [Q6S8J7-1]
uc003xqa.1. human. [Q6S8J7-2]

Organism-specific databases

CTD340441.
GeneCardsGC08P043147.
HGNCHGNC:33893. POTEA.
HPAHPA042822.
MIM608915. gene.
neXtProtNX_Q6S8J7.
PharmGKBPA164724701.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOGENOMHOG000293138.
InParanoidQ6S8J7.
KOK17299.
PhylomeDBQ6S8J7.

Gene expression databases

CleanExHS_POTEA.
GenevestigatorQ6S8J7.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF12796. Ank_2. 3 hits.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi340441.
NextBio97861.
PROQ6S8J7.
SOURCESearch...

Entry information

Entry namePOTEA_HUMAN
AccessionPrimary (citable) accession number: Q6S8J7
Secondary accession number(s): A6ND17, A6ND71, Q6S8J6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM