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Protein

POTE ankyrin domain family member E

Gene

POTEE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • retina homeostasis Source: UniProtKB
  • substantia nigra development Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ6S8J3.

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member E
Alternative name(s):
ANKRD26-like family C member 1A
Prostate, ovary, testis-expressed protein on chromosome 2
Short name:
POTE-2
Gene namesi
Name:POTEE
Synonyms:A26C1A, POTE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33895. POTEE.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724783.

Polymorphism and mutation databases

BioMutaiPOTEE.
DMDMi166898073.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10751075POTE ankyrin domain family member EPRO_0000066914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki684 – 684Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ6S8J3.
MaxQBiQ6S8J3.
PaxDbiQ6S8J3.
PRIDEiQ6S8J3.
TopDownProteomicsiQ6S8J3-1. [Q6S8J3-1]

PTM databases

iPTMnetiQ6S8J3.
PhosphoSiteiQ6S8J3.
SwissPalmiQ6S8J3.

Expressioni

Gene expression databases

BgeeiQ6S8J3.
CleanExiHS_POTEE.
ExpressionAtlasiQ6S8J3. baseline and differential.

Organism-specific databases

HPAiHPA041264.
HPA041271.
HPA042822.
HPA043260.

Interactioni

Protein-protein interaction databases

BioGridi138656. 26 interactions.
IntActiQ6S8J3. 3 interactions.
STRINGi9606.ENSP00000439189.

Structurei

3D structure databases

ProteinModelPortaliQ6S8J3.
SMRiQ6S8J3. Positions 143-388, 706-1075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati172 – 20130ANK 1Add
BLAST
Repeati205 – 23430ANK 2Add
BLAST
Repeati238 – 26730ANK 3Add
BLAST
Repeati271 – 30030ANK 4Add
BLAST
Repeati304 – 33330ANK 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni702 – 1075374Actin-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili399 – 43537Sequence analysisAdd
BLAST
Coiled coili642 – 69857Sequence analysisAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the POTE family.Curated
In the C-terminal section; belongs to the actin family.Curated
Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
KOG0676. Eukaryota.
COG0666. LUCA.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000115614.
InParanoidiQ6S8J3.
KOiK17299.
OMAiLENCMAI.
PhylomeDBiQ6S8J3.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00022. Actin. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
SM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6S8J3-1) [UniParc]FASTAAdd to basket

Also known as: POTE2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVEVDSMPA ASSVKKPFGL RSKMGKWCCR CFPCYRESGK SNVGTSGDHD
60 70 80 90 100
DSAMKTLRSK MGKWCHHCFP CCRGSGKSNV GASGDHDDSA MKTLRNKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSKVGAW GDYDDSAFME PRYHVRGEDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDVNKKD KQKRTALHLA SANGNSEVVK LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAVQCQEDE CALMLLEHGT DPNIPDEYGN TTLHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICQLLSDY KEKQMLKISS ENSNPEQELK LTSEEESQRF KGSENSQPEK
410 420 430 440 450
MSQELEINKD GDREVEEEMK KHESNNVGLL ENLTNGVTAG NGDNGLIPQR
460 470 480 490 500
KSRTPENQQF PDNESEEYHR ICELLSDYKE KQMPKYSSEN SNPEQDLKLT
510 520 530 540 550
SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE EMKKHGSTHV
560 570 580 590 600
GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ
610 620 630 640 650
KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDVLHENST
660 670 680 690 700
LREEIAMLRL ELDTMKHQSQ LREKKYLEDI ESVKKKNDNL LKALQLNELT
710 720 730 740 750
MDDDTAVLVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK
760 770 780 790 800
ESYVGKEAQS KRGILTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE
810 820 830 840 850
HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVP SLYTSGRTTG
860 870 880 890 900
IVMDSGDGVT HTVPIYEGNA LPHATLRLDL AGRELPDYLM KILTERGYRF
910 920 930 940 950
TTMAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI
960 970 980 990 1000
GNERFRCPEA LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS
1010 1020 1030 1040 1050
GGTTMYPGMA HRMQKEIAAL APSMMKIRII APPKRKYSVW VGGSILASLS
1060 1070
TFQQMWISKQ EYDESGPSIV HRKCF
Length:1,075
Mass (Da):121,363
Last modified:February 5, 2008 - v3
Checksum:i581F842CDDC13EFC
GO
Isoform 2 (identifier: Q6S8J3-2) [UniParc]FASTAAdd to basket

Also known as: POTE2B

The sequence of this isoform differs from the canonical sequence as follows:
     212-212: K → KVCSSQLYQHE
     377-384: QELKLTSE → NVSRTRNK
     385-1075: Missing.

Show »
Length:394
Mass (Da):44,113
Checksum:i58C1E27852BD4DA4
GO
Isoform 3 (identifier: Q6S8J3-3) [UniParc]FASTAAdd to basket

Also known as: POTE2C, POTE2D

The sequence of this isoform differs from the canonical sequence as follows:
     376-376: E → G
     377-1075: Missing.

Show »
Length:376
Mass (Da):41,909
Checksum:i7804E08803E5A577
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti346 – 3461V → G in AAS58867 (PubMed:15276201).Curated
Sequence conflicti378 – 3781E → D in AAS58865 (PubMed:15276201).Curated
Sequence conflicti546 – 5461G → R in AAS58865 (PubMed:15276201).Curated
Sequence conflicti563 – 5631G → A in AAS58865 (PubMed:15276201).Curated
Sequence conflicti578 – 5781P → L in AAS58865 (PubMed:15276201).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei212 – 2121K → KVCSSQLYQHE in isoform 2. 1 PublicationVSP_011969
Alternative sequencei376 – 3761E → G in isoform 3. 1 PublicationVSP_011970
Alternative sequencei377 – 1075699Missing in isoform 3. 1 PublicationVSP_011971Add
BLAST
Alternative sequencei377 – 3848QELKLTSE → NVSRTRNK in isoform 2. 1 PublicationVSP_011972
Alternative sequencei385 – 1075691Missing in isoform 2. 1 PublicationVSP_011973Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131180 Genomic DNA. No translation available.
AY462868 mRNA. Translation: AAS58862.1.
AY462871 mRNA. Translation: AAS58865.1.
AY462872 mRNA. Translation: AAS58866.1.
AY462873 mRNA. Translation: AAS58867.1.
CCDSiCCDS46414.1. [Q6S8J3-1]
RefSeqiNP_001077007.1. NM_001083538.1. [Q6S8J3-1]
UniGeneiHs.686146.

Genome annotation databases

EnsembliENST00000356920; ENSP00000439189; ENSG00000188219. [Q6S8J3-1]
ENST00000358087; ENSP00000443049; ENSG00000188219. [Q6S8J3-2]
ENST00000514256; ENSP00000477649; ENSG00000188219. [Q6S8J3-3]
ENST00000626191; ENSP00000485683; ENSG00000188219. [Q6S8J3-3]
GeneIDi445582.
KEGGihsa:445582.
UCSCiuc002tsn.3. human. [Q6S8J3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131180 Genomic DNA. No translation available.
AY462868 mRNA. Translation: AAS58862.1.
AY462871 mRNA. Translation: AAS58865.1.
AY462872 mRNA. Translation: AAS58866.1.
AY462873 mRNA. Translation: AAS58867.1.
CCDSiCCDS46414.1. [Q6S8J3-1]
RefSeqiNP_001077007.1. NM_001083538.1. [Q6S8J3-1]
UniGeneiHs.686146.

3D structure databases

ProteinModelPortaliQ6S8J3.
SMRiQ6S8J3. Positions 143-388, 706-1075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138656. 26 interactions.
IntActiQ6S8J3. 3 interactions.
STRINGi9606.ENSP00000439189.

PTM databases

iPTMnetiQ6S8J3.
PhosphoSiteiQ6S8J3.
SwissPalmiQ6S8J3.

Polymorphism and mutation databases

BioMutaiPOTEE.
DMDMi166898073.

Proteomic databases

EPDiQ6S8J3.
MaxQBiQ6S8J3.
PaxDbiQ6S8J3.
PRIDEiQ6S8J3.
TopDownProteomicsiQ6S8J3-1. [Q6S8J3-1]

Protocols and materials databases

DNASUi445582.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356920; ENSP00000439189; ENSG00000188219. [Q6S8J3-1]
ENST00000358087; ENSP00000443049; ENSG00000188219. [Q6S8J3-2]
ENST00000514256; ENSP00000477649; ENSG00000188219. [Q6S8J3-3]
ENST00000626191; ENSP00000485683; ENSG00000188219. [Q6S8J3-3]
GeneIDi445582.
KEGGihsa:445582.
UCSCiuc002tsn.3. human. [Q6S8J3-1]

Organism-specific databases

CTDi445582.
GeneCardsiPOTEE.
H-InvDBHIX0024222.
HIX0029907.
HGNCiHGNC:33895. POTEE.
HPAiHPA041264.
HPA041271.
HPA042822.
HPA043260.
MIMi608914. gene.
neXtProtiNX_Q6S8J3.
PharmGKBiPA164724783.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
KOG0676. Eukaryota.
COG0666. LUCA.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000115614.
InParanoidiQ6S8J3.
KOiK17299.
OMAiLENCMAI.
PhylomeDBiQ6S8J3.

Enzyme and pathway databases

SignaLinkiQ6S8J3.

Miscellaneous databases

GenomeRNAii445582.
PROiQ6S8J3.
SOURCEiSearch...

Gene expression databases

BgeeiQ6S8J3.
CleanExiHS_POTEE.
ExpressionAtlasiQ6S8J3. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00022. Actin. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
SM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths."
    Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.
    Gene 337:45-53(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-712 (ISOFORMS 1; 2 AND 3).
    Tissue: Prostate.
  3. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-684.
    Tissue: Mammary cancer.

Entry informationi

Entry nameiPOTEE_HUMAN
AccessioniPrimary (citable) accession number: Q6S8J3
Secondary accession number(s): Q6S8J4, Q6S8J5, Q6S8J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: February 5, 2008
Last modified: June 8, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.