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Protein
Submitted name:

Acetylcholine receptor delta subunit

Gene
N/A
Organism
Torpedo marmorata (Marbled electric ray)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Acetylcholine receptor delta subunitImported
OrganismiTorpedo marmorata (Marbled electric ray)Imported
Taxonomic identifieri7788 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaTorpediniformesTorpedinidaeTorpedo

Subcellular locationi

  • Cell junctionsynapsepostsynaptic cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation
  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei247 – 270HelicalSequence analysisAdd BLAST24
Transmembranei282 – 300HelicalSequence analysisAdd BLAST19
Transmembranei312 – 333HelicalSequence analysisAdd BLAST22
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500427961222 – 522Sequence analysisAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi151 ↔ 165Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BG9electron microscopy4.00C22-505[»]
4AQ5electron microscopy6.20C1-522[»]
4AQ9electron microscopy6.20C1-522[»]
4BOGelectron microscopy50.001/C/H/M/R/W1-522[»]
4BOIelectron microscopy41.00C1-522[»]
4BONelectron microscopy40.00C1-522[»]
4BOOelectron microscopy42.00C1-522[»]
4BORelectron microscopy42.00C1-522[»]
4BOTelectron microscopy42.00C1-522[»]
ProteinModelPortaliQ6S3H8.
SMRiQ6S3H8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6S3H8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 246Neur_chan_LBDInterPro annotationAdd BLAST222
Domaini254 – 494Neur_chan_membInterPro annotationAdd BLAST241

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG003756.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6S3H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNIHFVYLL ISCLYYSGCS GVNEEERLIN DLLIVNKYNK HVRPVKHNNE
60 70 80 90 100
VVNIALSLTL SNLISLKETD ETLTTNVWMD HAWYDHRLTW NASEYSDISI
110 120 130 140 150
LRLRPELIWI PDIVLQNNND GQYNVAYFCN VLVRPNGYVT WLPPAIFRSS
160 170 180 190 200
CPINVLYFPF DWQNCSLKFT ALNYNANEIS MDLMTDTIDG KDYPIEWIII
210 220 230 240 250
DPEAFTENGE WEIIHKPAKK NIYGDKFPNG TNYQDVTFYL IIRRKPLFYV
260 270 280 290 300
INFITPCVLI SFLAALAFYL PAESGEKMST AICVLLAQAV FLLLTSQRLP
310 320 330 340 350
ETALAVPLIG KYLMFIMSLV TGVVVNCGIV LNFHFRTPST HVLSTRVKQI
360 370 380 390 400
FLEKLPRILH MSRVDEIEQP DWQNDLKLRR SSSVGYISKA QEYFNIKSRS
410 420 430 440 450
ELMFEKQSER HGLVPRVTPR IGFGNNNENI AASDQLHDEI KSGIDSTNYI
460 470 480 490 500
VKQIKEKNAY DEEVGNWNLV GQTIDRLSMF IITPVMVLGT IFIFVMGNFN
510 520
RPPAKPFEGD PFDYSSDHPR CA
Length:522
Mass (Da):59,959
Last modified:July 5, 2004 - v1
Checksum:i6CE58EB60719E31D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY472105 mRNA. Translation: AAR29363.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY472105 mRNA. Translation: AAR29363.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BG9electron microscopy4.00C22-505[»]
4AQ5electron microscopy6.20C1-522[»]
4AQ9electron microscopy6.20C1-522[»]
4BOGelectron microscopy50.001/C/H/M/R/W1-522[»]
4BOIelectron microscopy41.00C1-522[»]
4BONelectron microscopy40.00C1-522[»]
4BOOelectron microscopy42.00C1-522[»]
4BORelectron microscopy42.00C1-522[»]
4BOTelectron microscopy42.00C1-522[»]
ProteinModelPortaliQ6S3H8.
SMRiQ6S3H8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG003756.

Miscellaneous databases

EvolutionaryTraceiQ6S3H8.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6S3H8_TORMA
AccessioniPrimary (citable) accession number: Q6S3H8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 12, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.