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Protein

Outer membrane protein Omp38

Gene

omp38

Organism
Acinetobacter baumannii
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Porin. Induces apoptosis in human laryngeal epithelial HEp-2 cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor).2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Apoptosis, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein Omp38
Alternative name(s):
Outer membrane protein OmpA
Outer membrane protein OmpAb
Gene namesi
Name:omp38
Synonyms:ompA
OrganismiAcinetobacter baumannii
Taxonomic identifieri470 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 356337Outer membrane protein Omp38PRO_0000290208Add
BLAST

Interactioni

Subunit structurei

Homotrimer. Forms a pore with a size of 1.3 nm.1 Publication

Protein-protein interaction databases

STRINGi575584.HMPREF0010_02782.

Structurei

Secondary structure

1
356
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi221 – 23313Combined sources
Helixi243 – 2453Combined sources
Helixi246 – 25813Combined sources
Beta strandi263 – 2686Combined sources
Helixi276 – 29722Combined sources
Helixi302 – 3043Combined sources
Beta strandi305 – 3095Combined sources
Helixi322 – 3287Combined sources
Beta strandi329 – 33911Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TD3X-ray1.59A/B/C/D/E/F/G/H221-339[»]
3TD4X-ray1.79A/B/C/D/E/F/G/H221-339[»]
3TD5X-ray2.00A/B/C/D/E/F/G/H221-339[»]
4G4YX-ray1.70A/B/C/D/E/F/G/H221-339[»]
4G4ZX-ray1.80A/B/C/D/E/F/G/H221-339[»]
4G88X-ray1.70A/B/C/D/E/F/G/H221-339[»]
ProteinModelPortaliQ6RYW5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6RYW5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini221 – 339119OmpA-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the OmpA family.Curated
Contains 1 OmpA-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108WHA. Bacteria.
COG2885. LUCA.

Family and domain databases

Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR027385. OMP_b-brl.
IPR006664. OMP_bac.
IPR006665. OmpA-like.
[Graphical view]
PfamiPF13505. OMP_b-brl. 1 hit.
PF00691. OmpA. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS51123. OMPA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RYW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSRIALAT MLVAAPLAAA NAGVTVTPLL LGYTFQDSQH NNGGKDGNLT
60 70 80 90 100
NGPELQDDLF VGAALGIELT PWLGFEAEYN QVKGDVDGAS AGAEYKQKQI
110 120 130 140 150
NGNFYVTSDL ITKNYDSKIK PYVLLGAGHY KYDFDGVNRG TRGTSEEGTL
160 170 180 190 200
GNAGVGAFWR LNDALSLRTE ARATYNADEE FWNYTALAGL NVVLGGHLKP
210 220 230 240 250
AAPVVEVAPV EPTPVAPQPQ ELTEDLNMEL RVFFDTNKSN IKDQYKPEIA
260 270 280 290 300
KVAEKLSEYP NATARIEGHT DNTGPRKLNE RLSLARANSV KSALVNEYNV
310 320 330 340 350
DASRLSTQGF AWDQPIADNK TKEGRAMNRR VFATITGSRT VVVQPGQEAA

APAAAQ
Length:356
Mass (Da):38,420
Last modified:July 5, 2004 - v1
Checksum:iF6E424870C93C42F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY485227 Genomic DNA. Translation: AAR83911.1.
RefSeqiWP_000777878.1. NZ_LNCY01000010.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY485227 Genomic DNA. Translation: AAR83911.1.
RefSeqiWP_000777878.1. NZ_LNCY01000010.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TD3X-ray1.59A/B/C/D/E/F/G/H221-339[»]
3TD4X-ray1.79A/B/C/D/E/F/G/H221-339[»]
3TD5X-ray2.00A/B/C/D/E/F/G/H221-339[»]
4G4YX-ray1.70A/B/C/D/E/F/G/H221-339[»]
4G4ZX-ray1.80A/B/C/D/E/F/G/H221-339[»]
4G88X-ray1.70A/B/C/D/E/F/G/H221-339[»]
ProteinModelPortaliQ6RYW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi575584.HMPREF0010_02782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108WHA. Bacteria.
COG2885. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ6RYW5.

Family and domain databases

Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR027385. OMP_b-brl.
IPR006664. OMP_bac.
IPR006665. OmpA-like.
[Graphical view]
PfamiPF13505. OMP_b-brl. 1 hit.
PF00691. OmpA. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS51123. OMPA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells."
    Choi C.H., Lee E.Y., Lee Y.C., Park T.I., Kim H.J., Hyun S.H., Kim S.A., Lee S.K., Lee J.C.
    Cell. Microbiol. 7:1127-1138(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN APOPTOSIS.
    Strain: ATCC 19606 / NCTC 12156 / CIP 70.34.
  2. "Purification and characterization of a major 40 kDa outer membrane protein of Acinetobacter baumannii."
    Jyothisri K., Deepak V., Rajeswari M.R.
    FEBS Lett. 443:57-60(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, FUNCTION AS A PORIN.
    Strain: ATCC 19606 / NCTC 12156 / CIP 70.34.

Entry informationi

Entry nameiOMP38_ACIBA
AccessioniPrimary (citable) accession number: Q6RYW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Live A.baumannii and purified Omp38 elicit identical effect with respect to the induction of apoptosis in epithelial cells. The Omp38-deficient mutant is not as able to induce apoptosis as the wild-type.

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.