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Protein

POTE ankyrin domain family member B

Gene

POTEB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33809-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member B
Alternative name(s):
ANKRD26-like family B member 1
Prostate, ovary, testis-expressed protein on chromosome 15
Short name:
POTE-15
Gene namesi
Name:POTEB
Synonyms:A26B1, POTE15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:33734. POTEB.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000278522.
PharmGKBiPA164724702.

Polymorphism and mutation databases

DMDMi55976443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669171 – 581POTE ankyrin domain family member BAdd BLAST581

Proteomic databases

MaxQBiQ6S5H4.
PaxDbiQ6S5H4.
PeptideAtlasiQ6S5H4.
PRIDEiQ6S5H4.

PTM databases

iPTMnetiQ6S5H4.
PhosphoSitePlusiQ6S5H4.

Expressioni

Gene expression databases

CleanExiHS_POTEB.
ExpressionAtlasiQ6S5H4. baseline and differential.
GenevisibleiQ6S5H4. HS.

Organism-specific databases

HPAiHPA042822.

Interactioni

Protein-protein interaction databases

BioGridi130821. 26 interactors.
STRINGi9606.ENSP00000299443.

Structurei

3D structure databases

ProteinModelPortaliQ6S5H4.
SMRiQ6S5H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati138 – 171ANK 1Add BLAST34
Repeati172 – 201ANK 2Add BLAST30
Repeati205 – 234ANK 3Add BLAST30
Repeati238 – 267ANK 4Add BLAST30
Repeati271 – 300ANK 5Add BLAST30
Repeati304 – 333ANK 6Add BLAST30
Repeati337 – 373ANK 7Add BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili489 – 577Sequence analysisAdd BLAST89

Sequence similaritiesi

Belongs to the POTE family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000293138.
InParanoidiQ6S5H4.
OrthoDBiEOG091G077A.
PhylomeDBiQ6S5H4.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6S5H4-1) [UniParc]FASTAAdd to basket
Also known as: POTE15A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD
60 70 80 90 100
DSFMKTLRSK MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSNVGTW GDYDDSAFME PRYHVRREDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDMNKRD KQKRTALHLA SANGNSEVVQ LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DGNIQDEYGN TALHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICELLSDY KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK
410 420 430 440 450
MSQEPEINKD CDREVEEEIK KHGSNPVGLP ENLTNGASAG NGDDGLIPQR
460 470 480 490 500
KSRKPENQQF PDTENEEYHS DEQNDTQKQL SEEQNTGISQ DEILTNKQKQ
510 520 530 540 550
IEVAEKEMNS KLSLSHKKEE DLLRENSMLR EEIAMLRLEL DETKHQNQLR
560 570 580
ENKILEEIES VKEKLLKAIQ LNEEALTKTS I
Length:581
Mass (Da):65,710
Last modified:July 5, 2004 - v1
Checksum:i86D1E88F98BD22DF
GO
Isoform 2 (identifier: Q6S5H4-2) [UniParc]FASTAAdd to basket
Also known as: POTE15B

The sequence of this isoform differs from the canonical sequence as follows:
     52-88: Missing.

Show »
Length:544
Mass (Da):61,738
Checksum:iA2591F127EDAD5A1
GO
Isoform 3 (identifier: Q6S5H4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-381: EQDLKL → GKEAEE
     382-581: Missing.

Note: No experimental confirmation available.
Show »
Length:381
Mass (Da):42,624
Checksum:i020E81CF0BEE970A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203D → G in AAH66981 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01991430H → D.1 PublicationCorresponds to variant rs4503752dbSNPEnsembl.1
Natural variantiVAR_01991543M → V.1 PublicationCorresponds to variant rs2605913dbSNPEnsembl.1
Natural variantiVAR_01991664C → W.Corresponds to variant rs2458860dbSNPEnsembl.1
Natural variantiVAR_01991768C → R.Corresponds to variant rs6599743dbSNPEnsembl.1
Natural variantiVAR_01991877T → K.Corresponds to variant rs4429251dbSNPEnsembl.1
Natural variantiVAR_01991988N → D.Corresponds to variant rs2458862dbSNPEnsembl.1
Natural variantiVAR_048277242A → T.Corresponds to variant rs4366679dbSNPEnsembl.1
Natural variantiVAR_019920286Q → E.1 PublicationCorresponds to variant rs2445603dbSNPEnsembl.1
Natural variantiVAR_019921511K → E.Corresponds to variant rs1949282dbSNPEnsembl.1
Natural variantiVAR_061016524R → H.Corresponds to variant rs12148366dbSNPEnsembl.1
Natural variantiVAR_019922535M → K.Corresponds to variant rs1828869dbSNPEnsembl.1
Natural variantiVAR_059119568A → T.Corresponds to variant rs1828868dbSNPEnsembl.1
Natural variantiVAR_019923568A → V.Corresponds to variant rs1828868dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01197752 – 88Missing in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_011978376 – 381EQDLKL → GKEAEE in isoform 3. 1 Publication6
Alternative sequenceiVSP_011979382 – 581Missing in isoform 3. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY465170 mRNA. Translation: AAS58869.1.
AY465173 mRNA. Translation: AAS58872.1.
AC060814 Genomic DNA. No translation available.
AC183089 Genomic DNA. No translation available.
BC066981 mRNA. Translation: AAH66981.1.
CCDSiCCDS73690.1. [Q6S5H4-1]
RefSeqiNP_997238.2. NM_207355.3. [Q6S5H4-1]
XP_011542097.1. XM_011543795.2. [Q6S5H4-3]
UniGeneiHs.722659.
Hs.742365.

Genome annotation databases

GeneIDi102724631.
KEGGihsa:102724631.
UCSCiuc032bug.2. human. [Q6S5H4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY465170 mRNA. Translation: AAS58869.1.
AY465173 mRNA. Translation: AAS58872.1.
AC060814 Genomic DNA. No translation available.
AC183089 Genomic DNA. No translation available.
BC066981 mRNA. Translation: AAH66981.1.
CCDSiCCDS73690.1. [Q6S5H4-1]
RefSeqiNP_997238.2. NM_207355.3. [Q6S5H4-1]
XP_011542097.1. XM_011543795.2. [Q6S5H4-3]
UniGeneiHs.722659.
Hs.742365.

3D structure databases

ProteinModelPortaliQ6S5H4.
SMRiQ6S5H4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130821. 26 interactors.
STRINGi9606.ENSP00000299443.

PTM databases

iPTMnetiQ6S5H4.
PhosphoSitePlusiQ6S5H4.

Polymorphism and mutation databases

DMDMi55976443.

Proteomic databases

MaxQBiQ6S5H4.
PaxDbiQ6S5H4.
PeptideAtlasiQ6S5H4.
PRIDEiQ6S5H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102724631.
KEGGihsa:102724631.
UCSCiuc032bug.2. human. [Q6S5H4-1]

Organism-specific databases

CTDi102724631.
GeneCardsiPOTEB.
H-InvDBHIX0172648.
HIX0172649.
HGNCiHGNC:33734. POTEB.
HPAiHPA042822.
MIMi608912. gene.
neXtProtiNX_Q6S5H4.
OpenTargetsiENSG00000278522.
PharmGKBiPA164724702.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000293138.
InParanoidiQ6S5H4.
OrthoDBiEOG091G077A.
PhylomeDBiQ6S5H4.

Enzyme and pathway databases

BioCyciZFISH:G66-33809-MONOMER.

Miscellaneous databases

GenomeRNAii102724631.
PROiQ6S5H4.
SOURCEiSearch...

Gene expression databases

CleanExiHS_POTEB.
ExpressionAtlasiQ6S5H4. baseline and differential.
GenevisibleiQ6S5H4. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOTEB_HUMAN
AccessioniPrimary (citable) accession number: Q6S5H4
Secondary accession number(s): Q6NXN7, Q6S5H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.