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Protein

POTE ankyrin domain family member B

Gene

POTEB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member B
Alternative name(s):
ANKRD26-like family B member 1
Prostate, ovary, testis-expressed protein on chromosome 15
Short name:
POTE-15
Gene namesi
Name:POTEB
Synonyms:A26B1, POTE15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:33734. POTEB.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724702.

Polymorphism and mutation databases

DMDMi55976443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581POTE ankyrin domain family member BPRO_0000066917Add
BLAST

Proteomic databases

EPDiQ6S5H4.
PaxDbiQ6S5H4.
PeptideAtlasiQ6S5H4.
PRIDEiQ6S5H4.

PTM databases

iPTMnetiQ6S5H4.
PhosphoSiteiQ6S5H4.

Expressioni

Gene expression databases

CleanExiHS_POTEB.
ExpressionAtlasiQ6S5H4. baseline.
GenevisibleiQ6S5H4. HS.

Organism-specific databases

HPAiHPA042822.

Interactioni

Protein-protein interaction databases

BioGridi130821. 26 interactions.
STRINGi9606.ENSP00000299443.

Structurei

3D structure databases

ProteinModelPortaliQ6S5H4.
SMRiQ6S5H4. Positions 123-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati138 – 17134ANK 1Add
BLAST
Repeati172 – 20130ANK 2Add
BLAST
Repeati205 – 23430ANK 3Add
BLAST
Repeati238 – 26730ANK 4Add
BLAST
Repeati271 – 30030ANK 5Add
BLAST
Repeati304 – 33330ANK 6Add
BLAST
Repeati337 – 37337ANK 7Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili489 – 57789Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the POTE family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000293138.
InParanoidiQ6S5H4.
PhylomeDBiQ6S5H4.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6S5H4-1) [UniParc]FASTAAdd to basket

Also known as: POTE15A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD
60 70 80 90 100
DSFMKTLRSK MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSNVGTW GDYDDSAFME PRYHVRREDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDMNKRD KQKRTALHLA SANGNSEVVQ LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DGNIQDEYGN TALHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICELLSDY KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK
410 420 430 440 450
MSQEPEINKD CDREVEEEIK KHGSNPVGLP ENLTNGASAG NGDDGLIPQR
460 470 480 490 500
KSRKPENQQF PDTENEEYHS DEQNDTQKQL SEEQNTGISQ DEILTNKQKQ
510 520 530 540 550
IEVAEKEMNS KLSLSHKKEE DLLRENSMLR EEIAMLRLEL DETKHQNQLR
560 570 580
ENKILEEIES VKEKLLKAIQ LNEEALTKTS I
Length:581
Mass (Da):65,710
Last modified:July 5, 2004 - v1
Checksum:i86D1E88F98BD22DF
GO
Isoform 2 (identifier: Q6S5H4-2) [UniParc]FASTAAdd to basket

Also known as: POTE15B

The sequence of this isoform differs from the canonical sequence as follows:
     52-88: Missing.

Show »
Length:544
Mass (Da):61,738
Checksum:iA2591F127EDAD5A1
GO
Isoform 3 (identifier: Q6S5H4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-381: EQDLKL → GKEAEE
     382-581: Missing.

Note: No experimental confirmation available.
Show »
Length:381
Mass (Da):42,624
Checksum:i020E81CF0BEE970A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031D → G in AAH66981 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301H → D.1 Publication
Corresponds to variant rs4503752 [ dbSNP | Ensembl ].
VAR_019914
Natural varianti43 – 431M → V.1 Publication
Corresponds to variant rs2605913 [ dbSNP | Ensembl ].
VAR_019915
Natural varianti64 – 641C → W.
Corresponds to variant rs2458860 [ dbSNP | Ensembl ].
VAR_019916
Natural varianti68 – 681C → R.
Corresponds to variant rs6599743 [ dbSNP | Ensembl ].
VAR_019917
Natural varianti77 – 771T → K.
Corresponds to variant rs4429251 [ dbSNP | Ensembl ].
VAR_019918
Natural varianti88 – 881N → D.
Corresponds to variant rs2458862 [ dbSNP | Ensembl ].
VAR_019919
Natural varianti242 – 2421A → T.
Corresponds to variant rs4366679 [ dbSNP | Ensembl ].
VAR_048277
Natural varianti286 – 2861Q → E.1 Publication
Corresponds to variant rs2445603 [ dbSNP | Ensembl ].
VAR_019920
Natural varianti511 – 5111K → E.
Corresponds to variant rs1949282 [ dbSNP | Ensembl ].
VAR_019921
Natural varianti524 – 5241R → H.
Corresponds to variant rs12148366 [ dbSNP | Ensembl ].
VAR_061016
Natural varianti535 – 5351M → K.
Corresponds to variant rs1828869 [ dbSNP | Ensembl ].
VAR_019922
Natural varianti568 – 5681A → T.
Corresponds to variant rs1828868 [ dbSNP | Ensembl ].
VAR_059119
Natural varianti568 – 5681A → V.
Corresponds to variant rs1828868 [ dbSNP | Ensembl ].
VAR_019923

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 8837Missing in isoform 2. 1 PublicationVSP_011977Add
BLAST
Alternative sequencei376 – 3816EQDLKL → GKEAEE in isoform 3. 1 PublicationVSP_011978
Alternative sequencei382 – 581200Missing in isoform 3. 1 PublicationVSP_011979Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY465170 mRNA. Translation: AAS58869.1.
AY465173 mRNA. Translation: AAS58872.1.
AC060814 Genomic DNA. No translation available.
AC183089 Genomic DNA. No translation available.
BC066981 mRNA. Translation: AAH66981.1.
CCDSiCCDS73690.1. [Q6S5H4-1]
RefSeqiNP_997238.2. NM_207355.3. [Q6S5H4-1]
XP_011542097.1. XM_011543795.1. [Q6S5H4-3]
UniGeneiHs.722659.
Hs.742365.

Genome annotation databases

GeneIDi102724631.
KEGGihsa:102724631.
UCSCiuc032bug.2. human. [Q6S5H4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY465170 mRNA. Translation: AAS58869.1.
AY465173 mRNA. Translation: AAS58872.1.
AC060814 Genomic DNA. No translation available.
AC183089 Genomic DNA. No translation available.
BC066981 mRNA. Translation: AAH66981.1.
CCDSiCCDS73690.1. [Q6S5H4-1]
RefSeqiNP_997238.2. NM_207355.3. [Q6S5H4-1]
XP_011542097.1. XM_011543795.1. [Q6S5H4-3]
UniGeneiHs.722659.
Hs.742365.

3D structure databases

ProteinModelPortaliQ6S5H4.
SMRiQ6S5H4. Positions 123-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130821. 26 interactions.
STRINGi9606.ENSP00000299443.

PTM databases

iPTMnetiQ6S5H4.
PhosphoSiteiQ6S5H4.

Polymorphism and mutation databases

DMDMi55976443.

Proteomic databases

EPDiQ6S5H4.
PaxDbiQ6S5H4.
PeptideAtlasiQ6S5H4.
PRIDEiQ6S5H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102724631.
KEGGihsa:102724631.
UCSCiuc032bug.2. human. [Q6S5H4-1]

Organism-specific databases

CTDi102724631.
GeneCardsiPOTEB.
H-InvDBHIX0172648.
HIX0172649.
HGNCiHGNC:33734. POTEB.
HPAiHPA042822.
MIMi608912. gene.
neXtProtiNX_Q6S5H4.
PharmGKBiPA164724702.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000293138.
InParanoidiQ6S5H4.
PhylomeDBiQ6S5H4.

Miscellaneous databases

GenomeRNAii102724631.
PROiQ6S5H4.
SOURCEiSearch...

Gene expression databases

CleanExiHS_POTEB.
ExpressionAtlasiQ6S5H4. baseline.
GenevisibleiQ6S5H4. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths."
    Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.
    Gene 337:45-53(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ASP-30 AND VAL-43.
    Tissue: Prostate.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLU-286.
    Tissue: Testis.

Entry informationi

Entry nameiPOTEB_HUMAN
AccessioniPrimary (citable) accession number: Q6S5H4
Secondary accession number(s): Q6NXN7, Q6S5H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.