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Protein

Outer membrane protein Omp38

Gene

omp38

Organism
Acinetobacter baumannii
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Porin. Induces apoptosis in human laryngeal epithelial HEp-2 cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor).2 Publications

Miscellaneous

Live A.baumannii and purified Omp38 elicit identical effect with respect to the induction of apoptosis in epithelial cells. The Omp38-deficient mutant is not as able to induce apoptosis as the wild-type.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processApoptosis, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein Omp38
Alternative name(s):
Outer membrane protein OmpA
Outer membrane protein OmpAb
Gene namesi
Name:omp38
Synonyms:ompA
OrganismiAcinetobacter baumannii
Taxonomic identifieri470 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000029020820 – 356Outer membrane protein Omp38Add BLAST337

Interactioni

Subunit structurei

Homotrimer. Forms a pore with a size of 1.3 nm.1 Publication

Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi221 – 233Combined sources13
Helixi243 – 245Combined sources3
Helixi246 – 258Combined sources13
Beta strandi263 – 268Combined sources6
Helixi276 – 297Combined sources22
Helixi302 – 304Combined sources3
Beta strandi305 – 309Combined sources5
Helixi322 – 328Combined sources7
Beta strandi329 – 339Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TD3X-ray1.59A/B/C/D/E/F/G/H221-339[»]
3TD4X-ray1.79A/B/C/D/E/F/G/H221-339[»]
3TD5X-ray2.00A/B/C/D/E/F/G/H221-339[»]
4G4YX-ray1.70A/B/C/D/E/F/G/H221-339[»]
4G4ZX-ray1.80A/B/C/D/E/F/G/H221-339[»]
4G88X-ray1.70A/B/C/D/E/F/G/H221-339[»]
ProteinModelPortaliQ6RYW5
SMRiQ6RYW5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6RYW5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini221 – 339OmpA-likePROSITE-ProRule annotationAdd BLAST119

Sequence similaritiesi

Belongs to the OmpA family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108WHA Bacteria
COG2885 LUCA

Family and domain databases

CDDicd07185 OmpA_C-like, 1 hit
Gene3Di3.30.1330.60, 1 hit
InterProiView protein in InterPro
IPR011250 OMP/PagP_b-brl
IPR027385 OMP_b-brl
IPR006664 OMP_bac
IPR006665 OmpA-like
IPR036737 OmpA-like_sf
PfamiView protein in Pfam
PF13505 OMP_b-brl, 1 hit
PF00691 OmpA, 1 hit
PRINTSiPR01021 OMPADOMAIN
SUPFAMiSSF103088 SSF103088, 1 hit
SSF56925 SSF56925, 1 hit
PROSITEiView protein in PROSITE
PS51123 OMPA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RYW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSRIALAT MLVAAPLAAA NAGVTVTPLL LGYTFQDSQH NNGGKDGNLT
60 70 80 90 100
NGPELQDDLF VGAALGIELT PWLGFEAEYN QVKGDVDGAS AGAEYKQKQI
110 120 130 140 150
NGNFYVTSDL ITKNYDSKIK PYVLLGAGHY KYDFDGVNRG TRGTSEEGTL
160 170 180 190 200
GNAGVGAFWR LNDALSLRTE ARATYNADEE FWNYTALAGL NVVLGGHLKP
210 220 230 240 250
AAPVVEVAPV EPTPVAPQPQ ELTEDLNMEL RVFFDTNKSN IKDQYKPEIA
260 270 280 290 300
KVAEKLSEYP NATARIEGHT DNTGPRKLNE RLSLARANSV KSALVNEYNV
310 320 330 340 350
DASRLSTQGF AWDQPIADNK TKEGRAMNRR VFATITGSRT VVVQPGQEAA

APAAAQ
Length:356
Mass (Da):38,420
Last modified:July 5, 2004 - v1
Checksum:iF6E424870C93C42F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY485227 Genomic DNA Translation: AAR83911.1
RefSeqiWP_000777878.1, NZ_PUDN01000002.1

Similar proteinsi

Entry informationi

Entry nameiOMP38_ACIBA
AccessioniPrimary (citable) accession number: Q6RYW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

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