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Protein

Fructose-1,6-bisphosphatase

Gene

fbp

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Magnesium 1By similarity1
Metal bindingi94Magnesium 1By similarity1
Metal bindingi94Magnesium 2By similarity1
Metal bindingi115Magnesium 2By similarity1
Metal bindingi115Magnesium 3By similarity1
Metal bindingi117Magnesium 2; via carbonyl oxygenBy similarity1
Metal bindingi118Magnesium 3By similarity1
Binding sitei210SubstrateBy similarity1
Binding sitei242SubstrateBy similarity1
Binding sitei262SubstrateBy similarity1
Binding sitei272SubstrateBy similarity1
Metal bindingi278Magnesium 3By similarity1

GO - Molecular functioni

  • fructose 1,6-bisphosphate 1-phosphatase activity Source: dictyBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • fructose 1,6-bisphosphate metabolic process Source: GO_Central
  • fructose 6-phosphate metabolic process Source: GO_Central
  • fructose metabolic process Source: dictyBase
  • gluconeogenesis Source: dictyBase
  • sucrose biosynthetic process Source: GO_Central

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-DDI-70263 Gluconeogenesis
UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase (EC:3.1.3.11)
Short name:
FBPase
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase
Gene namesi
Name:fbp
ORF Names:DDB_G0270836
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270836 fbp

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: dictyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003125291 – 346Fructose-1,6-bisphosphataseAdd BLAST346

Proteomic databases

PaxDbiQ6RYT0
PRIDEiQ6RYT0

Interactioni

Subunit structurei

Homotetramer.Curated

Protein-protein interaction databases

STRINGi44689.DDB0216231

Structurei

3D structure databases

ProteinModelPortaliQ6RYT0
SMRiQ6RYT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni118 – 121Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the FBPase class 1 family.Curated

Phylogenomic databases

eggNOGiKOG1458 Eukaryota
COG0158 LUCA
InParanoidiQ6RYT0
KOiK03841
OMAiQSGLVCR
PhylomeDBiQ6RYT0

Family and domain databases

CDDicd00354 FBPase, 1 hit
HAMAPiMF_01855 FBPase_class1, 1 hit
InterProiView protein in InterPro
IPR000146 FBPase_class-1
IPR033391 FBPase_N
IPR028343 FBPtase
IPR020548 Fructose_bisphosphatase_AS
PANTHERiPTHR11556 PTHR11556, 1 hit
PfamiView protein in Pfam
PF00316 FBPase, 1 hit
PIRSFiPIRSF500210 FBPtase, 1 hit
PIRSF000904 FBPtase_SBPase, 1 hit
PRINTSiPR00115 F16BPHPHTASE
PROSITEiView protein in PROSITE
PS00124 FBPASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6RYT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNNLITLH RWLLSDTHKN MENKLEMANL FSGIALACKI TNNAIKRAGF
60 70 80 90 100
ESNFGLAGIT NVHSEDVKKL DVIANDAFKM ALKSTREVFC MVSEEEDSII
110 120 130 140 150
PVSQSQAGKY VVAFDPLDGS SNLDCNVSVG SIFSIWPKAS KDHNYSNDDV
160 170 180 190 200
LRKGRDMTAA GYALYGSATM LVLTFGQGVY GFTLDNHIGE FVLTHVEMRI
210 220 230 240 250
RTKGSIYSIN EGNSVFWDKA TQEYVKAIKS GADGRAPYSS RYIGSMVSDI
260 270 280 290 300
HRTLLYGGIF MYPGDTKSPN GKLRYLYEVA PLSFIMEQAA GKSTNGSSPC
310 320 330 340
LDMIPKSIHE RVPVFMGSPA CIDELLAFQK KFNHNHSTTS QHEKDN
Length:346
Mass (Da):38,204
Last modified:July 5, 2004 - v1
Checksum:i2F1A15EEAC62DE39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY485279 Genomic DNA Translation: AAS48589.1
AAFI02000005 Genomic DNA Translation: EAL72768.1
RefSeqiXP_646323.1, XM_641231.1

Genome annotation databases

EnsemblProtistsiEAL72768; EAL72768; DDB_G0270836
GeneIDi8617278
KEGGiddi:DDB_G0270836

Similar proteinsi

Entry informationi

Entry nameiF16P_DICDI
AccessioniPrimary (citable) accession number: Q6RYT0
Secondary accession number(s): Q55D08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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