Q6S545 (POTEH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
POTE ankyrin domain family member H

Alternative name(s):
ANKRD26-like family C member 3
Prostate, ovary, testis-expressed protein on chromosome 22
Short name=POTE-22

Gene names

Name:	POTEH
Synonyms:	A26C3, ACTBL1, POTE22

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	545 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the POTE family. Contains 7 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6S545-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q6S545-2)

The sequence of this isoform differs from the canonical sequence as follows:
     289-545: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 545	545	POTE ankyrin domain family member H		PRO_0000066918
Regions
	Repeat	180 – 208	29	ANK 1
	Repeat	209 – 238	30	ANK 2
	Repeat	242 – 271	30	ANK 3
	Repeat	275 – 304	30	ANK 4
	Repeat	308 – 337	30	ANK 5
	Repeat	341 – 370	30	ANK 6
	Repeat	374 – 404	31	ANK 7
Natural variations
	Alternative sequence	289 – 545	257	Missing in isoform 2.		VSP_039738
Experimental info
	Sequence conflict	238	1	I → V in AAS58873. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 5, 2008. Version 3. Checksum: 35F2B1C6D670B181	FASTA	545	60,965
	10 20 30 40 50 60 MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFAWCRGSGK SNVGTSGDHD DSAMKTLRSK 70 80 90 100 110 120 MGKWCCHCFP WCRGSGKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSNVGTS 130 140 150 160 170 180 GDHDDSAMKT LRSKMGKWCC HCFPCCRGSG KNKVGPWGDY DDSAFMEPRY HVRREDLDKL 190 200 210 220 230 240 HRAAWWGKVP RKDLIVMLKD TDMNKKDKQK RTALHLASAN GNSEVVKLLL DRRCQLNILD 250 260 270 280 290 300 NKKRTALTKA VQCQEDECAL MLLEHGTDPN IPDEYGNTAL HYAIYNEDKL MAKALLLYGA 310 320 330 340 350 360 DIESKNKHGL TPLLLGVHEQ KQQVVKFLIK KKANLNALDR YGRTALILAV CCGSASIVSL 370 380 390 400 410 420 LLEQNIDVSS QDLSGQTARE YAVSSRHNVI CQLLSDYKEK QILKVSSENS NPEQDLKLTS 430 440 450 460 470 480 EEESQRLKGS ENSQPEEMSQ EPEINKGGDR KVEEEMKKHG STHMGFPENL TNGATADNGD 490 500 510 520 530 540 DGLIPPRKSR TPESQQFPDT ENEQYHSDEQ NDTQKQLSEE QNTGILQDEI LIHEEKQIEV AENEF
	Isoform 2 [UniParc]. Checksum: E8CC31DC2CB2B765	FASTA	288	32,196
	10 20 30 40 50 60 MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFAWCRGSGK SNVGTSGDHD DSAMKTLRSK 70 80 90 100 110 120 MGKWCCHCFP WCRGSGKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSNVGTS 130 140 150 160 170 180 GDHDDSAMKT LRSKMGKWCC HCFPCCRGSG KNKVGPWGDY DDSAFMEPRY HVRREDLDKL 190 200 210 220 230 240 HRAAWWGKVP RKDLIVMLKD TDMNKKDKQK RTALHLASAN GNSEVVKLLL DRRCQLNILD 250 260 270 280 NKKRTALTKA VQCQEDECAL MLLEHGTDPN IPDEYGNTAL HYAIYNED

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths." Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I. Gene 337:45-53(2004) [PubMed: 15276201] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Prostate.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR545463 Genomic DNA. No translation available. AP000529 Genomic DNA. No translation available. AY466021 mRNA. Translation: AAS58873.1.
IPI	IPI00436748. IPI00970870.
RefSeq	NP_001129685.1. NM_001136213.1.
UniGene	Hs.581075.
3D structure databases
ProteinModelPortal	Q6S545.
SMR	Q6S545. Positions 175-399.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6S545. 1 interaction.
PTM databases
PhosphoSite	Q6S545.
Polymorphism databases
DMDM	166898062.
Proteomic databases
PRIDE	Q6S545.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343518; ENSP00000340610; ENSG00000198062.
GeneID	23784.
KEGG	hsa:23784.
UCSC	uc002zli.1. human.
Organism-specific databases
CTD	23784.
GeneCards	GC22M016256.
HGNC	HGNC:133. POTEH.
MIM	608913. gene.
neXtProt	NX_Q6S545.
PharmGKB	PA164724880. PA24458.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17475.
GeneTree	ENSGT00560000076605.
HOGENOM	HBG505546.
OMA	GQMAREY.
OrthoDB	EOG49S686.
PhylomeDB	Q6S545.
Gene expression databases
Bgee	Q6S545.
CleanEx	HS_POTEH.
Genevestigator	Q6S545.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 2 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 6 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

POTEH_HUMAN

Accession

Primary (citable) accession number: Q6S545
Secondary accession number(s): A2CEK4, A6NCI1, A9Z1W0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	February 5, 2008
Last modified:	December 14, 2011
This is version 66 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.