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Protein

Kinesin-related protein 13

Gene

kif13

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Cooperates with dynein to control the spindle elongation rate, but is dispensable for mitosis.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi106 – 113ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • microtubule-based movement Source: GO_Central
  • mitotic spindle assembly Source: GO_Central
  • spindle elongation Source: dictyBase
  • spindle organization Source: dictyBase
  • transport Source: UniProtKB-KW

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-DDI-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-related protein 13
Alternative name(s):
Kinesin family member 13
Kinesin-5
Gene namesi
Name:kif13
ORF Names:DDB_G0288361
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288361. kif13.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003655881 – 1265Kinesin-related protein 13Add BLAST1265

Proteomic databases

PaxDbiQ6RZZ9.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6RZZ9. 1 interactor.
STRINGi44689.DDB0201557.

Structurei

3D structure databases

ProteinModelPortaliQ6RZZ9.
SMRiQ6RZZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 350Kinesin motorPROSITE-ProRule annotationAdd BLAST328

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili331 – 459Sequence analysisAdd BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi622 – 630Poly-Asn9
Compositional biasi935 – 948Poly-SerAdd BLAST14
Compositional biasi1020 – 1023Poly-Gln4
Compositional biasi1049 – 1063Poly-GlnAdd BLAST15

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0243. Eukaryota.
COG5059. LUCA.
InParanoidiQ6RZZ9.
KOiK10398.
OMAiDYNIRAS.
PhylomeDBiQ6RZZ9.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR036961. Kinesin_motor_dom_sf.
IPR027417. P-loop_NTPase.
IPR011990. TPR-like_helical_dom_sf.
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6RZZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITGLSIHNQ INKKNEPVKK EQNIQAFVRV RPFSVYELNQ GVTTVPIRVS
60 70 80 90 100
DSSKEVLCEY KGTTRQYKFD HVFDQDSIQS EVFNIAVKPI CDEVLLGFNG
110 120 130 140 150
TIFVYGQTGT GKTHTMEGKH GSNEDMGIIP RTINYLFQCL EQSGADYNIR
160 170 180 190 200
ASHLEIYKEE IFDLLACNGN ENLNKPLGMF DTQKGFKIPE LEEIVVNDRQ
210 220 230 240 250
SILNVLAKSC KRRQTAETQY NKQSSRSHCI FSITVHVKET SVGGEDLIKI
260 270 280 290 300
GKLNLVDLAG SENAEKSGNN DRLREAALIN KSLLTLGKVI TDLTNNEKHI
310 320 330 340 350
PYRSSQLTKI LQDSLGGKTK TSIIATVSPS LVNLEETINT LEYALKAKNI
360 370 380 390 400
KNTPQINQRM SKNSLLKEQS SEIAHLKQLL QAAYDKNGVY LTIDVYEQMK
410 420 430 440 450
RELEEKCSQQ SITEHKMEAQ RHEISSMRKS FDEQTMLFEE AMNELESSKK
460 470 480 490 500
QQQEKQKFID QFISQDTMLR SNLGSAVQDL SKLHEKLDTM KSTERENQKS
510 520 530 540 550
IIDSKSILSK RLTDLNQMLV SKLQMGQNEL LESLSVQLKV VHDQQTKSNQ
560 570 580 590 600
LIGKRINNLS QLIDSSVLQI QQLNNDDKQQ TQPLLKLNKE SNDLFMKLDK
610 620 630 640 650
TIQQLSDQIK IILSDFSLPF FNSNNNNSNN GDEIIDDSLI NNCFKLINDH
660 670 680 690 700
VNKSDLIVSQ QNKLIQEFSE SMSQWMLHQS QYIIEQRDYQ KQLKEKQILN
710 720 730 740 750
NTQWEKKLLS KLGQVIQQFS KNFTDSTSVY YDTMDNNLQH FEKQFNSINN
760 770 780 790 800
HSRQQVESLS NNLQQSSTLS HQFESTVKSV LNDHHANNKK VDPKLIESIE
810 820 830 840 850
KAKKRINQLT DGCIDLSQRQ RQCTNQFNEA FTDFTFGIQS QKDILDRVII
860 870 880 890 900
EKNQVHEILP LIEKSKSTFK ENIDTLIHSL DSRKSIIQSS TNECSNQLNS
910 920 930 940 950
LISSIPSYLD SAIKVTSKSG ETPSKKHFDI PSPISTSSSS SSSSSISSIH
960 970 980 990 1000
SNAGGKENNH QSINNSIKSN NFDGSKSINC DNMKIDTPQK SSTIPITPKS
1010 1020 1030 1040 1050
LKLNLNSTPK SVSKNLKSSQ QQQPLIVPSS NQLTLSAKKL SNKEYQRLQQ
1060 1070 1080 1090 1100
QQQQQQQEQQ QQQSAKKKKL AIEKQLMITT SPTLSLVNES PFSSPKLSKQ
1110 1120 1130 1140 1150
KILQDQIQPP QPPSILSQLN STPISFLQPQ QPQQQPPSFF NNLNGSFNRG
1160 1170 1180 1190 1200
NNSIDFSLLD DDSDSDNSDD DVRSLLSSNK KSSRASKNAV VSKKVGLTPS
1210 1220 1230 1240 1250
RKLKGVNSSA NQSLNVKKSK PILTSLSKKQ NISTPIIHSS KPSIFGGGST
1260
ISSKLKSLKQ QTPLK
Length:1,265
Mass (Da):142,748
Last modified:July 5, 2004 - v1
Checksum:iA9A1AF17F098BB86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484466 Genomic DNA. Translation: AAR39442.1.
AAFI02000111 Genomic DNA. Translation: EAL63277.1.
RefSeqiXP_636780.1. XM_631688.1.

Genome annotation databases

EnsemblProtistsiEAL63277; EAL63277; DDB_G0288361.
GeneIDi8626583.
KEGGiddi:DDB_G0288361.

Similar proteinsi

Entry informationi

Entry nameiKIF13_DICDI
AccessioniPrimary (citable) accession number: Q6RZZ9
Secondary accession number(s): Q54J21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families