Q6S5H4 (POTEB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
POTE ankyrin domain family member B

Alternative name(s):
ANKRD26-like family B member 1
Prostate, ovary, testis-expressed protein on chromosome 15
Short name=POTE-15

Gene names

Name:	POTEB
Synonyms:	A26B1, POTE15

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	581 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the POTE family. Contains 7 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6S5H4-1)

Also known as: POTE15A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6S5H4-2)

Also known as: POTE15B;

The sequence of this isoform differs from the canonical sequence as follows:
     52-88: Missing.

Isoform 3 (identifier: Q6S5H4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     376-381: EQDLKL → GKEAEE
     382-581: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 581	581	POTE ankyrin domain family member B		PRO_0000066917
Regions
	Repeat	138 – 171	34	ANK 1
	Repeat	172 – 201	30	ANK 2
	Repeat	205 – 234	30	ANK 3
	Repeat	238 – 267	30	ANK 4
	Repeat	271 – 300	30	ANK 5
	Repeat	304 – 333	30	ANK 6
	Repeat	337 – 373	37	ANK 7
	Coiled coil	489 – 577	89	Potential
Natural variations
	Alternative sequence	52 – 88	37	Missing in isoform 2.		VSP_011977
	Alternative sequence	376 – 381	6	EQDLKL → GKEAEE in isoform 3.		VSP_011978
	Alternative sequence	382 – 581	200	Missing in isoform 3.		VSP_011979
	Natural variant	30	1	H → D. Ref.1 Corresponds to variant rs4503752 [ dbSNP | Ensembl ].		VAR_019914
	Natural variant	43	1	M → V. Ref.1 Corresponds to variant rs2605913 [ dbSNP | Ensembl ].		VAR_019915
	Natural variant	64	1	C → W. Corresponds to variant rs2458860 [ dbSNP | Ensembl ].		VAR_019916
	Natural variant	68	1	C → R. Corresponds to variant rs6599743 [ dbSNP | Ensembl ].		VAR_019917
	Natural variant	77	1	T → K. Corresponds to variant rs4429251 [ dbSNP | Ensembl ].		VAR_019918
	Natural variant	88	1	N → D. Corresponds to variant rs2458862 [ dbSNP | Ensembl ].		VAR_019919
	Natural variant	242	1	A → T. Corresponds to variant rs4366679 [ dbSNP | Ensembl ].		VAR_048277
	Natural variant	286	1	Q → E. Ref.3 Corresponds to variant rs2445603 [ dbSNP | Ensembl ].		VAR_019920
	Natural variant	511	1	K → E. Corresponds to variant rs1949282 [ dbSNP | Ensembl ].		VAR_019921
	Natural variant	524	1	R → H. Corresponds to variant rs12148366 [ dbSNP | Ensembl ].		VAR_061016
	Natural variant	535	1	M → K. Corresponds to variant rs1828869 [ dbSNP | Ensembl ].		VAR_019922
	Natural variant	568	1	A → T. Corresponds to variant rs1828868 [ dbSNP | Ensembl ].		VAR_059119
	Natural variant	568	1	A → V. Corresponds to variant rs1828868 [ dbSNP | Ensembl ].		VAR_019923
Experimental info
	Sequence conflict	203	1	D → G in AAH66981. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (POTE15A) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 86D1E88F98BD22DF	FASTA	581	65,710
	10 20 30 40 50 60 MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD DSFMKTLRSK 70 80 90 100 110 120 MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK WCCHCFPCCR GSGKSNVGTW 130 140 150 160 170 180 GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KQKRTALHLA 190 200 210 220 230 240 SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DGNIQDEYGN 250 260 270 280 290 300 TALHYAIYNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA 310 320 330 340 350 360 LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY 370 380 390 400 410 420 KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK MSQEPEINKD CDREVEEEIK 430 440 450 460 470 480 KHGSNPVGLP ENLTNGASAG NGDDGLIPQR KSRKPENQQF PDTENEEYHS DEQNDTQKQL 490 500 510 520 530 540 SEEQNTGISQ DEILTNKQKQ IEVAEKEMNS KLSLSHKKEE DLLRENSMLR EEIAMLRLEL 550 560 570 580 DETKHQNQLR ENKILEEIES VKEKLLKAIQ LNEEALTKTS I
	Isoform 2 (POTE15B) [UniParc]. Checksum: A2591F127EDAD5A1	FASTA	544	61,738
	10 20 30 40 50 60 MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD DSFMKTLRSK 70 80 90 100 110 120 MGKWCCHCFP CCRGSGKSNV GTWGDYDDSA FMEPRYHVRR EDLDKLHRAA WWGKVPRKDL 130 140 150 160 170 180 IVMLRDTDMN KRDKQKRTAL HLASANGNSE VVQLLLDRRC QLNVLDNKKR TALIKAVQCQ 190 200 210 220 230 240 EDECVLMLLE HGADGNIQDE YGNTALHYAI YNEDKLMAKA LLLYGADIES KNKCGLTPLL 250 260 270 280 290 300 LGVHEQKQQV VKFLIKKKAN LNALDRYGRT ALILAVCCGS ASIVNLLLEQ NVDVSSQDLS 310 320 330 340 350 360 GQTAREYAVS SHHHVICELL SDYKEKQMLK ISSENSNPEQ DLKLTSEEES QRLKVSENSQ 370 380 390 400 410 420 PEKMSQEPEI NKDCDREVEE EIKKHGSNPV GLPENLTNGA SAGNGDDGLI PQRKSRKPEN 430 440 450 460 470 480 QQFPDTENEE YHSDEQNDTQ KQLSEEQNTG ISQDEILTNK QKQIEVAEKE MNSKLSLSHK 490 500 510 520 530 540 KEEDLLRENS MLREEIAMLR LELDETKHQN QLRENKILEE IESVKEKLLK AIQLNEEALT KTSI
	Isoform 3 [UniParc]. Checksum: 020E81CF0BEE970A	FASTA	381	42,624
	10 20 30 40 50 60 MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD DSFMKTLRSK 70 80 90 100 110 120 MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK WCCHCFPCCR GSGKSNVGTW 130 140 150 160 170 180 GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KQKRTALHLA 190 200 210 220 230 240 SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DGNIQDEYGN 250 260 270 280 290 300 TALHYAIYNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA 310 320 330 340 350 360 LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY 370 380 KEKQMLKISS ENSNPGKEAE E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths." Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I. Gene 337:45-53(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ASP-30 AND VAL-43. Tissue: Prostate.
[2]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLU-286. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY465170 mRNA. Translation: AAS58869.1. AY465173 mRNA. Translation: AAS58872.1. AC060814 Genomic DNA. No translation available. AC183089 Genomic DNA. No translation available. BC066981 mRNA. Translation: AAH66981.1.
IPI	IPI00479028. IPI00479475. IPI00784226.
RefSeq	NP_997238.2. NM_207355.2.
UniGene	Hs.722659. Hs.742365.
3D structure databases
ProteinModelPortal	Q6S5H4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000413654.
PTM databases
PhosphoSite	Q6S5H4.
Polymorphism databases
DMDM	55976443.
Proteomic databases
PaxDb	Q6S5H4.
PRIDE	Q6S5H4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	339010.
KEGG	hsa:339010.
UCSC	uc010tzg.1. human.
Organism-specific databases
CTD	339010.
GeneCards	GC15M022051.
H-InvDB	HIX0172648. HIX0172649.
HGNC	HGNC:33734. POTEB.
HPA	HPA042822.
MIM	608912. gene.
neXtProt	NX_Q6S5H4.
PharmGKB	PA164724702.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0666.
HOGENOM	HOG000293138.
InParanoid	Q6S5H4.
PhylomeDB	Q6S5H4.
Gene expression databases
CleanEx	HS_POTEB.
Genevestigator	Q6S5H4.
GermOnline	ENSG00000183206. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Pfam	PF12796. Ank_2. 2 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 6 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	339010.
NextBio	97219.
SOURCE	Search...

Entry information

Entry name

POTEB_HUMAN

Accession

Primary (citable) accession number: Q6S5H4
Secondary accession number(s): Q6NXN7, Q6S5H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.