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Q6S4N8

- MT_ORYLA

UniProt

Q6S4N8 - MT_ORYLA

Protein

Metallothionein

Gene

mt

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi4 – 41Divalent metal cation; cluster B
    Metal bindingi6 – 61Divalent metal cation; cluster B
    Metal bindingi12 – 121Divalent metal cation; cluster B
    Metal bindingi14 – 141Divalent metal cation; cluster B
    Metal bindingi18 – 181Divalent metal cation; cluster B
    Metal bindingi20 – 201Divalent metal cation; cluster B
    Metal bindingi23 – 231Divalent metal cation; cluster B
    Metal bindingi25 – 251Divalent metal cation; cluster B
    Metal bindingi28 – 281Divalent metal cation; cluster B
    Metal bindingi32 – 321Divalent metal cation; cluster A
    Metal bindingi33 – 331Divalent metal cation; cluster A
    Metal bindingi35 – 351Divalent metal cation; cluster A
    Metal bindingi36 – 361Divalent metal cation; cluster A
    Metal bindingi40 – 401Divalent metal cation; cluster A
    Metal bindingi43 – 431Divalent metal cation; cluster A
    Metal bindingi47 – 471Divalent metal cation; cluster A
    Metal bindingi49 – 491Divalent metal cation; cluster A
    Metal bindingi54 – 541Divalent metal cation; cluster A
    Metal bindingi58 – 581Divalent metal cation; cluster A
    Metal bindingi59 – 591Divalent metal cation; cluster A

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein
    Short name:
    MT
    Gene namesi
    Name:mt
    OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
    Taxonomic identifieri8090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
    ProteomesiUP000001038: Chromosome 6

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6060MetallothioneinPRO_0000197299Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6S4N8.
    SMRiQ6S4N8. Positions 2-29, 31-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2828BetaAdd
    BLAST
    Regioni29 – 6032AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00730000112385.
    HOGENOMiHOG000236262.
    InParanoidiQ6S4N8.
    KOiK14739.
    OMAiTDSCKCE.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6S4N8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPCDCSKTG KCNCGGSCTC TNCSCTSCKK SCCACCPSGC TKCASGCVCK   50
    GKTCDTTCCQ 60
    Length:60
    Mass (Da):6,007
    Last modified:July 5, 2004 - v1
    Checksum:i5971EED1816C471B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY466516 mRNA. Translation: AAR30249.1.
    RefSeqiNP_001098255.1. NM_001104785.1.
    UniGeneiOla.15510.

    Genome annotation databases

    EnsembliENSORLT00000019509; ENSORLP00000019508; ENSORLG00000015580.
    GeneIDi100049397.
    KEGGiola:100049397.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY466516 mRNA. Translation: AAR30249.1 .
    RefSeqi NP_001098255.1. NM_001104785.1.
    UniGenei Ola.15510.

    3D structure databases

    ProteinModelPortali Q6S4N8.
    SMRi Q6S4N8. Positions 2-29, 31-60.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSORLT00000019509 ; ENSORLP00000019508 ; ENSORLG00000015580 .
    GeneIDi 100049397.
    KEGGi ola:100049397.

    Phylogenomic databases

    GeneTreei ENSGT00730000112385.
    HOGENOMi HOG000236262.
    InParanoidi Q6S4N8.
    KOi K14739.
    OMAi TDSCKCE.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Metallothionein cDNA of medaka (Oryzias latipes)."
      Ryu J., Bae H., Lee M., Haasch M.L.
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiMT_ORYLA
    AccessioniPrimary (citable) accession number: Q6S4N8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3