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Protein

Fructose-1,6-bisphosphatase

Gene

fbp

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Magnesium 1By similarity
Metal bindingi94 – 941Magnesium 1By similarity
Metal bindingi94 – 941Magnesium 2By similarity
Metal bindingi115 – 1151Magnesium 2By similarity
Metal bindingi115 – 1151Magnesium 3By similarity
Metal bindingi117 – 1171Magnesium 2; via carbonyl oxygenBy similarity
Metal bindingi118 – 1181Magnesium 3By similarity
Binding sitei210 – 2101SubstrateBy similarity
Binding sitei242 – 2421SubstrateBy similarity
Binding sitei262 – 2621SubstrateBy similarity
Binding sitei272 – 2721SubstrateBy similarity
Metal bindingi278 – 2781Magnesium 3By similarity

GO - Molecular functioni

  • fructose 1,6-bisphosphate 1-phosphatase activity Source: dictyBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • fructose metabolic process Source: dictyBase
  • gluconeogenesis Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-DDI-70263. Gluconeogenesis.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase (EC:3.1.3.11)
Short name:
FBPase
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase
Gene namesi
Name:fbp
ORF Names:DDB_G0270836
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270836. fbp.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Fructose-1,6-bisphosphatasePRO_0000312529Add
BLAST

Proteomic databases

PaxDbiQ6RYT0.

Interactioni

Subunit structurei

Homotetramer.Curated

Protein-protein interaction databases

STRINGi44689.DDB0216231.

Structurei

3D structure databases

ProteinModelPortaliQ6RYT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni118 – 1214Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the FBPase class 1 family.Curated

Phylogenomic databases

eggNOGiKOG1458. Eukaryota.
COG0158. LUCA.
InParanoidiQ6RYT0.
KOiK03841.
OMAiEANPMSW.
PhylomeDBiQ6RYT0.

Family and domain databases

HAMAPiMF_01855. FBPase_class1.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6RYT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNNLITLH RWLLSDTHKN MENKLEMANL FSGIALACKI TNNAIKRAGF
60 70 80 90 100
ESNFGLAGIT NVHSEDVKKL DVIANDAFKM ALKSTREVFC MVSEEEDSII
110 120 130 140 150
PVSQSQAGKY VVAFDPLDGS SNLDCNVSVG SIFSIWPKAS KDHNYSNDDV
160 170 180 190 200
LRKGRDMTAA GYALYGSATM LVLTFGQGVY GFTLDNHIGE FVLTHVEMRI
210 220 230 240 250
RTKGSIYSIN EGNSVFWDKA TQEYVKAIKS GADGRAPYSS RYIGSMVSDI
260 270 280 290 300
HRTLLYGGIF MYPGDTKSPN GKLRYLYEVA PLSFIMEQAA GKSTNGSSPC
310 320 330 340
LDMIPKSIHE RVPVFMGSPA CIDELLAFQK KFNHNHSTTS QHEKDN
Length:346
Mass (Da):38,204
Last modified:July 5, 2004 - v1
Checksum:i2F1A15EEAC62DE39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY485279 Genomic DNA. Translation: AAS48589.1.
AAFI02000005 Genomic DNA. Translation: EAL72768.1.
RefSeqiXP_646323.1. XM_641231.1.

Genome annotation databases

EnsemblProtistsiDDB0216231; DDB0216231; DDB_G0270836.
GeneIDi8617278.
KEGGiddi:DDB_G0270836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY485279 Genomic DNA. Translation: AAS48589.1.
AAFI02000005 Genomic DNA. Translation: EAL72768.1.
RefSeqiXP_646323.1. XM_641231.1.

3D structure databases

ProteinModelPortaliQ6RYT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0216231.

Proteomic databases

PaxDbiQ6RYT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0216231; DDB0216231; DDB_G0270836.
GeneIDi8617278.
KEGGiddi:DDB_G0270836.

Organism-specific databases

dictyBaseiDDB_G0270836. fbp.

Phylogenomic databases

eggNOGiKOG1458. Eukaryota.
COG0158. LUCA.
InParanoidiQ6RYT0.
KOiK03841.
OMAiEANPMSW.
PhylomeDBiQ6RYT0.

Enzyme and pathway databases

UniPathwayiUPA00138.
ReactomeiR-DDI-70263. Gluconeogenesis.

Miscellaneous databases

PROiQ6RYT0.

Family and domain databases

HAMAPiMF_01855. FBPase_class1.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A first glimpse into the pattern and scale of gene transfer in Apicomplexa."
    Huang J., Mullapudi N., Sicheritz-Ponten T., Kissinger J.C.
    Int. J. Parasitol. 34:265-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiF16P_DICDI
AccessioniPrimary (citable) accession number: Q6RYT0
Secondary accession number(s): Q55D08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.