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Protein

POTE ankyrin domain family member H

Gene

POTEH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32359-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member H
Alternative name(s):
ANKRD26-like family C member 3
Prostate, ovary, testis-expressed protein on chromosome 22
Short name:
POTE-22
Gene namesi
Name:POTEH
Synonyms:A26C3, ACTBL1, POTE22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:133. POTEH.

Pathology & Biotechi

Organism-specific databases

DisGeNETi23784.
OpenTargetsiENSG00000198062.
PharmGKBiPA24458.

Polymorphism and mutation databases

BioMutaiPOTEH.
DMDMi166898062.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669181 – 545POTE ankyrin domain family member HAdd BLAST545

Proteomic databases

EPDiQ6S545.
MaxQBiQ6S545.
PaxDbiQ6S545.
PeptideAtlasiQ6S545.
PRIDEiQ6S545.

PTM databases

iPTMnetiQ6S545.
PhosphoSitePlusiQ6S545.

Expressioni

Gene expression databases

BgeeiENSG00000198062.
CleanExiHS_POTEH.
ExpressionAtlasiQ6S545. baseline and differential.

Organism-specific databases

HPAiHPA042822.

Interactioni

Protein-protein interaction databases

IntActiQ6S545. 1 interactor.
STRINGi9606.ENSP00000340610.

Structurei

3D structure databases

ProteinModelPortaliQ6S545.
SMRiQ6S545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati180 – 208ANK 1Add BLAST29
Repeati209 – 238ANK 2Add BLAST30
Repeati242 – 271ANK 3Add BLAST30
Repeati275 – 304ANK 4Add BLAST30
Repeati308 – 337ANK 5Add BLAST30
Repeati341 – 370ANK 6Add BLAST30
Repeati374 – 404ANK 7Add BLAST31

Sequence similaritiesi

Belongs to the POTE family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000293138.
InParanoidiQ6S545.
KOiK17299.
OMAiLLEPRYH.
OrthoDBiEOG091G077A.
PhylomeDBiQ6S545.
TreeFamiTF337879.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6S545-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFAWCRGSGK SNVGTSGDHD
60 70 80 90 100
DSAMKTLRSK MGKWCCHCFP WCRGSGKSNV GTSGDHDDSA MKTLRSKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSNVGTS GDHDDSAMKT LRSKMGKWCC HCFPCCRGSG
160 170 180 190 200
KNKVGPWGDY DDSAFMEPRY HVRREDLDKL HRAAWWGKVP RKDLIVMLKD
210 220 230 240 250
TDMNKKDKQK RTALHLASAN GNSEVVKLLL DRRCQLNILD NKKRTALTKA
260 270 280 290 300
VQCQEDECAL MLLEHGTDPN IPDEYGNTAL HYAIYNEDKL MAKALLLYGA
310 320 330 340 350
DIESKNKHGL TPLLLGVHEQ KQQVVKFLIK KKANLNALDR YGRTALILAV
360 370 380 390 400
CCGSASIVSL LLEQNIDVSS QDLSGQTARE YAVSSRHNVI CQLLSDYKEK
410 420 430 440 450
QILKVSSENS NPEQDLKLTS EEESQRLKGS ENSQPEEMSQ EPEINKGGDR
460 470 480 490 500
KVEEEMKKHG STHMGFPENL TNGATADNGD DGLIPPRKSR TPESQQFPDT
510 520 530 540
ENEQYHSDEQ NDTQKQLSEE QNTGILQDEI LIHEEKQIEV AENEF
Note: No experimental confirmation available.
Length:545
Mass (Da):60,965
Last modified:February 5, 2008 - v3
Checksum:i35F2B1C6D670B181
GO
Isoform 2 (identifier: Q6S545-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-545: Missing.

Note: No experimental confirmation available.
Show »
Length:288
Mass (Da):32,196
Checksum:iE8CC31DC2CB2B765
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238I → V in AAS58873 (PubMed:15276201).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039738289 – 545Missing in isoform 2. 1 PublicationAdd BLAST257

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR545463 Genomic DNA. No translation available.
AP000529 Genomic DNA. No translation available.
AY466021 mRNA. Translation: AAS58873.1.
CCDSiCCDS74808.1. [Q6S545-1]
RefSeqiNP_001129685.1. NM_001136213.1. [Q6S545-1]
UniGeneiHs.581075.

Genome annotation databases

EnsembliENST00000343518; ENSP00000340610; ENSG00000198062. [Q6S545-1]
GeneIDi23784.
KEGGihsa:23784.
UCSCiuc010gqp.3. human. [Q6S545-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR545463 Genomic DNA. No translation available.
AP000529 Genomic DNA. No translation available.
AY466021 mRNA. Translation: AAS58873.1.
CCDSiCCDS74808.1. [Q6S545-1]
RefSeqiNP_001129685.1. NM_001136213.1. [Q6S545-1]
UniGeneiHs.581075.

3D structure databases

ProteinModelPortaliQ6S545.
SMRiQ6S545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6S545. 1 interactor.
STRINGi9606.ENSP00000340610.

PTM databases

iPTMnetiQ6S545.
PhosphoSitePlusiQ6S545.

Polymorphism and mutation databases

BioMutaiPOTEH.
DMDMi166898062.

Proteomic databases

EPDiQ6S545.
MaxQBiQ6S545.
PaxDbiQ6S545.
PeptideAtlasiQ6S545.
PRIDEiQ6S545.

Protocols and materials databases

DNASUi23784.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343518; ENSP00000340610; ENSG00000198062. [Q6S545-1]
GeneIDi23784.
KEGGihsa:23784.
UCSCiuc010gqp.3. human. [Q6S545-1]

Organism-specific databases

CTDi23784.
DisGeNETi23784.
GeneCardsiPOTEH.
H-InvDBHIX0041403.
HGNCiHGNC:133. POTEH.
HPAiHPA042822.
MIMi608913. gene.
neXtProtiNX_Q6S545.
OpenTargetsiENSG00000198062.
PharmGKBiPA24458.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000293138.
InParanoidiQ6S545.
KOiK17299.
OMAiLLEPRYH.
OrthoDBiEOG091G077A.
PhylomeDBiQ6S545.
TreeFamiTF337879.

Enzyme and pathway databases

BioCyciZFISH:G66-32359-MONOMER.

Miscellaneous databases

GenomeRNAii23784.
PROiQ6S545.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198062.
CleanExiHS_POTEH.
ExpressionAtlasiQ6S545. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOTEH_HUMAN
AccessioniPrimary (citable) accession number: Q6S545
Secondary accession number(s): A2CEK4, A6NCI1, A9Z1W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.