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Q6S5H5 (POTEG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POTE ankyrin domain family member G
Alternative name(s):
ANKRD26-like family C member 2
Prostate, ovary, testis-expressed protein on chromosome 14
Short name=POTE-14
Gene names
Name:POTEG
Synonyms:A26C2, POTE14
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the POTE family.

Contains 5 ANK repeats.

Sequence caution

The sequence AAS58870.1 differs from that shown. Reason: Frameshift at position 308.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 3 (identifier: Q6S5H5-3)

Also known as: POTE14A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6S5H5-2)

Also known as: POTE14C;

The sequence of this isoform differs from the canonical sequence as follows:
     470-508: SDEQNDTQKQLSEEQNTGILQDEILIHEEKQIEVAENEF → RDFSGHPNFPTTLPIKQ
Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 1 (identifier: Q6S5H5-4)

Also known as: POTE14B;

The sequence of this isoform differs from the canonical sequence as follows:
     271-507: HGLTPLLLGV...EKQIEVAENE → IESHSVSQAG...LFIFIFIFIF
Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508POTE ankyrin domain family member G
PRO_0000066916

Regions

Repeat172 – 20130ANK 1
Repeat205 – 23430ANK 2
Repeat238 – 26730ANK 3
Repeat271 – 30030ANK 4
Repeat304 – 33330ANK 5

Natural variations

Alternative sequence271 – 507237HGLTP…VAENE → IESHSVSQAGVQWCDHSSLQ PRPPEAQMVLQPQPQLFFSF FLFIFIFIFIF in isoform 1.
VSP_040056
Alternative sequence470 – 50839SDEQN…AENEF → RDFSGHPNFPTTLPIKQ in isoform 2.
VSP_040057

Experimental info

Sequence conflict331P → A in AAS58870. Ref.1
Sequence conflict661R → C in AAS58870. Ref.1
Sequence conflict761S → G in AAS58870. Ref.1
Sequence conflict761S → G in AAS58871. Ref.1
Sequence conflict2011I → V in AAS58870. Ref.1
Sequence conflict2171R → Q in AAS58870. Ref.1
Sequence conflict2171R → Q in AAS58871. Ref.1
Sequence conflict2171R → Q in AAI27624. Ref.3
Sequence conflict2421A → T in AAS58871. Ref.1
Sequence conflict3491H → R in AAS58868. Ref.1
Sequence conflict3491H → R in AAS58871. Ref.1
Sequence conflict3651M → I in AAS58868. Ref.1
Sequence conflict3791L → S in AAI27624. Ref.3
Sequence conflict4341P → T in AAS58871. Ref.1
Sequence conflict4341P → T in AAI27624. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 3 (POTE14A) [UniParc].

Last modified November 30, 2010. Version 5.
Checksum: D7381307809863A3

FASTA50857,096
        10         20         30         40         50         60 
MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFPWCRGSGK SNVGTSGDHD DSAMKTLRSK 

        70         80         90        100        110        120 
MGKWCRHCFP WCRGSSKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSKVGPW 

       130        140        150        160        170        180 
GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LKDTDMNKKD KQKRTALHLA 

       190        200        210        220        230        240 
SANGNSEVVK LLLDRRCQLN ILDNKKRTAL TKAVQCREDE CALMLLEHGT DPNIPDEYGN 

       250        260        270        280        290        300 
TALHYAIYNE DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA 

       310        320        330        340        350        360 
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH NVICQLLSDY 

       370        380        390        400        410        420 
KEKQMLKVSS ENSNPEQDLK LTSEEESQRL KGSENSQPEE MSQEPEINKG GDRKVEEEMK 

       430        440        450        460        470        480 
KHGSTHMGFP ENLPNGATAD NGDDGLIPPR KSRTPESQQF PDTENEQYHS DEQNDTQKQL 

       490        500 
SEEQNTGILQ DEILIHEEKQ IEVAENEF

« Hide

Isoform 2 (POTE14C) [UniParc].

Checksum: B014BD5FAE7BDE65
Show »

FASTA48654,479
Isoform 1 (POTE14B) [UniParc].

Checksum: 8EC795CA46101912
Show »

FASTA32236,537

References

« Hide 'large scale' references
[1]"Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths."
Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.
Gene 337:45-53(2004) [PubMed: 15276201] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Prostate.
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed: 12508121] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-458 (ISOFORM 3).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY462874 mRNA. Translation: AAS58868.1.
AY465171 mRNA. Translation: AAS58870.1. Frameshift.
AY465172 mRNA. Translation: AAS58871.1.
AL512624 Genomic DNA. No translation available.
BC127623 mRNA. Translation: AAI27624.1.
IPIIPI00470333.
IPI00479176.
IPI00973188.
RefSeqNP_001005356.1. NM_001005356.2.
UniGeneHs.711826.

3D structure databases

ProteinModelPortalQ6S5H5.
SMRQ6S5H5. Positions 138-363.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6S5H5.

PTM databases

PhosphoSiteQ6S5H5.

Polymorphism databases

DMDM288558853.

Proteomic databases

PRIDEQ6S5H5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000439503; ENSP00000389253; ENSG00000187537.
GeneID404785.
KEGGhsa:404785.

Organism-specific databases

CTD404785.
GeneCardsGC14P019554.
H-InvDBHIX0037709.
HIX0041403.
HGNCHGNC:33896. POTEG.
MIM608916. gene.
neXtProtNX_Q6S5H5.
PharmGKBPA164724853.
GenAtlasSearch...

Phylogenomic databases

GeneTreeENSGT00560000076605.
HOGENOMHBG505546.
InParanoidQ6S5H5.
OMAEDQCALM.
OrthoDBEOG4V1714.
PhylomeDBQ6S5H5.

Gene expression databases

BgeeQ6S5H5.
CleanExHS_POTEG.
GenevestigatorQ6S5H5.

Family and domain databases

InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PfamPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMSSF48403. ANK. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio107944.
SOURCESearch...

Entry information

Entry namePOTEG_HUMAN
AccessionPrimary (citable) accession number: Q6S5H5
Secondary accession number(s): A1L153 expand/collapse secondary AC list , A6NMI9, Q6S5H6, Q6S8J2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 30, 2010
Last modified: December 14, 2011
This is version 74 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents