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Protein

Metallothionein

Gene

mt

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi4 – 41Divalent metal cation; cluster B
Metal bindingi6 – 61Divalent metal cation; cluster B
Metal bindingi12 – 121Divalent metal cation; cluster B
Metal bindingi14 – 141Divalent metal cation; cluster B
Metal bindingi18 – 181Divalent metal cation; cluster B
Metal bindingi20 – 201Divalent metal cation; cluster B
Metal bindingi23 – 231Divalent metal cation; cluster B
Metal bindingi25 – 251Divalent metal cation; cluster B
Metal bindingi28 – 281Divalent metal cation; cluster B
Metal bindingi32 – 321Divalent metal cation; cluster A
Metal bindingi33 – 331Divalent metal cation; cluster A
Metal bindingi35 – 351Divalent metal cation; cluster A
Metal bindingi36 – 361Divalent metal cation; cluster A
Metal bindingi40 – 401Divalent metal cation; cluster A
Metal bindingi43 – 431Divalent metal cation; cluster A
Metal bindingi47 – 471Divalent metal cation; cluster A
Metal bindingi49 – 491Divalent metal cation; cluster A
Metal bindingi54 – 541Divalent metal cation; cluster A
Metal bindingi58 – 581Divalent metal cation; cluster A
Metal bindingi59 – 591Divalent metal cation; cluster A

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. response to cadmium ion Source: Ensembl
  2. response to copper ion Source: Ensembl
  3. response to methylmercury Source: Ensembl
  4. response to zinc ion Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein
Short name:
MT
Gene namesi
Name:mt
OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038 Componenti: Chromosome 6

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060MetallothioneinPRO_0000197299Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6S4N8.
SMRiQ6S4N8. Positions 2-29, 31-60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828BetaAdd
BLAST
Regioni29 – 6032AlphaAdd
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000112385.
HOGENOMiHOG000236262.
InParanoidiQ6S4N8.
KOiK14739.
OMAiVCKGGEG.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6S4N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPCDCSKTG KCNCGGSCTC TNCSCTSCKK SCCACCPSGC TKCASGCVCK
60
GKTCDTTCCQ
Length:60
Mass (Da):6,007
Last modified:July 4, 2004 - v1
Checksum:i5971EED1816C471B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466516 mRNA. Translation: AAR30249.1.
RefSeqiNP_001098255.1. NM_001104785.1.
UniGeneiOla.15510.

Genome annotation databases

EnsembliENSORLT00000019509; ENSORLP00000019508; ENSORLG00000015580.
GeneIDi100049397.
KEGGiola:100049397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466516 mRNA. Translation: AAR30249.1.
RefSeqiNP_001098255.1. NM_001104785.1.
UniGeneiOla.15510.

3D structure databases

ProteinModelPortaliQ6S4N8.
SMRiQ6S4N8. Positions 2-29, 31-60.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSORLT00000019509; ENSORLP00000019508; ENSORLG00000015580.
GeneIDi100049397.
KEGGiola:100049397.

Phylogenomic databases

GeneTreeiENSGT00730000112385.
HOGENOMiHOG000236262.
InParanoidiQ6S4N8.
KOiK14739.
OMAiVCKGGEG.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Metallothionein cDNA of medaka (Oryzias latipes)."
    Ryu J., Bae H., Lee M., Haasch M.L.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiMT_ORYLA
AccessioniPrimary (citable) accession number: Q6S4N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2004
Last sequence update: July 4, 2004
Last modified: January 6, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.