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Protein
Submitted name:

Parkin

Gene

PARK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: Ensembl

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. cellular protein catabolic process Source: Ensembl
  3. cellular response to toxic substance Source: Ensembl
  4. dopamine metabolic process Source: Ensembl
  5. dopamine uptake involved in synaptic transmission Source: Ensembl
  6. learning Source: Ensembl
  7. negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway Source: Ensembl
  8. norepinephrine metabolic process Source: Ensembl
  9. positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Source: Ensembl
  10. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  11. positive regulation of protein linear polyubiquitination Source: Ensembl
  12. protein localization to mitochondrion Source: Ensembl
  13. regulation of neurotransmitter secretion Source: Ensembl
  14. response to endoplasmic reticulum stress Source: Ensembl
  15. startle response Source: Ensembl
  16. synaptic transmission, glutamatergic Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ParkinImported
Gene namesi
Name:PARK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. neuron projection Source: Ensembl
  2. nucleus Source: Ensembl
  3. protein complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ6S8G7.
ExpressionAtlasiQ6S8G7. baseline and differential.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000013184.

Sequencei

Sequence statusi: Fragment.

Q6S8G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40
GRSIYNSFYV YCKGPCQRVQ PGKLRVQCST CRQATLTLTQ
Length:40
Mass (Da):4,555
Last modified:July 5, 2004 - v1
Checksum:i835B042FAB190D3F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei40 – 401Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY463003 Genomic DNA. Translation: AAR27057.1.
UniGeneiHs.132954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY463003 Genomic DNA. Translation: AAR27057.1.
UniGeneiHs.132954.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

H-InvDBHIX0023029.

Phylogenomic databases

HOGENOMiHOG000013184.

Gene expression databases

BgeeiQ6S8G7.
ExpressionAtlasiQ6S8G7. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "New polymorphism (IVS3-20 T-->C) of the parkin gene associated with the early-onset Parkinson's disease in Chinese."
    Zou H.Q., Chen B., Ma Q.L., Li X., Yang J.F., Feng X.L., Dong X.M., Li Y.J.
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:219-223(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6S8G7_HUMAN
AccessioniPrimary (citable) accession number: Q6S8G7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 4, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.