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Protein

POTE ankyrin domain family member G

Gene

POTEG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member G
Alternative name(s):
ANKRD26-like family C member 2
Prostate, ovary, testis-expressed protein on chromosome 14
Short name:
POTE-14
Gene namesi
Name:POTEG
Synonyms:A26C2, POTE14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:33896. POTEG.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724853.

Polymorphism and mutation databases

BioMutaiPOTEG.
DMDMi313104320.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508POTE ankyrin domain family member GPRO_0000066916Add
BLAST

Proteomic databases

PaxDbiQ6S5H5.
PeptideAtlasiQ6S5H5.
PRIDEiQ6S5H5.

PTM databases

iPTMnetiQ6S5H5.
PhosphoSiteiQ6S5H5.

Expressioni

Gene expression databases

BgeeiQ6S5H5.
CleanExiHS_POTEG.

Organism-specific databases

HPAiHPA042822.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386971.

Structurei

3D structure databases

ProteinModelPortaliQ6S5H5.
SMRiQ6S5H5. Positions 143-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati172 – 20130ANK 1Add
BLAST
Repeati205 – 23430ANK 2Add
BLAST
Repeati238 – 26730ANK 3Add
BLAST
Repeati271 – 30030ANK 4Add
BLAST
Repeati304 – 33330ANK 5Add
BLAST

Sequence similaritiesi

Belongs to the POTE family.Curated
Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000293138.
InParanoidiQ6S5H5.
KOiK17299.
OMAiDHDDSSM.
OrthoDBiEOG7FBRHS.
PhylomeDBiQ6S5H5.
TreeFamiTF337879.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q6S5H5-3) [UniParc]FASTAAdd to basket

Also known as: POTE14A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFPWCRGSGK SNVGTSGDHD
60 70 80 90 100
DSAMKTLRSK MGKWCRHCFP WCRGSSKSNV GTSGDHDDSA MKTLRSKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSKVGPW GDYDDSAFME PRYHVRREDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LKDTDMNKKD KQKRTALHLA SANGNSEVVK LLLDRRCQLN
210 220 230 240 250
ILDNKKRTAL TKAVQCREDE CALMLLEHGT DPNIPDEYGN TALHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
NVICQLLSDY KEKQMLKVSS ENSNPEQDLK LTSEEESQRL KGSENSQPEE
410 420 430 440 450
MSQEPEINKG GDRKVEEEMK KHGSTHMGFP ENLPNGATAD NGDDGLIPPR
460 470 480 490 500
KSRTPESQQF PDTENEQYHS DEQNDTQKQL SEEQNTGILQ DEILIHEEKQ

IEVAENEF
Length:508
Mass (Da):57,096
Last modified:November 30, 2010 - v5
Checksum:iD7381307809863A3
GO
Isoform 2 (identifier: Q6S5H5-2) [UniParc]FASTAAdd to basket

Also known as: POTE14C

The sequence of this isoform differs from the canonical sequence as follows:
     470-508: SDEQNDTQKQLSEEQNTGILQDEILIHEEKQIEVAENEF → RDFSGHPNFPTTLPIKQ

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:486
Mass (Da):54,479
Checksum:iB014BD5FAE7BDE65
GO
Isoform 1 (identifier: Q6S5H5-4) [UniParc]FASTAAdd to basket

Also known as: POTE14B

The sequence of this isoform differs from the canonical sequence as follows:
     271-507: HGLTPLLLGV...EKQIEVAENE → IESHSVSQAG...LFIFIFIFIF

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:322
Mass (Da):36,537
Checksum:i8EC795CA46101912
GO

Sequence cautioni

The sequence AAS58870.1 differs from that shown. Reason: Frameshift at position 308. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331P → A in AAS58870 (PubMed:15276201).Curated
Sequence conflicti66 – 661R → C in AAS58870 (PubMed:15276201).Curated
Sequence conflicti76 – 761S → G in AAS58870 (PubMed:15276201).Curated
Sequence conflicti76 – 761S → G in AAS58871 (PubMed:15276201).Curated
Sequence conflicti201 – 2011I → V in AAS58870 (PubMed:15276201).Curated
Sequence conflicti217 – 2171R → Q in AAS58870 (PubMed:15276201).Curated
Sequence conflicti217 – 2171R → Q in AAS58871 (PubMed:15276201).Curated
Sequence conflicti217 – 2171R → Q in AAI27624 (PubMed:15489334).Curated
Sequence conflicti242 – 2421A → T in AAS58871 (PubMed:15276201).Curated
Sequence conflicti349 – 3491H → R in AAS58868 (PubMed:15276201).Curated
Sequence conflicti349 – 3491H → R in AAS58871 (PubMed:15276201).Curated
Sequence conflicti365 – 3651M → I in AAS58868 (PubMed:15276201).Curated
Sequence conflicti379 – 3791L → S in AAI27624 (PubMed:15489334).Curated
Sequence conflicti434 – 4341P → T in AAS58871 (PubMed:15276201).Curated
Sequence conflicti434 – 4341P → T in AAI27624 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei271 – 507237HGLTP…VAENE → IESHSVSQAGVQWCDHSSLQ PRPPEAQMVLQPQPQLFFSF FLFIFIFIFIF in isoform 1. 1 PublicationVSP_040056Add
BLAST
Alternative sequencei470 – 50839SDEQN…AENEF → RDFSGHPNFPTTLPIKQ in isoform 2. 1 PublicationVSP_040057Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY462874 mRNA. Translation: AAS58868.1.
AY465171 mRNA. Translation: AAS58870.1. Frameshift.
AY465172 mRNA. Translation: AAS58871.1.
AL512624 Genomic DNA. No translation available.
BC127623 mRNA. Translation: AAI27624.1.
CCDSiCCDS73610.1. [Q6S5H5-3]
RefSeqiNP_001005356.1. NM_001005356.2. [Q6S5H5-3]
UniGeneiHs.711826.

Genome annotation databases

EnsembliENST00000547722; ENSP00000450807; ENSG00000187537. [Q6S5H5-4]
ENST00000547848; ENSP00000450853; ENSG00000187537. [Q6S5H5-3]
ENST00000622767; ENSP00000482662; ENSG00000187537. [Q6S5H5-2]
GeneIDi404785.
KEGGihsa:404785.
UCSCiuc001vuz.3. human. [Q6S5H5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY462874 mRNA. Translation: AAS58868.1.
AY465171 mRNA. Translation: AAS58870.1. Frameshift.
AY465172 mRNA. Translation: AAS58871.1.
AL512624 Genomic DNA. No translation available.
BC127623 mRNA. Translation: AAI27624.1.
CCDSiCCDS73610.1. [Q6S5H5-3]
RefSeqiNP_001005356.1. NM_001005356.2. [Q6S5H5-3]
UniGeneiHs.711826.

3D structure databases

ProteinModelPortaliQ6S5H5.
SMRiQ6S5H5. Positions 143-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386971.

PTM databases

iPTMnetiQ6S5H5.
PhosphoSiteiQ6S5H5.

Polymorphism and mutation databases

BioMutaiPOTEG.
DMDMi313104320.

Proteomic databases

PaxDbiQ6S5H5.
PeptideAtlasiQ6S5H5.
PRIDEiQ6S5H5.

Protocols and materials databases

DNASUi404785.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000547722; ENSP00000450807; ENSG00000187537. [Q6S5H5-4]
ENST00000547848; ENSP00000450853; ENSG00000187537. [Q6S5H5-3]
ENST00000622767; ENSP00000482662; ENSG00000187537. [Q6S5H5-2]
GeneIDi404785.
KEGGihsa:404785.
UCSCiuc001vuz.3. human. [Q6S5H5-3]

Organism-specific databases

CTDi404785.
GeneCardsiPOTEG.
H-InvDBHIX0037709.
HIX0037863.
HIX0172322.
HGNCiHGNC:33896. POTEG.
HPAiHPA042822.
MIMi608916. gene.
neXtProtiNX_Q6S5H5.
PharmGKBiPA164724853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000293138.
InParanoidiQ6S5H5.
KOiK17299.
OMAiDHDDSSM.
OrthoDBiEOG7FBRHS.
PhylomeDBiQ6S5H5.
TreeFamiTF337879.

Miscellaneous databases

GenomeRNAii404785.
PROiQ6S5H5.
SOURCEiSearch...

Gene expression databases

BgeeiQ6S5H5.
CleanExiHS_POTEG.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths."
    Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.
    Gene 337:45-53(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Prostate.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-458 (ISOFORM 3).

Entry informationi

Entry nameiPOTEG_HUMAN
AccessioniPrimary (citable) accession number: Q6S5H5
Secondary accession number(s): A1L153
, A6NMI9, Q6S5H6, Q6S8J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 30, 2010
Last modified: July 6, 2016
This is version 113 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.